Siti Surdijati, Siti
Department of Medical Pharmacy, Faculty of Pharmacy, Unika Widya Mandala Surabaya

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Pengaruh Pemberian Infus Kelopak Kering Rosella (Hibiscus sabdariffa) Terhadap Kadar Kolesterol Total Serum Darah Tikus Hiperkolesterolemia Octavia, Stefani Kartika; Surdijati, Siti; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (939.618 KB) | DOI: 10.33508/jfst.v2i2.715

Abstract

Rosella (Hibiscus sabdariffa) merupakan salah satu tanaman bermanfaat sebagai bahan makanan, minuman maupun bahan obat. Kelopak Rosella berkhasiat sebagai antihipertensi, antidiabetes, antikolesterol, terapi gangguan liver dan asam urat. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh yang signifikan dari pemberian infus kelopak kering Rosella dalam menurunkan kadar kolesterol total serum darah tikus hiperkolesterolemia. Penelitian ini menggunakan 25 tikus putih jantan galur Wistar yang diberi propiltiourasil 0,01% dan makanan tinggi kolesterol selama 2 minggu. Kemudian dibagi dalam lima kelompok, yaitu kontrol (PGA 3%), pembanding (Simvastatin 0,9 mg/kgBB) dan 3 kelompok uji yang diberi infus Rosella dosis 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB, secara oral selama 2 minggu. Data dianalisis dengan uji statistik Anova dilanjutkan uji Tukey HSD 5%. Perhitungan korelasi digunakan untuk mengetahui hubungan antara peningkatan dosis dengan penurunan kolesterol total. Tidak ada perbedaan bermakna pada setiap pasangan kelompok dengan signifikansi >0,05 untuk semua kelompok kecuali antara K1 dan K5 (signifikansi
Studi Penggunaan Omeprazole pada Pasien Sirosis Hati dengan Hemetamesis Melena Rawat Inap di RSUD Kabupaten Sidoarjo Wiranata, I Made; Hasmono, Didik; Surdijati, Siti
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (495.556 KB) | DOI: 10.33508/jfst.v4i1.2177

Abstract

Liver cirrhosis is a process of liver cell damage which later becomes fibrosis tissue. Then, the occurrence of liver structural distortion and increased vascularization to the liver resulting in varicose veins or dilation of blood vessels in the gastrointestinal and esophageal areas. Patients with esophageal varices, there is a risk of bleeding from esophageal rupture, the undergone hematemesis (vomiting of blood) and melena (blackish defecate). The therapies used to reduce gastrointestinal bleeding are gastric ulcers drugs such as H2Ras and PPI. The study aimed to determine the pattern of omeprazole use in liver cirrhosis patients with hematemesis melena. The method used was an observational retrospective study in medic record data patients. Sampling was done by consecutive sampling, the period of Juli 1, 2015 until Descember 31, 2015. The results obtained from the study were single use of omeprazole with a dose of 2x40mg/i.v used the most by 22 patients (73.3%). The use of omeprazole with a dose of 2x40mg/i.v combined with other gastric ulcer drugs was 7 patients (23.3%), omeprazole with ranitidin 6 patients, omeprazole with antacid for 1 patient. The use of omeprazole with a dose of 2x40mg was replaced with ranitidin 2x25mg/ml was 1 patient (3.3%). The use of omeprazole given in liver cirrhosis patients with hematemesis melena at the Inpatient Installation of Regional Hospital of Sidoarjo, related dose, route, frequency, interval, and duration of giving was in appropriate with the guidelines contained in the National Formulary.
Pola Penggunaan Levofloxacin pada Pasien HIV dan AIDS di UPIPI RSUD DR. Soetomo Surabaya Pambudi, Rien Esti; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.807 KB) | DOI: 10.33508/jfst.v5i2.2142

Abstract

HIV is a retrovirus (RNA) that attacks the human immune system. AIDS is a retrovirus disease characterized by immunosuppression which causes opportunistic infectious diseases. Opportunistic infections appear with new forms of infection by other microorganisms or reactivation of latent infections under normal conditions that can be controlled by the immune system so as not to cause manifestations. Opportunistic infections show effects on immunity associated with CD4 cell counts. The therapy used to reduce opportunistic infections is levofloxacin. Based on research, levofloxacin for HIV AIDS patients is often used to reduce opportunistic infections including bacterial pneumonia, tuberculosis and sepsis. This study aims to provide data that includes levofloxacin therapeutic doses, frequency use, old route drugs, prevalence and interaction of qualitative analysis related to medical records in HIV & AIDS patients at UPIPI DR. Soetomo Regional General Hospital Surabaya. The research method used is a retrospective observational study on medical records of patients with HIV & AIDS. Sampling was done by consecutive sampling in the period January 1, 2015 to June 30, 2015. The results obtained from the most relevant types of research, dose, frequency and route were levofloxacin for the treatment of opportunistic infections, especially bacterial pneumonia, tuberculosis, and sepsis. in oral doses and injections at a dose of 500 mg and a frequency of 750 mg 1x1. The use of levofloxacin given to HIV & AIDS patients at UPIPI DR. Surabaya Soetomo Regional General Hospital, related to dosage, route, frequency, interval, and duration of administration is in accordance with existing guidelines.
Pola Penggunaan Ranitidine pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Nurohmawati, Weni; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.527 KB) | DOI: 10.33508/jfst.v4i2.2182

Abstract

HIV is a retrovirus that attacks CD4 lymphocyte cells. AIDS is a retrovirus disease caused by infection with retrovirus HIV-1 or HIV-2 which causes opportunistic diseases, secondary neoplasms and neurological abnormalities. In patients with HIV & AIDS often experience gastrointestinal disorders such as nausea and vomiting caused by side effects of the use of antiretroviral or due to other factors. Ranitidine is an H2 inhibitory receptor that will selectively and reversibly reduce excess gastric acid secretion. In this study ranitidine was used as a stress ulcer prophylaxis in hospitalized patients. This study aims to display ranitidine therapy data including type, dose, route of drug administration, prevalence, duration of use and qualitative analysis of interactions associated with medical record data at UPIPI RSUD Dr. Soetomo Surabaya. The research method used was observational prospectively on patient medical record with HIV & AIDS. Sampling was carried out by consecutive sampling period from November 1, 2016 to December 31, 2016. The results of this study give information that ranitidine was most widely used for stress ulcer prophylaxis therapy in hospitalized patients in UPIPI RSUD Dr. Soetomo Surabaya in a dose of 50mg / 2ml with a frequency of 2x1 while for oral ranitidine with a dose of 150mg / tablet with a frequency of 2x1. The use of ranitidine on HIV & AIDS patients in UPIPI RSUD Dr Soetomo Surabaya, related to dosage, route, frequency, interval, and duration of administration is in accordance with the existing guidelines.
Studi Penggunaan Antiemetik pada Pasien Demam Tifoid Rawat Inap di RSUD Kabupaten Sidoarjo Wardhani, Hety Setya; Surdijati, Siti; Hasmono, Didik
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.33508/jfst.v4i1.2175

Abstract

Typhoid fever is an infection of the small intestine caused by Salmonella thypi bacteria with symptoms of fever at night. This disease is a contagious disease that can affect many people and is still a health problem, especially in developing countries. This study aims to analyze patterns of antiemetic use in typhoid fever patients. This research was conducted at Sidoarjo District General Hospital using a retrospective method in the period of January 1 to December 31, 2015. The sample was typhoid fever patients who were treated at the Sidoarjo District Hospital. The results obtained using the Health Medical Record (RMK) of patients who have been validated, 161 patients was detected and only 30 patients who is using antiemetic therapy. The antiemetic used is ondansetron. Ondansetron in single dose (3x4mg) iv used in 7 patients (23%) and (3x8mg) iv in 23 patients (77%). The duration of ondansetron use in typhoid fever patients in Sidoarjo District Hospital ≤ 2 days was 10 patients and ≥ 2 days was 20 patients. Antiemetics used were in accordance with the guidelines and no Drug Related Problems (DRPs) were obtained in typhoid fever patients as seen from their interactions with other drugs, the interval of administration, frequency of administration, duration of treatment, and dose of administration.
Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya Bura, Ursula Dua Klowe; Hasmono, Didik; Surdijati, Siti; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.933 KB) | DOI: 10.33508/jfst.v4i2.2185

Abstract

Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of ≤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patient’s blood pressure mostly meets the target of ≤ 140 mmHg.
EFEK SUPLEMENTASI VIRGIN COCONUT OIL TERHADAP PARAMETER METABOLIK DAN ANTROPOMETRIK TIKUS WISTAR JANTAN OBESITAS Wijaya, Hendy; Surdijati, Siti
Journal of Nutrition College Vol 9, No 1 (2020): Januari
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4976.745 KB) | DOI: 10.14710/jnc.v9i1.25324

Abstract

Latar Belakang: Untuk mengatasi masalah obesitas ada banyak program modifikasi gaya hidup melalui pengaturan pola makan dan peningkatan aktivitas fisik. Di antara program diet dikenal diet rendah lemak serta derivatnya dan diet rendah karbohidrat. Beberapa penelitian menunjukkan bahwa efek positif diet rendah karbohidrat sebagian besar diperantarai oleh keton dalam darah. Selain dapat berfungsi sebagai sumber energi alternatif yang efisien, keton dapat berperan juga sebagai molekul sinyal yang dapat mempengaruhi metabolisme sel dan perilaku. Virgin Coconut Oil (VCO) adalah sumber asam lemak rantai sedang alamiah dengan kuantitas dan kualitas tinggi yang dapat diserap dan dimetabolisme di dalam liver dengan mudah dan cepat menjadi keton Tujuan: Penelitian ini dilakukan untuk mengetahui efek suplementasi virgin coconut oil terhadap kadar glukosa darah, keton darah, asupan makanan, massa lemak viseral dan berat badan pada model obesitas yang diinduksi melalui diet tinggi lemak-sukrosa.Metode: Tiga puluh dua subyek tikus wistar jantan yang sebelumnya sudah dibuat obesitas (indeks Lee >0,300) melalui diet tinggi lemak-sukrosa selama 20 minggu dibagi ke dalam empat kelompok. Kelompok (A) mendapat akuades per oral, kelompok (S) mendapat larutan sukrosa per oral, kelompok (VCO) mendapat VCO per oral, dan kelompok (CO) mendapat minyak jagung per oral selama 4 minggu, diberikan sebelum makan pada siklus malam tikus.Hasil: Hasil penelitian menunjukkan tidak ada perbedaan bermakna pada kadar glukosa darah, massa lemak viseral dan berat badan antar kelompok subyek. Hasil penelitian menunjukkan bahwa pemberian virgin coconut oil dapat meningkatkan kadar keton darah dan menurunkan asupan makanan (p=0,023 dan p=0,000) dibandingkan dengan kelompok perlakuan lain.Simpulan: Hasil penelitian menunjukkan bahwa suplementasi VCO sebelum makan dapat meningkatkan kadar keton darah dan menekan asupan makanan tikus obesitas yang diinduksi diet tinggi lemak-sukros. Namun, penurunan asupan makanan tampaknya tidak dipengaruhi oleh kadar keton dalam darah.
Pengaruh Komunikasi, Informasi dan Edukasi (KIE) terhadap Tingkat Pengetahuan Pasien Pediatri Penyakit Diare di Puskesmas “X” Wilayah Surabaya Timur Missa, Margareta Maria Alacoque; Surdijati, Siti; Trisnani, Retno
Jurnal Farmasi Sains dan Terapan Vol 7, No 2 (2020): Oktober
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v7i2.2794

Abstract

Diare merupakan salah satu masalah kesehatan yang masih sering menjadi Kejadian Luar Biasa ( KLB ) karena dapat menyebabkan kematian. Penyebab utama kematian diare adalah dehidrasi akibat kehilangan cairan dan elektrolit melalui feses. Penyakit diare masih menjadi masalah global dengan derajat kesakitan dan kematian yang tinggi di berbagai negara terutama di negara berkembang. Penelitian ini bertujuan untuk mengetahui pengaruh dari Komunikasi Informasi dan Edukasi (KIE) terhadap tingkat pengetahuan pasien penyakit diare di Puskesmas “X” Wilayah Surabaya Timur periode Maret hingga Agustus 2019. Penelitian bersifat deskriptif dan Analisis metode paired sample T test dengan pengambilan data secara purposive sampling. Sumber data adalah pasien pediatri penyakit diare dengan rentang usia 0-17 tahun. Hasil penelitian dari 40 responden yang memenuhi kriteria inklusi, yaitu jumlah responden berjenis kelamin laki-laki (7,5%) dan perempuan (92,5%), sebagian besar berusia 31-35 tahun (47,5%) dan 25-30 tahun (27,5%). Hasil penelitian menunjukkan bahwa dari 40 responden yang memenuhi kriteria inklusi sebelum KIE diperoleh tingkat pengetahuan baik (15%), tingkat pengetahuan cukup (77 %) , dan tingkat pengetahuan kurang sebesar (7,5 %). Sesudah KIE diperoleh tingkat pengetahuan baik (75%), dan tingkat pengetahuan cukup (25%). Berdasarkan hasil penelitian terdapat hubungan antara tingkat pengetahuan dengan pemberian Komunikasi Informasi dan Edukasi (KIE) terhadap pasien pediatri penyakit diare yang dilakukan di puskesmas “X” Wilayah Surabaya Timur.