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All Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran
Ni Nyoman Ayu Dewi
Departemen Biokimia, Fakultas Kedokteran, Universitas Udayana
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Potensi FuMA stem cells, kombinasi fukoidan dan Bone Marrow Stem Cells (BMSCs), sebagai penatalaksanaan mutakhir pada Infark Miokard Akut Agung Bagus Sista Satyarsa; Sang Ayu Arta Suryantari; Putu Gupta Arya Gumilang; Ni Nyoman Ayu Dewi
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (648.161 KB) | DOI: 10.15562/ism.v10i1.300

Abstract

Introduction: Acute myocardial infarction (AMI) is the leading cause of death worldwide. One of the causes of high morbidity and mortality is progressive and irreversible nature of the disease and current treatments are still not optimal in resolving these problems. Thus, this paper aims to describe the potential effect of combination of fucoidan and bone marrow stem cells (namely FuMA stem cells) as the novel management of AMI.Method: The method used in our paper was literature searching by including the keywords of AMI, BMSCs, and fucoidan.Result: Fucoidan from brown seaweed has shown a great potential effect as anti-inflammatory, anti-coagulant, anti-atherogenic, anti-oxidant, and anti-fibrotic. It limits the infarct area and increases SDF-1, CXCR4 and Akt expression as well as LVEF. However, fucoidan has not been able to regenerate cardiomyocyte cells in AMI. It takes a combination of BMSCs that have been shown to prevent the expansion of infarction area and improve post-infarction function.Conclusion: Thus, FuMA stem cells hold a great potential novel therapy for AMI. Further studies are needed to unveil the potential of FuMA stem cells in AMI management.
Hubungan konsumsi kopi hitam terhadap tekanan darah pada perokok dewasa Ni Made Sarah Manacika Naraswari; I Wayan Gde Sutadarma; Ni Nyoman Ayu Dewi
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.356 KB) | DOI: 10.15562/ism.v%vi%i.700

Abstract

Background: Unhealthy lifestyles such as smoking and consuming coffee can affect blood pressure.Aim: The study aims to evaluate the association between black coffee consumption and hypertension.Method: This study design was cross-sectional with 93 participants. Data taken from questionnaire measurements and blood pressure measurements at a time.Results and conclusion: The results showed 79.6% had abnormal blood pressure and 20.4% had normal blood pressure. In this study male smoker workers who consumed black coffee were statistically related to blood pressure (p <0.05). Pola hidup yang tidak sehat seperti merokok dan mengkonsumsi kopi dapat mempengaruhi tekanan idarah.Tujuan: Untuk mengevaluasi hubungan konsumsi kopi hitam dan tekanan darah.Metode: Desain penelitian ini cross-sectional dengan 93 peserta sampel. Data yang diambil berasal dari pengukuran kuisioner dan pengukuran tekanan darah sewaktu.Hasil dan simpulan: Terdapat 79,6% sampel memiliki tekanan idarah tidak normal dan 20,4% memiliki tekanan darah normal. Dalam penelitian ini pekerja laki-laki perokok yang mengkonsumsi kopi hitam berhubungan secara statistik dengan tekanani darah (p < 0,05). 
Co-Authors Agung Bagus S. Satyarsa I Wayan Gde Sutadarma Ni Made Sarah Manacika Naraswari Putu Gupta Arya Gumilang Sang Ayu Arta Suryantari