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RA Kisdjamiatun RMD, RA Kisdjamiatun
Magister Ilmu Biomedik Universitas Diponegoro
Health Professions

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Pengaruh jamur tiram putih (pleurotus ostreatus) terhadap kadar glukosa darah, profil lipid dan kadar MDA pada tikus (rattus norvegicus) diabetes melitus Purbowati, Purbowati; Johan, Andrew; RMD, RA Kisdjamiatun
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 2 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.291 KB) | DOI: 10.14710/jgi.4.2.131-137

Abstract

Background : Diabetes mellitus is a chronic disease caused by acquired deficiency in insulin production by the pancreas, or by the ineffectiveness of using the produced insulin. Oyster mushroom (Pleurotus ostreatus) can help lower blood glucose levels, improve lipid profile and reduce levels of MDA.Objective : to analyze the effect of oyster mushroom on blood glucose levels, lipid profile and MDA levels in STZ induced rats as type 1 DM model. Methods : thirty Sprague Dawley rats were randomly divided into 3 groups: one positive group (1) and two treated group which received 100 mg/kgBB (2) and 200 mg/kgBB (3) oyster mushroom extract, respectively. The interventions were carried out for 30 days. The examination of blood glucose levels, lipid profile and MDA levels was before and after the intervention. The differences inthe datapre-post interventions were analyzed by paired t-test, whereas the differences between the groups were analyzed by one-way ANOVA and kruskal wallis followed by post hoc analysis. Results : the treatment group experienced a decrease in blood glucose levels, total cholesterol, LDL cholesterol, triglycerides, MDA and an increase in HDL cholesterol levels post-intervention (p < 0,001). Oyster mushroom extract with the dose of 200 mg/kg was more effective in lowering blood glucose levels, MDA levels and improving lipid profiles (p < 0,001).Conclusion : Oyster mushrooms administration lowers blood glucose levels, total cholesterol, LDL cholesterol, triglycerides, MDA and increases HDL cholesterol levels. 
Pengaruh pemberian seng terhadap indeks fagositosis makrofag dan kadar nitric oxyde mencit balb/c yang terpapar lipopolisakarida e.coli Fardian, Nur; Johan, Andrew; RMD, RA Kisdjamiatun
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 2 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.58 KB) | DOI: 10.14710/jgi.3.2.68-72

Abstract

Latar Belakang : Sistem imun tubuh merespons LPS dengan mengaktifkan makrofag dan memproduksi NO. Seng memiliki sifat sebagai antioksidan dan imunomodulator. Penelitian bertujuan untuk membuktikan pemberian seng berbagai dosis berpengaruh terhadap indeks fagositosis makrofag dan kadar NO.Metode : The post test only controlled group design pada mencit Balb/C terbagi atas 4 kelompok. Perbedaan indeks fagositosis dan kadar NO dianalisis menggunakan uji one way ANOVA dan dilanjutkan dengan uji Bonferroni. Hasil : Rerata indeks fagositosis makrofag adalah 106,60(±023,31), 428,40(±159,58), 285,70(±90,45) dan 208,07(±43,85) berturut turut untuk kelompok kontrol, perlakuan dosis 30 ppm, perlakuan dosis 60 ppm dan perlakuan dosis 120 ppm. Terdapat perbedaan bermakna atas indeks fagositosis makrofag antara kelompok kontrol dan perlakuan (p = 0,000). Rerata kadar NO adalah 0,08(±0,03), 0,12(±0.06), 0,09(±0,03) dan 0,20±0,08 berturut turut untuk kelompok kontrol, perlakuan dosis 30 ppm, perlakuan dosis 60 ppm dan perlakuan dosis 120 ppm. Terdapat perbedaan bermakna atas kadar NO antara kelompok kontrol dan perlakuan (p= 0,013).Kesimpulan : Indeks fagositosis makrofag seluruh kelompok perlakuan dengan dosis seng bertingkat 30 ppm, 60 ppm dan 120 ppm lebih tinggi secara bermakna dibanding kelompok kontrol. Kadar NO kelompok perlakuan dengan dosis seng 120 ppm lebih tinggi secara bermakna dibanding kelompok kontrol. Sedangkan dosis pemberian seng 30 ppm terbukti memiliki indeks fagositosis tertinggi dan dosis 120 ppm terbukti memiliki kadar NO tertinggi.
Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 Yasin, Yade Kurnia; Kartasurya, Martha Irene; RMD, RA Kisdjamiatun
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 4, No 1 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.546 KB) | DOI: 10.14710/jgi.4.1.1-8

Abstract

Background: Malondialdehyde (MDA) levels produced by oxidative stress in type 2 diabetes mellitus (T2DM) is higher than in non diabetes patients. Vitamin C and E inhibit oxidative stress and MDA production. The purpose of this study was to prove the effects of combined vitamin C and vitamin E on MDA plasma levels in T2DM patients.Methods: This double blind randomized pre post test control group design was carried out on 35 patients with T2DM without complication (age 40-60 yr) in Makassar. The treatment group (n=18) received vitamin C 250 mg/day plus vitamin E 400 IU/day and the control group (n=17) received placebo (seaweed powder 250 mg), for six weeks. Vitamin C was consumed before meal and vitamin E after meal. MDA levels were measured before and after supplementation by using TBARs method. Food intake and activity were derived from 24-hour recall method.Results: There was no different on MDA levels at baseline (p=0.151). At the end of the study, MDA levels increased in control group (5.8±2.74 to 7.2±3.00 nmol/ml; p=0.044) but not in the treatment group (7.2±2.88 to 7.7±2.02 nmol/ml; p=0.490). There was no difference in MDA alteration between the goups (p=0.316). There was no different in MDA levels at the end of the study (p=0.061) and confirmed after controlling the confounding variables: vitamin E intake and fasting blood glucose (p=0.809). Conclusion: Combined vitamin C 250 mg and vitamin E 400 IU for 6 weeks did not reduce MDA levels, but inhibit MDA production in T2DM patients.
Co-Authors Andrew Johan Martha Irene Kartasurya Nur Fardian, Nur Purbowati, Purbowati Yade Kurnia Yasin, Yade Kurnia