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TOTAL CHOLESTEROL AND C-REACTIVE PROTEIN LEVELS AS A PROGNOSTIC MARKERS OF UROSEPSIS wahyudi, septa surya; Hardjowijoto, Sunaryo; Soebadi, Doddy M; Soetojo, Soetojo; Djojodimedjo, Tarmono; Budiono, Budiono
Indonesian Journal of Urology Vol 23 No 1 (2016)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v23i1.198

Objective: To investigate whether total cholesterol and C-reactive protein levels could be use as a prognostic factor for outcome in patients with urosepsis. Material & Methods: An analytic observational study using 30 patients assigned for total cholesterol and CRP level at the day of admission, three days later, and on the last day of sepsis or on the dead day. All subjects were managed according to standard urosepsis therapy. At the 14th day of treatment, patients were evaluated with a clinical severity score. Then we classified the outcome as improve/good condition, worse, and died. The variables were statistically tested using Spearman’s rho test with software SPSS 20. P < 0.05 was consider significant. Result: From 30 subjects with urosepsis, we found 15 patients in septic condition, 14 patients had severe sepsis and one patient had septic shock. The mean of total cholesterol level in patient with died and worse was lower than that in patient with good outcome. Day-1 (63.25 mg/dl and 101.38 mg/dl vs 119.5 mg/dl), day-3 (56.0 mg/dl and 93.6 mg/dl vs 128.6 mg/dl) and last day/died day (51.0 mg/dl and 82.25 mg/dl vs 154.8 mg/dl). The mean of CRP level in patient with died and worse was higher than that in patient with good outcome. Day-1 (177.18 mg/l and 146.74 mg/l vs 88.1 mg/l), day 3 (127.1 mg/l and 148.8 mg/l vs 56.2 mg/l) and last day/died day (141.88 mg/l and 88.71 mg/l vs 31.58 mg/l). These were statistically significant between total cholesterol and CRP levels in determining the outcome of urosepsis patient. Day-1 (p 0.000 vs 0.011), day-3 (p 0.000 vs 0.002), and last day/died day (p 0.000 vs 0.000). The coefficient correlation total cholesterol was better than CRP in day-1 (rho -0.633 vs 0.459), day-3 (rho -0.755 vs 0.543), and last day/died day (rho -0.874 vs 0.686). Conclusion: Low total cholesterol and high C-reactive protein levels can be used as poor prognostic in urosepsis patients. Total cholesterol level was better than CRP as a prognostic marker.

THE RELATION OF HYPOSPADIAS TYPES, AGES, AND SURGICAL TECHNIQUES FOR URETHROCUTANEOUS FISTULA COMPLICATION IN CHILD HYPOSPADIAS CASES Widjajana, Desy Pratiwi; Wahyudi, Septa Surya; Sutejo, Ika Rahmwati
Indonesian Journal of Urology Vol 26 No 2 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i2.451

Objective: To find correlation between hypospadias type, age, and surgical technique for urethrocutaneous fistula in child hypospadias cases. Material & Method: This research was an observational analytic research with cross sectional approach. It was conducted at Bina Sehat Jember Hospital, Paru Jember Hospital, and Bhayangkara Bondowoso Hospital. The research samples were hypospadias patients who had done hypospadias repair with susceptible age from 0 months until 16 years. Result: In this study, was found correlation between type of hypospadias with urethrocutaneous fistula (p=0.03 and r=0.43). And the other hand, this research did not find relationship between age at hypospadias surgery with urethrocutaneous fistula complication (p=0.34 and r=0.3). The results of this study indicate that the incidence of urethrocutanoeus fistula complications in the surgery using TIP technique was greater than Onlay Island Flap technique, but in this study, there was no association between hypospadias surgery technique used with complications of uretrocutanoeus fistula (p=0.3 and r=0.22). Conclusion: In this study, there was a significant relationship between hypospadias type with urethrocutaneous fistula complication with statistically moderate strength and positive correlation direction. This study did not show any significant relationship between age and hypospadias surgery technique with complications of urethrocutanoeous fistula.

ANALYSIS OF DIFFERENCES DEGREE OF SEVERITY AND QUALITY OF LIFE OF BPH DIABETES WITH BPH NON-DIABETES PATIENTS Kurnia Putra, Prayoga Triyadi; Wahyudi, Septa Surya; Novi M, Ancah Caesarina
Indonesian Journal of Urology Vol 26 No 2 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i2.446

Objective: Benign Prostatic Hyperplasia (BPH) is a benign tumor located in prostate caused by prostate cell that will continuously grows which covalent with the aging process and the dihidrotestosteron level (DHT) increase. Prostate Hyperplasia can stop the urethra pars prostatics and causesa clogging in the urine’s flow excretes from bladder. Lower Urinary Tract Symptomps (LUTS) is a bladder muscle compensation mechanism to excrete urine. Diabetes Mellitus (DM) is one of the risk factors of BPH. This research aimed to find the differences on the degree of severity and quality of life BPH DM with BPH non-DM. Material & Methods: This research was observational analytic with cross sectional design which done to 32 subjects that consist of 16 BPH-DM subjects and 16 BPH non-DM in Bina Sehat Hospital Jember, Paru Hospital Jember, and Bhayangkara Hospital Bondowoso which meet to the inclusion and exclusion criteria. Data acquired from lead interview result using International Prostate Symptoms Score (IPSS) questionnaire to evaluate the degree of severity and World Health Organization Quality of Life (WHOQOL-BREF) questionnaire to evaluate the quality of life. The data processing using Mann Whitney’s comparative test. Results: IPSS and physic domain, psychology and social had p value in a row 0.001; 0.000; 0.001; and 0.001. Conclusion: It showed that there was a meaningful difference between BPH DM with BPH non-DM. Environment domain had p value of 0.373. It showed the non-meaningful difference between BPH DM with BPH non-DM.

Perbedaan Efek Paparan Pestisida Kimia dan Organik terhadap Kadar Glutation (GSH) Plasma pada Petani Padi Insani, Ain Yuanita; Novi Marchianti, Ancah Caesarina; Wahyudi, Septa Surya
Jurnal Kesehatan Lingkungan Indonesia Vol 17, No 2 (2018): Oktober 2018
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.17.2.63-67

Latar belakang:Serangan hama dan penyakit tanaman semakin meluas, sehingga para petani tidak dapat menghindari penggunaan pestisida kimia. Pestisida kimia bersifat polutan dan mengakibatkan terbentuknya radikal bebas yang dapat menyebabkan kerusakan organ. WHO memperkirakan ada 1,5 juta kasus keracunan pestisida terjadi pada pekerja di sektor pertanian. Tubuh membutuhkan antioksidan untuk menanggulangi radikal bebas akibat pestisida kimia. Salah satu antioksidan yang sering diukur untuk melihat dampak peningkatan radikal bebas adalah glutation(GSH). Penelitian ini bertujuan untuk mengetahui perbedaan efek paparan pestisida kimia dan organik terhadap kadar GSH plasma pada petani padi.Â Metode:Jenis penelitian yang digunakan adalah analitik observasional dengan rancangan penelitiancross sectional. Penelitian ini menggunakan sampel 30 orang, 15 orang petani organik di Desa Lombok Kulon Kecamatan Wonosari Kabupaten Bondowoso dan 15 orang petani anorganik di Desa Dawuhan Kecamatan Tenggarang Kabupaten Bondowoso.Â Pengambilan sampel darah dilakukan di vena mediana cubiti, selanjutnya dilakukan pengukuran kadar GSH plasma menggunakan metode Elman. Uji statistika dilakukan dengan menggunakan uji Unpaired T-test.Hasil:Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara kadar GSH plasma petani anorganik dan organik p<0.05. Petani anorganik memiliki rata-rata kadar GSH plasma lebih rendah dibandingkan dengan rata-rata kadar GSH plasma petani organik. Hal tersebut terjadi karena para petani anorganik mendapatkan paparan polutan berlebih dari zat-zat kimia dalam pestisida kimia sedangkan petani organik menggunakan bahan alami sehingga tidak menimbulkan residu dalam tubuh.Simpulan: Terdapat perbedaan yang signifikan antara kadar GSH plasma pada kelompok petani anorganik dan kelompok petani organik. Kadar GSH plasma petani anorganik lebih rendah dibandingkan dengan kadar GSH plasma petani organik.Â ABSTRACTTitle: The Difference Effect of Chemical and Organic Pesticides Exposure to Plasma Glutathione (GSH) on Rice FarmersBackground:Â Pests and plant diseases are widespread in agriculture so the use of chemical pesticides can not avoid. Pesticides are pollutants which forming free radicals and cause organ damage. WHO estimates that 1.5 million cases of pesticide poisoning occur in agricultural workers. The body needs antioxidant to cope free radicals due to chemical pesticides. GSH is one of antioxidants often measured to see the effects of increased free radicals in the body.This study aims to determine the differences effect of chemical and organic pesticide exposure on plasma glutathione (GSH) levels in rice farmers.Methods:Â The type of this research is observational analytics with cross sectional design. This study used 30 people as sample, 15 people organic farmers in the Desa Lombok Kulon, Kecamatan Wonosari, Bondowoso and 15 people inorganic farmers in Desa Dawuhan, Kecamatan Tenggarang, Bondowoso. Blood sampling was done in mediana cubiti vein, then measured ofÂ plasma GSH using Elman method. The statistical test was done by using Unpaired T-test.Results:Â The resulf of this research showed that there is a significant difference between plasma GSH level of inorganic farmer and organic farmer p <0.05. The average plasma GSH level of inorganic farmersare lower than average plasma GSH levels of organic farmers. This result is caused by excessive pollutants of chemicals contained in the pesticide exposed inorganic farmers while the group of organic farmers used natural ingredients in the pesticide so it did not makes residues in the body of farmers.Conclusion:Â Based on this, it is advisable for farmers to be more wise to use chemical pesticides in accordance with established rules and better recommended to replace the use of chemical pesticides with organic pesticides.

DIFFERENCES IN THE EFFECTIVENESS OF SELECTIVE ALPHA BLOCKER THERAPY COMBINED WITH 5-ALPHA REDUCTASE INHIBITOR ON IPSS VALUE OF BPH LUTS PATIENTS Wahyudi, Septa Surya; Probosutiksna, Nuno Febrian; Suswati, Enny
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.615

Objective: The purpose of this study is to know the differences in effectiveness between SAB administration with combination 5-ARI administration assessed by IPSS evaluation in BPH LUTS patients. Material & Methods: This observational analytic with a cross-sectional design study had been done to 50 BPH LUTS patients that obtained at Paru Jember, Bina Sehat Jember, and Bhayangkara Bondowoso Hospital. These samples had got by simple random sampling method and include in inclusion with exclusion criteria freely. Results: This comparison study between the type of medical therapy administration and total IPSS decrease, IPSS-voiding decrease, IPSS-storage decrease, IPSS-QoL, and prostate volume give significancies as follows: p=0.002; p<0.001; p<0.001; p<0.05; p<0.001. Conclusion: There are significant differences between the type of medical therapy (SAB or 5-ARI combination) and total IPSS decrease, IPSS-voiding decrease, IPSS-storage decrease, IPSS-QoL, and prostate volume.

DIFFERENCES IN THE EFFECTIVENESS OF SELECTIVE ALPHA BLOCKER THERAPY COMBINED WITH 5-ALPHA REDUCTASE INHIBITOR ON IPSS VALUE OF BPH LUTS PATIENTS Wahyudi, Septa Surya; Probosutiksna, Nuno Febrian; Suswati, Enny
Indonesian Journal of Urology Vol 27 No 2 (2020)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v27i2.615

Objective: The purpose of this study is to know the differences in effectiveness between SAB administration with combination 5-ARI administration assessed by IPSS evaluation in BPH LUTS patients. Material & Methods: This observational analytic with a cross-sectional design study had been done to 50 BPH LUTS patients that obtained at Paru Jember, Bina Sehat Jember, and Bhayangkara Bondowoso Hospital. These samples had got by simple random sampling method and include in inclusion with exclusion criteria freely. Results: This comparison study between the type of medical therapy administration and total IPSS decrease, IPSS-voiding decrease, IPSS-storage decrease, IPSS-QoL, and prostate volume give significancies as follows: p=0.002; p<0.001; p<0.001; p<0.05; p<0.001. Conclusion: There are significant differences between the type of medical therapy (SAB or 5-ARI combination) and total IPSS decrease, IPSS-voiding decrease, IPSS-storage decrease, IPSS-QoL, and prostate volume.

Hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun Septa surya wahyudi; Ayu munawaroh aziz; Alfina kamelia fakhriyah
Majalah Kedokteran Andalas Vol 44, No 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i2.p93-103.2021

Kualitas tidur yang baik harus dicapai seseorang untuk mendapatkan manfaat dari tidur. Selama periode tidur, tubuh menyekresikan GH dalam darah. Sekresi GH mencapai puncaknya saat tidur nyenyak terutama tengah malam. Kadar GH yang disekresikan saat tidur dapat berpengaruh terhadap pertumbuhan fisik terutama tinggi badan pada masa pertumbuhan.Penelitian ini merupakan observasional analitik, menggunakan pendekatan cross sectional. Bertujuan untuk mengetahui hubungan kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Teknik pengambilan sampel menggunakan teknik proportional stratified random sampling dengan menggunakan kriteria inklusi dan eksklusi. Teknik pengambilan data dilakukan dengan cara wawancara, pemeriksaan tinggi badan berat badan. Analisis data dilakukan menggunakan uji Chi Square.Penelitian menunjukkan sampel yang mempunyai kualitas tidur baik yakni 26 sampel (86,7%), kualitas tidur buruk sebanyak 4 sampel (13,3%). Sebanyak 16 sampel (53,3%) mempunyai tinggi badan sesuai nilai normal menurut usia dalam pedoman WHO, Kemenkes RI, dan CDC pada tahun 2001, 14 sampel (46,7%) lainnya tidak sesuai pedoman tersebut. Hasil uji Chi Square menunjukkan hubungan yang signifikan antara kualitas tidur dengan tinggi badan (p=0,022). Hal ini menunjukkan bahwa terdapat hubungan antara kualitas tidur dengan tinggi badan pada remaja usia 10-15 tahun. Semakin baik kualitas tidur, maka tinggi badan anak akan semakin sesuai dengan nilai normal menurut usia.

MODULASI AKTIVITAS CIPROFLOXACIN TERHADAP Pseudomonas aeruginosa OLEH N-ASETILSISTEIN DAN VITAMIN C Agustina, Dini; Indreswari, Laksmi; Tristianti, Farmitalia Nisa; El Milla, Kardiana Izza; Hermansyah, Bagus; Wahyudi, Septa Surya; Firdaus, Jauhar
Syifa'Medika Vol 11, No 1 (2020): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v11i1.2389

Pseudomonas aeruginosa merupakan salah satu bakteri penyebab infeksi yang sulit diobati dengan terapi obat tunggal karena tingkat keberhasilan yang rendah serta kecenderungan menjadi resisten selama pemberian obat tunggal. Salah satu antibiotik yang digunakan adalah ciprofloxacin. Untuk meningkatkan sensitivitas P. aeruginosa terhadap ciprofloxacin, kombinasi N-asetilsistein atau vitamin C mungkin diperlukan. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi antara N- asetilsistein dan ciprofloxacin serta antara vitamin C dan ciprofloxacin terhadap pertumbuhan P. aeruginosa. Penelitian ini menggunakan uji difusi cakram yang berisi kombinasi konsentrasi ciprofloxacin konstan 1mg/ml dengan N-asetilsistein dalam berbagai konsentrasi 1,25mg/ml, 2,5mg/ml, 5mg/ml, 10mg/ml, dan 20mg/ml dan vitamin C dengan 2,5 mg/ml; 5 mg/ml; 10 mg/ml; 20 mg/ml; dan konsentrasi 40 mg/ml. Dalam kombinasi antara N-asetilsistein dan ciprofloxacin, peningkatan sensitivitas P. aeruginosa terjadi pada konsentrasi 10ml/mg pada kombinasi obat, dan dalam kombinasi antara vitamin C dan ciprofloxacin, peningkatan sensitivitas P. aeruginosa terjadi pada konsentrasi 2, 5 ml/mg pada kombinasi obat di atas kontrol positif. Regresi logaritmik mengungkapkan konsentrasi minimal N- asetilsistein dan vitamin C masing-masing adalah 9,593 mg/ml dan 1,9 mg/ml dapat meningkatkan sensitivitas P. aeruginosa pada ciprofloxacin. Dapat disimpulkan bahwa N-asetilsistein dan vitamin C meningkatkan aktivitas ciprofloxacin untuk menghambat pertumbuhan P. aeruginosa in vitro.

HYPERTENSION EFFECTS ON THE DECREASED KIDNEY FUNCTION PROGRESIVITY IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Dhiemas Trisyuananda Eniestama; Aziz, Ayu Munawaroh; Wahyudi, Septa Surya
Indonesian Journal of Urology Vol 28 No 1 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i1.660

Objective: A comprehensive knowledge about BPH and hypertension is needed to reduce morbidity and mortality in patients with decreased kidney function due to the two diseases. Material & Methods: This research used the observational analytics method with cross-sectional design. This research used secondary data from medical records of BPH patients in Bina Sehat Hospital and Paru Hospital from January 1st to December 1st 2019. Results: Comparative serum creatinine test results in hypertensive BPH patients with non-hypertensive BPH patients using the Mann Whitney test, obtained p= 0.000. Based on these results it can be concluded that there are significant differences in serum creatinine between hypertensive BPH patients and non-hypertensive BPH patients. Correlation test results using the Spearman test between serum creatinine with blood pressure systole and diastole all samples obtained each p= 0.000 r= 0.399 for systolic blood pressure and p= 0.000 r= 0.337 for diastole blood pressure. Based on these results it can be concluded that there is a significant correlation between serum creatinine with systolic and diastolic blood pressure of the patient. Conclusion: Hypertension will worsen the kidney function decline in BPH patients seen from an increase in serum creatinine.

RELATION OF TOTAL CHOLESTEROL TO PROSTATE VOLUME AND INTRAVESICAL PROSTATIC PROTRUSION IN BENIGN PROSTATIC HYPERPLASIA PATIENTS Made Devi Desyana Arisandi; Wahyudi, Septa Surya; Fatmawati, Heni
Indonesian Journal of Urology Vol 28 No 2 (2021)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v28i2.675

Objective: To determine the relationship between total cholesterol, prostate volume, and intravesical prostatic protrusion in patients with benign prostatic hyperplasia. Material & Methods: This study used a cross-sectional method, carried out at the Paru and Bina Sehat Hospital in Jember. The sample in this study was BPH patients who met the inclusion criteria taken through medical record data from October 2019 to January 2020 Results: Samples on this study amounted to 33 patients. In this study, there was a difference between normal and high cholesterol with prostate volume in BPH patients (p = 0.00) and there was a significant relationship between cholesterol and prostate volume with strong correlation strength (p = 0.00 and r = 0.751) while the difference between high and normal cholesterol with IPP obtained insignificant results (p = 0.211) and the correlation between cholesterol and IPP obtained an insignificant relation with weak correlation strength (p = 0.217 and r = 0.221). Conclusion: There is a significant relationship between total cholesterol and prostate volume and a significant difference in prostate volume between normal and high total cholesterol in BPH patients, while there is no significant result between total cholesterol and intravesical prostatic protrusion in BPH patients.

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