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All Journal Jurnal Ilmiah Farmasi INDONESIAN JOURNAL OF PHARMACY
Purwantiningsih Purwantiningsih
Departement Of Pharmacological, Faculty Of Pharmay, University Of Gadjah Mada, Indonesia
Medicine & Pharmacology

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EFFECT OF THE JUICE OF GINGER RHIZOMES ON THE PHARMACOKINETICS OF SULFAMEZATHINE IN RATS ., Purwantiningsih; Hakim, Lukman
INDONESIAN JOURNAL OF PHARMACY Vol 14 No 1, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.267 KB) | DOI: 10.14499/indonesianjpharm0iss0pp250-255

Abstract

The rhizome of ginger (Zingiber officinale, Rosc.) has been widely consumed by people as food ingredient or a traditional drug. In the previous research there was evidence that the ginger juice influenced the pharmacokinetics of propranolol, a representative of drugs with high extraction ratio. The aim of this research is to study the effect of ginger juice on another high ER drug, sulfamezathine. To achieve the aim of this study, rats were divided into two groups to get the blood and urine data. The animals at the blood data group were divided into two groups. The group I (N=6) was given sulfamezathine (50 mg/kg BW) through intra peritoneal injection and the group II (N=6) was pretreated with the ginger juice orally (4 ml/kg BW) an hour prior to administration of sulfamezathine. The blood samples were withdrawn at various intervals after the drug administration. The unchanged sulfamezathine concentration was determined using a modified Bratton-Marshall method. From this blood data the values of Ka, Cmaks, Tmaks, Vdss, AUC, Cl and T1/2el were computed. Urine data was obtained by using two groups of rats with the same treatment as above. The sulfamezathine was counted from urine which accumulated for 24 hours to obtain the value of Fel. The results of this research showed that significant decreases in Cmaks (16.72%) and AUC (22.92%) values have occurred, with increasing values of Vdss (18.39%), ClT (38.29%), ClR (213.11%) and Fel 24 hours (128.58%) values. Key words : ginger rhizome, pharmacokinetics, sulfamezathine, rats
EFEK ANALGESIK FRAKSI ETANOL DARI EKSTRAK ETANOL DAUN MINDI (Melia azedarach L.) PADA MENCIT JANTAN Indah Purwantini,; Purwantiningsih Purwantiningsih; Oktavia Eka Puspita
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTIndonesia has a lot of traditional medicines, which people used long time ago, one of theseis mindi (Melia azedarach L.). It have been known that ethanolic extract of mindi leaves hasanalgesic effect greater than paracetamol at dose 6.44 mg/kgBW and 12.89 mg/kgBW. Thisresearch conducted to find out the effectiveness ethanolic fraction of ethanolic extract as ananalgesic. The research was carried out in completely random one way design, used 35 micewhich have been fasted for 24 hours. The mice were divided into 7 groups i.e. negative control,positive control and 5 testing groups (in different doses). Fifteen minutes after injected with thefractions of mindi, the mice were given acetic acid 0.5% intraperitoneally injection. The cumulativewrithe reflects were calculated in every 5 minutes for one hour and were counted the protectionpercentage. Results showed that the ethanol fractions doses 12,88-103,04 mg/kgBW of mindileaves have the analgesic effect in mice and gave protection percentage 30.93-71.61%. Thechromatograms of TLC indicated that the fraction contain flavonoids and phenolic compounds.Key words: ethanol fraction of mindi, analgesic effect, TLC profile
Co-Authors Indah Purwantini, Lukman Hakim Oktavia Eka Puspita