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All Journal INDONESIAN JOURNAL OF PHARMACY
Ibnu G Gandjar, Ibnu G
Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia
Medicine & Pharmacology

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Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa [Phaleria macrocarpa (scheff). Boerl.] leaves Hartati W, Mae Sri; Mubarika, Sofia; Gandjar, Ibnu G; Hamann, Mark T; Rao, KV; Wahyuono, Subagus
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.086 KB) | DOI: 10.14499/indonesianjpharm0iss0pp51-57

Abstract

Mahkota Dewa [Phaleria macrocarpa (Scheff). Boerl.] is used traditionally to treat cancers in Indonesia. Extract methanol of the leaves displayed a small LC50 value (63.16 μg/ml) on BST (Brine Shrimp Lethality test) assay; therefore a phytochemical study of this extract was undertaken. A new benzophenoic glucoside was isolated from the methanol extract and identified as 4,5-dihydroxy,4’-methoxybenzophenone-3-0-β-D-glucoside (Phalerin) based on its spectroscopic data. Phalerin was cytotoxic to myeloma cell line (NS-1) (in vitro) having IC50 of 83 μg/ml or 1.9 x 10-1 mM.Key words: Phaleria macrocarpa, Phalerin, myeloma
Co-Authors KV Rao, KV Mae Sri Hartati Wahyuningsih Mark T Hamann, Mark T Sofia Mubarika H Subagus Wahyuono