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All Journal Indonesian Journal of Urology Indonesian Journal of Cancer
CHAIDIR A MOCHTAR, CHAIDIR A
Sub Bagian Urologi/Bagian Bedah, FK Universitas Indonesia/RSUPN Cipto Mangunkusumo, Jakarta
Health Professions Medicine & Pharmacology Public Health

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Terapi Radikal pada Penderita Kanker Prostat: Tindak Lanjut Jangka Panjang dan Faktor Prediksi Survival UMBAS, RAINY; MOCHTAR, CHAIDIR A; HAMID, RIZAL A
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Radical treatment in the form of radical prostatectomy (PR) or external beam radiotherapy (EBRT) considered as gold standard in the management of localized and in some selected cases of locally advanced prostate cancer patients. Aim of this study is to know the treatment results of RP and EBRT in prostate cancer patients with T1-3 at “Cipto Mangunkusumo” Hospital and “Dharmais” Cancer Hospital, Jakarta. Analysis to the prediction factors in those two treatment modalities was also done. There were 110 patients among 610 prostate cancer patients in those two hospitals between January 1995 and December 2007 who received radical treatment. Radical prostatectomy was done to 43 patients with median age of 63 years (range: 50-74 years), and the other 67 patients with median age of 70 years (range: 50-82 years) were treated by EBRT. Median survival was 101 months and 85 months for patients treated with RP and EBRT respectively while 5-year survival rate was 68.4% and 69.2% for those respective groups. There was no clinical parameter in the group of patients who underwent PR which significantly correlated with survival. In the EBRT group, low grade tumor was significantly correlated with better survival. In conclussion, less than 20% of prostate cancer patients in those two hospitals underwent radical treatment in form of PR or EBRT. Median survival for patients treated with PR was better than those who received EBRT. Tumor grade was the only survival predictor factor in the EBRT group.
Sistem Skoring Nefrometri R.E.N.A.L: Sistem Berstandar yang Komprehensif Dalam Menilai Ukuran, Lokasi, dan Kedalaman Tumor Ginjal REZA, MOCHAMMAD; RAKHMAN, ARIEF; MOCHTAR, CHAIDIR A
Indonesian Journal of Cancer Vol 8, No 2 (2014): April-Juni 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

The treatment of localized renal cell carcinoma remains subjective.The R.E.N.A.L.- Nephrometry Score quantifies the characteristics of renal mass anatomy based on radiologic findings to provide a standardized objective descriptive system in an reproducible manner. We evaluate the utility of this system in predicting tumor resectability, operative approach and risk of complication, and their relevance to clinical practice.Electronic literature research was performed to access the main series of literature in the past 4 years since the scoring system developed. The articles were then analyzed and selected to address these issues. Fifteen peer-reviewed publications (2009 to 2012) were selected. Most of the studies were analyzed using the prospective acquired database. Increasing tumor complexity was asscociated with greater overall nephrometry score in patient underwent renal neprectomy and partial neprectomy. Compared with patients who underwent partial nephrectomy, the patients treated with radical nephrectomy had a significantly greater size (R), central proximity (N), and location (L) component scores. There were more complications among patients with higher R.E.N.A.L scores who underwent partial nechrectomy (PN) thanin patients with PN who did not developcomplications. The R.E.N.A.L nephrometry scoring system has good interobserver reliability showed by the similar sum of nephrometry score concordance to the R, E, N, A, and L components among surgeons in different centre. The R.E.N.A.L nephrometry standardize the reporting of solid renal masses and appears to effectively stratify the treatment choice for patients. Nephrometry aids in objectifying previously subjective measure and provide more meaningful comparison of treatment recommendation or results in published series.
Karsinoma Pelvis Renis dan Ureter di Jakarta: Karakteristik dan Faktor Risiko ZULFIKAR, YEVRI; UMBAS, RAINY; MOCHTAR, CHAIDIR A
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

To study the characteristics,diagnosis and role of upper urinary tract stone as risk factors of renal pelvis and ureter malignancy. Data were collected from medical record of Urology Clinic Ciptomangunkusumo Hospital and Dharmais Cancer Hospital, Jakarta during the period between January 1995 and December 2009. The clinical factors which were studied are age, gender, symptoms, history of stone disease, imaging, histopathology , primary lesions of the tumor, and stage. There were 42 renal pelvis and ureter carcinoma patients during 15 years period. With mean age of 53.5 years (range 33 – 74). There were 54.8% cases associated with stone disease. The most common histopatology was Transitional Cell Carcinoma (TCC) (47.6%). Ninety two point nine percent cases with Squamous Cell Carcinoma (SCC) are associated with stone or history of operation for stone removal. Symptom of flank tumor occurred in 61.0 % patients, flank pain 58.5 %, and hematuria 53.7 %. Only 71.4 % of cases were detected pre operatively. Pre operative imaging detection were 89.3%, 53.8%, 20.7% for CT Scan USG and IVU respectively . Fifty two point five percents of patients were found on Stage IV and 47.8 % of these patients were associated with stone disease. Most of patients with renal pelvis and ureter carcinoma were associated with stone disease, especially in patients with SCC tumors. There are still some problems in detecting these tumors especially in early stage.
Internal Genital Organ-preserving Radical Cystectomy: A Case Report WIDIA, FINA; SITUMORANG, GERHARD R; HAMID, AGUS RIZAL A.H; MOCHTAR, CHAIDIR A
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTAdenocarcinoma of the bladder is usually managed by radical cystectomy. However, recent literature shows that internal genital organ-preserving radical cystectomy is feasible in selected cases in order to get a better impact on patient’s psychology, sexuality and potential fertility. Here, we report a 32-year-old woman with adenocarcinoma of the bladder who was managed with internal genital organ-preserving radical cystectomy. The patient was never had any child and the radiologic examination (MRI) showed no involvement of internal genitalia organ. This procedure aims to maintain fertility potential of the patient. Intraoperatively, no adhesion was found between the tumor and internal genitalia organ. The internal genitalia organ was successfully preserved during the radical cystectomy. ABSTRAKTata laksana adenokarsinoma kandung kemih umumnya berupa sistektomi radikal. Akan tetapi, penelitian terbaru menunjukkan bahwa preservasi organ internal genitalia dapat diterapkan pada kasus-kasus tertentu dengan tujuan untuk mempertahankan potensi seksual dan fertilitas pasien. Saat ini kami melaporkan seorang perempuan berusia 32 tahun dengan adenokarsinoma kandung kemih yang menjalani sistektomi radikal dengan tetap mempertahankan organ genitalia interna. Pasien merupakan nulipara dan pada pemeriksaan radiologi MRI tidak didapatkan infiltrasi tumor pada organ genitalia interna. Prosedur operasi dilakukan dengan tujuan mempertahankan potensi fertilitas. Intraoperatif, tidak didapatkan perlengketan antara tumor dan organ genitalia interna. Organ genitalia interna berhasil dipreservasi selama prosedur sistektomi radikal.
PENGARUH VOLUME BULI-BULI TERHADAP PANJANG PROSTAT PADA PEMERIKSAAN ULTRASONOGRAFI TRANSABDOMINAL Ali, Zulfikar; Mochtar, Chaidir A
Indonesian Journal of Urology Vol 16 No 1 (2009)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v16i1.357

Abstract

Objective: To study the effects of different bladder volumes on the length of prostatic protrusion as measured by transabdominal ultrasonography. Materials & Method: We did an observational study on 48 patients with BPH and urinary retention in Urology outpatient clinic of Cipto Mangunkusumo Hospital Jakarta from 1 March 2006 to 28 February 2007. The bladder of each patient was filled with 50 ml normal saline and increased stepwise by 50 ml each time until either an urge to void or a volume of 500 ml was reached. Length of prostatic protrusion was measured by transabdominal ultrasonography at each volume of bladder filling in every patient. Results: The average length of prostatic protrusion in 50, 100, 150, and 200 ml bladder filling was 11,14; 11,42; 11,88; 10,20 mm respectively. There is no statistically significant difference in the length of prostatic protrusion with transabdominal ultrasonography in each bladder volume. Conclusion: Prostatic protrusion length can be measured with bladder volumes between 50 ml to 200 ml and shows no significant difference.
EFEK KATETER TERHADAP FUNGSI PSA SERUM SEBAGAI PREDIKTOR VOLUME PROSTAT PADA PASIEN YANG TERBUKTI BENIGN PROSTATIC HYPERPLASIA PADA PEMERIKSAAN HISTOPATOLOGIS Tranggono, Untung; Mochtar, Chaidir A; Umbas, Rainy
Indonesian Journal of Urology Vol 16 No 1 (2009)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v16i1.359

Abstract

Objective: To define the use of Prostate Specific Antigen (PSA) as a predictor of prostate volume in catheterized BPH patients. Material & methods: Data were collected from medical record of symptomatic BPH patients who underwent prostate biopsy at Cipto Mangunkusumo Hospital Urology Clinic since 1994 until 2006. Data of age, serum PSA, indwelling catheter, maximal flow, urine residue, and prostate volume were recorded as variables. Patients who had histopathological result of BPH with or without prostatitis were included; while who had prostate carcinoma, high grade prostatic intraepithelial neoplasm (HGPIN), and BPH with atypical small acinar proliferation (ASAP) were excluded. Subject were then divided into 2 groups, catheterized or not. Data were analyzed using Mann-Whitney test, analysis of variance, correlation test and linear regression test. Results: Of  2283 patients were performed prostate biopsy, 1036 patients had results of BPH with or without prostatitis, 766 patients had prostate carcinoma, while 581 patient’s biopsy result were not recorded. Of the 1036 patients, 347 were catheterized, 192 non-catheterized, and 457 were not recorded. In the catheterized group the average age were 67,04 years old, serum PSA 26,88 ng/ml, prostate volume 54,33 ml, PSA density 0,39. In non-catheterized group the average age were 66,32 years old, serum PSA 16,58 ng/ml, prostate volume 53,94 ml, PSA density 0,33. Regression test showed that serum PSA could be used as a predictor of prostate volume (F=12,830; p < 0,001); in non-catheterized group it was stronger (F=12,989; p<0,001) than in catheterized group (F=6,814; p<0,01). The accuracy of serum PSA as a prostate volume predictor based on Receiver Operating Curve (ROC) as indicated by Area Under the Curve (AUC), in the catheterized group was 0,678 - 0,725 (p<0,001); in non-catheterized group was 0,723 - 0,784 (p<0,001). Conclusion: Serum PSA could be used as a predictor of prostate volume in patients with BPH wether catheterized or not. This predictor function is stronger in non-catheterized patients. Catheter has the effect of lowering the function of serum PSA as a prostate volume predictor in patients with BPH.
Co-Authors Adianti Khadijah, Adianti Agus Rizal A.H. Hamid, Agus Rizal A.H. Agus Rizal AH. Hamid, Agus Rizal AH. Ahmad Zulfan, Ahmad Andika Afriansyah, Andika Ari Astram, Ari ARIEF RAKHMAN, ARIEF Budi I Santoso, Budi I Firtantyo A Syahputra, Firtantyo A HAMID, AGUS RIZAL A.H Harrina E Rahardjo, Harrina E Junizaf Junizaf MOCHAMMAD REZA, MOCHAMMAD Noor Riza Perdana, Noor Riza Partini P Trihono, Partini P Prahara Yuri R. Danarto, R. Rainy Umbas RIZAL A HAMID, RIZAL A Rochani Sumardi, Rochani Siti A Nuhonni, Siti A Siti Setiati SITUMORANG, GERHARD R Untung Tranggono, Untung WIDIA, FINA YEVRI ZULFIKAR, YEVRI Zulfikar Ali, Zulfikar