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EXTRACTION OF PHENOLIC COMPOUNDS FROM PETAI LEAVES (PARKIA SPECIOSA HASSK.) USING MICROWAVE AND ULTRASOUND ASSISTED METHODS Buanasari, Buanasari; Eden, Willy Tirza; Sholichah, Ayu Ina
Jurnal Bahan Alam Terbarukan Vol 6, No 1 (2017): June 2017 [Nationally Accredited]
Publisher : Semarang State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jbat.v6i1.7793

The antioxidant has an activity to neutralize free radical compound that the body needs to avoid damage cells and tissues. Phenolic is one of the compounds that have an antioxidant activity. The influences of ultrasonic-assisted extraction (UAE) and microwave-assisted extraction (MAE) conditions on phenolic compounds of Parkia speciosa Hassk. leaves were investigated. The effects of temperature (40Â°C, 50Â°C, 60Â°C and 70Â°C), time (10, 30 and 50 minutes) and material-solvent ratio (1:10, 1:13, 1:15 ) were evaluated based on the yield, total phenolic content (TPC) and antioxidant activity. The result showed that the highest yield (15.82%) was obtained at 1:15 (w/w) of material-solvent ratio, 50Â°C of temperature and 50 minutes of extraction time for MAE. The highest yield of UAE is 15.53% that sample was obtained at 1:13 (w/w) of material-solvent ratio, 60Â°C of optimal temperature and 30 minutes extraction time. The highest IC50 of UAE method extract was 52.55 ppm, while the extract obtained using MAE method was 50.44 ppm. UAE is more stable at higher temperatures. Time and solvent which was used more efficient than MAE. Extract of petai leaves (Parkia speciosa Hassk.) were very potential to be used as a source of natural antioxidants because they have IC50 values from 41.39 to 66.00 ppm. Its antioxidants capacity is ranged from strong to very strong capacity.

Profil Fitokimia dan Aktivitas Antioksidan Beberapa Tumbuhan Genus Artocarpus di Indonesia Ayu Ina Solichah; Khoerul Anwar; Abdul Rohman; Nanang Fakhrudin
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2026

Artocarpus merupakan tumbuhan genus utama keluarga Moraceae dengan jumlah spesies hampir 1.400. Beberapa spesies dari genus tersebut dapat dimanfaatkan sebagai makanan dan obat tradisional di Asia Tenggara, termasuk Indonesia. Jenis yang banyak tumbuh di Indonesia yaitu Artocarpus altilis (sukun), Artocarpus camansi (kluwih), Artocarpus heterophyllus (nangka), Artocarpus integer (cempedak), dan Artocarpus odoratissimus (tarap). Tumbuhan tersebut memiliki potensi sebagai bahan obat dan punya nilai gizi yang tinggi. Review ini bertujuan untuk mengkaji perbedaan antar spesies, profil fitokimia, dan aktivitasnya sebagai antioksidan dari kelima tumbuhan tersebut. Narrative review ini ditulis berdasarkan penelusuran literatur yang berupa publikasi artikel penelitian yang ada di basis data Google Scholar, PubMed, dan Science Direct. Selain itu digunakan sumber pustaka lain berupa buku dan naskah tugas akhir untuk memperkaya isi artikel. Hasil kajian literatur terhadap 5 tumbuhan tersebut menunjukkan bahwa beberapa tumbuhan memiliki kemiripan morfologi daun walaupun secara fisik masih bisa dibedakan. Profil fitokimianya memiliki keunikan dengan kandungan utama berupa senyawa fenolik termasuk flavonoid, stilbenoid, arilbenzofuron, dan neolignan yang tersebar pada bagian daun, buah, bunga, dan kulit. Keunikan tersebut ditemui dengan adanya senyawa golongan flavonoid terprenilasi dan tergeranilasi. Senyawa fenolik tersebut mempunyai kemampuan sebagai antioksidan pada beberapa model uji dan potensial untuk dikembangakan sebagai antioksidan atau kandidat obat terutama untuk penyakit yang melibatkan mekanisme radikal bebas dalam mekanisme patofisiologinya.

Peningkatan Mutu Tanaman Obat Keluarga (TOGA) untuk Meningkatkan Imunitasi pada Masa Pandemi Covid-19 di Desa Kalisegoro Kecamatan Gunungpati Kota Semarang Atalia Tamo Ina Bulu; Ayu Ina Solichah; Wahyu Setiyaningsih; Sandi Mahesa
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 2, No 3 (2022): Abdira, Juli
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i3.188

TOGA is a restorative plant that can be used locally. This plant, if used and applied appropriately and accurately, will have an impact on the surrounding environment, especially during the COVID-19 pandemic. A good use of TOGA can directly affect a person's endurance. The aim is to provide an understanding to the public about TOGA (Family Medicinal Plants) which can improve health in the community. The implementation of community service activities is carried out using counseling and demonstration methods. The place used is a resident's house in the village of RW 2, Kalisegoro Village, Gunungpati District, Semarang City. The activity was held on May 15, 2022 with 50 female participants. Results Community service activities went well and smoothly starting from licensing to the implementation process of counseling and closing. Conclusion Participants get direct benefits on how to apply TOGA (Family Medicinal Plants) to increase immunity.

Formulasi dan Uji Aktivitas Antibakteri Nanoemulsi Mouthwash Ekstrak Etanol Daun Jeringau (Acorus calamus Linn.): Formulation and Antimicrobial Activity of Jeringau Leaves Extract (Acorus calamus Linn.) Nanoemulsion Mouthwash Nurista Dida Ayuningtyas; Ayu Ina Solichah; Rizky Nur Fadhilah; Tri Subekti
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1694

Ekstrak daun jeringau telah diketahui mengandung flavonoid dan saponin serta berkhasiat antibakteri. Potensi tersebut dapat dikembangkan menjadi sediaan farmasi yang lebih praktis yaitu nanoemulsi mouthwash. Tujuan penelitian ini adalah memformulasikan komponen nanoemulsi dan uji aktivitas antibakteri pada formula nanoemulsi yang baik. Nanoemulsi dibuat menggunakan variasi IPM:Tween 80:Propilenglikol dengan perbandingan F1 (1:8:1); F2 (2,15:5,7:2,15); dan F3 (3,25:5,2:1,55). Pengujian nanoemulsi yaitu organoleptis, sentrifugasi, transmitan, pH, viskositas, dan bobot jenis. Formula terbaik dilanjutkan dengan pengujian ukuran partikel, zeta potensial dan aktivitas antibakteri metode disc diffusion. Pengujian organoleptis pada F1 dan 3 stabil selama 7 hari sediaan tetap jernih dan tidak mengalami pemisahan fase, sedangkan F2 terjadi creaming. Uji transmitan F1-3 96,8%+0,00; 95,9%+0,00; dan 96,73+0,06. pH F1-3 5,92+0,02; 5,89+0,01; dan 5,92+0,01. Viskositas F1-3 1,681 Cps +0,02; 1,460 Cps +0,01; dan 1,533 Cps+0,03. Bobot jenis F1-3 sebesar 1,030 g/mL; 1,026 g/mL; dan 1,026+ g/mL. F3 dipilih sebagai formula yang baik, hasil uji ukuran partikel 239,97+ 3,45 nm dan zeta potensial -30,5+1,11 mV. Nanoemulsi mouthwash ekstrak etanol daun jeringau 1% memiliki aktivitas antibakteri terhadap Streptococcus mutans dengan diameter daya hambat 30,33+0,58 mm yang hampir sama dengan diameter daya hambat Clindamysin sebagai kontrol positif sebesar 33+1,00 mm.

Standardisasi dan Skrining Fitokimia Ekstrak Daun Singkil (Premna corymbose) Margareta Retno Priamsari; Ayu Ina Solichah; Icha Yuliska Aminah
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p76-80

Standardization is needed to obtain uniform raw materials that can guarantee the pharmacological effects of singkil plants. Phytochemical screening is the initial stage in a phytochemical research that aims to provide an overview of the class of compounds contained in the plant under study. The purpose of this study was to determine the standardization profile and class of chemical compounds in the ethanol extract of singkil leaves. This type of experimental research. Singkil leaf extraction was carried out by maceration method with 70% ethanol solvent, then followed by standardization test of singkil leaf ethanol extract. The next step is testing phytochemical compounds by identifying alkaloids, flavonoids, saponins, tannins, triterpenoids/steroids through phytochemical screening which are analyzed descriptively.The standardization results showed that the ethanol extract of singkil leaves had a dry shrinkage of 3.43%±1.28% (w/w), the extract content was soluble in water in singkil leaf powder was 20.01%±0.22% (v/w), the water soluble extract content of singkil leaf extract was 19.81 ± 0.22% (v/w), the ethanol soluble extract content of singkil leaf powder was 24.48 ± 0.24 %(v/w), ethanol soluble extract content of singkil leaf extract was 26.88 ± 1.16 %(v/w), specific gravity of singkil leaf extract was 0.91 ± 0.00 %(v/v), and ash content of singkil leaf extract. was 30.40 ± 0.00 %(w/w). The results of phytochemical screening showed that the ethanolic extract of singkil leaves contained flavonoids, tannins, saponins and triterpenoids

Aktivitas Ekstrak Etanol Daun Akar Kucing (Acalypha indica L.) Sebagai Pengawet Alami Pada Buah Tomat (Lycopersium esculentum Mill.) Ayu Ina Solichah; Rizky Ardian Hartanto Sawal; Fitri Auliya
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p120-125

The presence of preservatives in food is a common thing to extend the shelf life of foods. The bad effects appliying chemical preservatives cause both environmental pollution and health disturbing. Consuming chemical preservatives for a long time will will cause cancer. Natural preservatives is needed to reducing the bad effects. One of the Plants can be applied as natural preservatives is cat root leaves (Acalypha indica L. The study aims were to determine the activity and effective concentration of cat root leaf extract as a natural preservative on tomatoes and to identify the its phytochemical content. Activity of cat root leaf extract as a preservative was subjected by organoleptic, meanwhile the phytochemical content by tube-test. The results showed 8% cat root leaf extract effective as natural preservative according to organoleptic observation with observed time for 20 days. The result of tube-test showed cat root leaf extract contain compounds likes alkaloid, flavonoid, saponin, tannin, and terpenoid.

Profil Fitokimia dan Aktivitas Antioksidan Beberapa Tumbuhan Genus Artocarpus di Indonesia Ayu Ina Solichah; Khoerul Anwar; Abdul Rohman; Nanang Fakhrudin
Journal of Food and Pharmaceutical Sciences Vol 9, No 2 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2026

Artocarpus merupakan tumbuhan genus utama keluarga Moraceae dengan jumlah spesies hampir 1.400. Beberapa spesies dari genus tersebut dapat dimanfaatkan sebagai makanan dan obat tradisional di Asia Tenggara, termasuk Indonesia. Jenis yang banyak tumbuh di Indonesia yaitu Artocarpus altilis (sukun), Artocarpus camansi (kluwih), Artocarpus heterophyllus (nangka), Artocarpus integer (cempedak), dan Artocarpus odoratissimus (tarap). Tumbuhan tersebut memiliki potensi sebagai bahan obat dan punya nilai gizi yang tinggi. Review ini bertujuan untuk mengkaji perbedaan antar spesies, profil fitokimia, dan aktivitasnya sebagai antioksidan dari kelima tumbuhan tersebut. Narrative review ini ditulis berdasarkan penelusuran literatur yang berupa publikasi artikel penelitian yang ada di basis data Google Scholar, PubMed, dan Science Direct. Selain itu digunakan sumber pustaka lain berupa buku dan naskah tugas akhir untuk memperkaya isi artikel. Hasil kajian literatur terhadap 5 tumbuhan tersebut menunjukkan bahwa beberapa tumbuhan memiliki kemiripan morfologi daun walaupun secara fisik masih bisa dibedakan. Profil fitokimianya memiliki keunikan dengan kandungan utama berupa senyawa fenolik termasuk flavonoid, stilbenoid, arilbenzofuron, dan neolignan yang tersebar pada bagian daun, buah, bunga, dan kulit. Keunikan tersebut ditemui dengan adanya senyawa golongan flavonoid terprenilasi dan tergeranilasi. Senyawa fenolik tersebut mempunyai kemampuan sebagai antioksidan pada beberapa model uji dan potensial untuk dikembangakan sebagai antioksidan atau kandidat obat terutama untuk penyakit yang melibatkan mekanisme radikal bebas dalam mekanisme patofisiologinya.

Tingkat Pengetahuan Masyarakat Terhadap Ketepatan Swamedikasi Obat Anti Jamur di Apotek Ferika Indrasari; Novita Indah Permata Dewi; Agustina Ratna Wulandari; Ayu Ina Solichah
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p174-179

Antifungal is a class of drugs that are fungicidal or fungistatic, these drugs can be used to treat and prevent mycoses such as water fleas, ringworm. People around Wahyu Farma Pharmacy often experience itching caused by fungi or allergies. One treatment that is often done by the community is self-medication (self-medication). In self-medication, the community needs good knowledge so that self-medication can have a positive impact. The purpose of this study was to determine the level of public knowledge about the accuracy of self-medication of antifungal drugs at the Wahyu Farma Pharmacy in the Jepon area of Blora City. This type of research is a non-experimental descriptive with a quantitative approach. This study uses purposive sampling method with a questionnaire measuring instrument to 95 respondents. The data obtained is primary data from the results of filling out questionnaires distributed to the community who are self-medication of antifungal drugs. The results of the study showed that the level of knowledge about self-medication was 79.47% classified as sufficient, the right category of drugs 71.57% was sufficient, the right dose was 73.15% sufficient category, on time 67.36% sufficient category, alert for side effects 62, 10% is sufficient. The total percentage of self-medication, right drug, right dose, right drug, on time, alert for side effects is 70.73% which means that they are knowledgeable enough.

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