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Yusnita Mirna Anggraeni
Badan Riset dan Inovasi Nasional, Indonesia
Health Professions Public Health

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Journal : Jurnal Kesehatan

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Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit Sri Wahyuni Handayani; Dwi Susilo; Arum Triyas Wardani; Yusnita Mirna Anggraeni
Jurnal Kesehatan Vol 13, No 3 (2022): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i3.3229

Abstract

Tobacco (Nicotiana tabacum) is a plant that can be used as a natural insecticide. Tobacco extracts can be made as alternative nanoinsecticides to be used as Aedes aegypti control. This study aims to obtain information on the toxicity of tobacco nanoinsecticides and obtain the LD50 of tobacco nanoinsecticides in mice. The research was conducted at the Center for Disease Vector and Reservoir Research and Development (B2P2VRP) with a pure experimental method. The results showed that the particle size ranged from 26.9; 53.7 and 89nm. The results of the metal content test with an Atomic Absorption Spectrophotometer (AAS) showed the presence of Ag content in the nanoinsecticide solution made. Spectrophotometry measurements showed a peak at a wavelength of 420 nm and functional group bonds were formed. The characteristic SEM photo shows the particle morphology in the form of round-face crystals. The results of the toxicity test using the OECD 423 LD50 method at 2500mg/kg BB showed that tobacco nanoinsecticides were in the slightly toxic category. Administration of tobacco nanoinsecticides causes toxic symptoms in the form of decreased cardiac activity, convulsions, and decreased movement activity, while from the histopathological test results, the number of kidney injuries is in the range of 10 to 25%.
Co-Authors Arum Triyas Wardani Dwi Susilo Sri Wahyuni Handayani