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All Journal snimed Jurnal Ilmiah Farmasi Media Penelitian dan Pengembangan Kesehatan Journal of Educational, Health and Community Psychology Disease Prevention and Public Health Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Sari Pediatri Universa Medicina JURNAL ILMU KEFARMASIAN INDONESIA Refleksi Pembelajaran Inovatif Jurnal Aisyah : Jurnal Ilmu Kesehatan Automata JK Unila (Jurnal Kedokteran Universitas Lampung) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Ika Fidianingsih
Departemen Histologi, Fakultas Kedokteran, Universitas Islam Indonesia, Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Intermittent fasting decreases oxidative stress parameters in Wistar rats (Rattus norvegicus) Nurmasitoh, Titis; Utami, Shindy Yudha; Kusumawardani, Endah; Najmuddin, Abdulhalim Ahmad; Fidianingsih, Ika
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.31-38

Abstract

BackgroundChronic and degenerative diseases are closely related to modern lifestyles that tend to be deficient in physical activity but excessive in food intake. One method used to overcome this problem is dietary restriction through intermittent fasting. Intermittent fasting decreases the risk of chronic and degenerative diseases, e.g. by lowering oxidative stress. Oxidative stress can be determined from the malondialdehyde (MDA) levels and lipid profile in the blood. The present study aimed to determine the effect of intermittent fasting on plasma MDA levels and lipid profile of Wistar rats (Rattus norvegicus).MethodsThis research was a laboratory experimental research using a post test control group design. Twenty four male Wistar rats (Rattus norvegicus) were randomly assigned to 4 groups, ie control group (C), fasting group (F), non-fasting obese group (NFO), and fasting obese group (FO). Fasting treatment given in this research was intermittent fasting, comprising one day of fasting for 12 hours alternating with one day of normal feed ad libitum in the span of 8 weeks. After completion of treatment, blood was taken transcardially for examination of MDA levels and lipid profiles using spectrophotometry.ResultsThere were significant between-group differences in MDA levels and lipid profiles (p<0.05 for all parameters). Groups treated with intermittent fasting had lower levels of MDA, total cholesterol, triglycerides, and ow-density lipoprotein (LDL) than those without intermittent fasting. The high-density lipoprotein (HDL) levels were higher in the intermittent fasting group than the other groups.ConclusionIntermittent fasting has an effect on the oxidative stress parameters of Wistar rats (Rattus norvegicus).
Peningkatan Pengetahuan Warga Bromonilan untuk Mencegah Kejadian dan Komplikasi Diabetes Melitus Tipe II Kharisma, Muhammad; Fidianingsih, Ika; Sulistyoningrum, Evy
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 11, No 1 (2017): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.109 KB) | DOI: 10.12928/kesmas.v11i1.5213

Abstract

Background: Almost 80% of Diabetes Mellitus (DM) in the world is found in developing countries, and incidence of diabetes mellitus continues to increase, including in Indonesia. This disease will lead to decreased productivity and increased the economic burden in patient DM.  Bromonilan who suffer from DM is found the death of DM while the mortality rate of Bromonilan was unreported. The purpose of the study was to know the prevalence of Bromonilan’s DM. Method: A study was carried out in 80 of Bromonilan Villagers. All of the samples were measured the level of knowledge of DM through pretest and posted. Measuring glucose levels were also performed on 80 Bromonilan using rapid tests. Result: The prevalence of Bromonilan affected by DM was 10%. The level knowledge of DM increased 39.3% by intervention test. Conclusion: The prevalence of DM in Bromonilan was quite high. Integrated health services in community serve simultaneously to improve their knowledge such DM.
Age-related changes of malondialdehyde, body weight and organ weight in male mice Ahsani, Dwi Nur; Fidianingsih, Ika
Universa Medicina Vol 37, No 2 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.115-126

Abstract

IntroductionAging is characterized by gradual impairment in all physiological functions. Increases in free radicals and changes in organ morphology occur with aging. The purpose of this study was to determine age-related changes in serum free radicals, body weight, organ weights, and relative organ weights in male mice. MethodsAn experimental animal study was performed on 25 male mice (Mus musculus), which were randomized into 5 groups according to age at termination, i.e. 12 (group K1), 24 (K2), 32 (K3), 40 (K4) and 48 weeks (K5), respectively. Retro-orbital venous blood was taken for examination of malondialdehyde (MDA) levels. After termination, liver, heart, kidneys, testes, brain, thymus and spleen were weighed using an analytical balance. ANOVA and Kruskal Wallis tests were used to analyze the data, with p<0.05 being considered significant. ResultsSignificant changes were found with age in serum MDA level (p=0.000), body weight (p=0.000), and weights of all organs except thymus (p>0.05) (liver p=0.023, heart p=0.000, kidneys p=0.002, testes p=0.000, brain p=0.012 and spleen p=0.006). Significant changes in relative weight of brain (p=0.001) and spleen (p=0.049) were also found with age. ConclusionThis study demonstrated increases in serum MDA levels, body weight, and weights of the liver, heart, kidneys, testes, brain and spleen with age. Peak increases in weights of kidneys and thymus were found earlier than those in MDA levels and weights of other organs.
Peningkatan Pengetahuan Warga Bromonilan untuk Mencegah Kejadian dan Komplikasi Diabetes Melitus Tipe II Fidianingsih, Ika; Sulistyoningrum, Evy; Kharisma, Muhammad
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 11, No 1 (2017): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.109 KB) | DOI: 10.12928/kesmas.v11i1.5213

Abstract

Background: Almost 80% of Diabetes Mellitus (DM) in the world is found in developing countries, and incidence of diabetes mellitus continues to increase, including in Indonesia. This disease will lead to decreased productivity and increased the economic burden in patient DM.  Bromonilan who suffer from DM is found the death of DM while the mortality rate of Bromonilan was unreported. The purpose of the study was to know the prevalence of Bromonilan’s DM. Method: A study was carried out in 80 of Bromonilan Villagers. All of the samples were measured the level of knowledge of DM through pretest and posted. Measuring glucose levels were also performed on 80 Bromonilan using rapid tests. Result: The prevalence of Bromonilan affected by DM was 10%. The level knowledge of DM increased 39.3% by intervention test. Conclusion: The prevalence of DM in Bromonilan was quite high. Integrated health services in community serve simultaneously to improve their knowledge such DM.
Mild anxiety and depression related to elevated dopamine level Fidianingsih, Ika; Nurmasitoh, Titis; Arjana, Adika Zhulhi; Devita, Ninda; Khoiriyah, Umatul
Universa Medicina Vol 38, No 1 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (788.451 KB) | DOI: 10.18051/UnivMed.2019.v38.48-55

Abstract

BackgroundDopamine is an important neurotransmitter that plays a role in the pathogenesis of anxiety and depression. Dopamine secretion occurs when there is a pleasurable stimulus. Blood dopamine levels have the potential to be developed as biomarkers of depression or anxiety, but previous studies related to the relationship between dopamine levels and levels of anxiety and depression are still controversial. The purpose of this study was to determine the correlation between anxiety and depression score with dopamine level in young adults. MethodsThis was an observational cross sectional study. A total of 43 subjects aged 18 to 40 years were recruited by consecutive non-random sampling according to inclusion and exclusion criteria. Anxiety and depression were assessed using the Beck anxiety inventory and Beck depression inventory-II questionnaire. Dopamine plasma level was measured using the enzyme-linked immunosorbent assay (ELISA). The Spearman rho correlation test was used to analyze the data and p<0.05 was considered significant.Results The median dopamine levels in respondents with mild, moderate and severe anxiety were respectively: 77.79; 63.43; 62.51 ng/mL (p=0.043). The median dopamine levels in respondents with reasonable depression, mood disorder, moderate and severe depression were respectively: 79.2; 61,32; 62,51; 60.24 (p=0.001). Correlation test results showed a weak correlation between dopamine and anxiety (r=- 0.310) and a moderate correlation for depression (r=-0.505).ConclusionMild anxiety and depression were associated with elevated dopamine level in young adults. Further studies are required to confirm the role of dopamine metabolism in anxiety and depression in young adults.
Segmentasi Citra untuk Menentukan Skor Kerusakan Hati secara Histologi Nazarudin, Zohan; Muhimmah, Izzati; Fidianingsih, Ika
Seminar Nasional Informatika Medis (SNIMed) 2017
Publisher : Magister Teknik Informatika, Universitas Islam Indonesia

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Abstract

Penyakit hati menduduki urutan kedelapan penyebab kematian di Indonesia. Selama ini ahli histologi masih menggunakan cara manual untuk menghitung skor kerusakan  hati. Dengan teknik citra digital diharapkan akan ditemukan pola dan ciri khusus sehingga akan terbentuk sitem yang dapat menghitung skor kerusakan hati secara otomatis. Metode pengolahan citra yang di gunakan adalah segmentai citra, sedangkan untuk membandingkan hasil dari sistem dan perhitungan manual ahli digunakan uji kappa. Dari uji kappa yang dilakukan di ketahui rata-rata bernilai 0,61-0,80 sehingga keeratan kesepakatan kappa dikatakan kuat (good).
Pengaruh Pemberian Ekstrak Etanol Daun Pegagan (Centella asiatica) terhadap Gambaran Histopatologi Limpa Tikus (Rattus norvegicus) yang diinduksi Sodium Nitrit Sub Akut Afiqoh, Ainun Nur; Fidianingsih, Ika; Handayani, Ety Sari
Jurnal Kedokteran Universitas Lampung Vol 1, No 3 (2017): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v1i3.1668

Abstract

Sodium nitrit adalah senyawa garam yang secara luas digunakan sebagai pengawet dan pewarna merah daging. Konsumsi berlebihan dan dalam jangka waktu yang lama dapat menyebabkan terbentuknya senyawa karsinogenik dan terbentuk methemoglobin. Methemoglobin dapat menyebabkan terbentuknya Reactive Oxygen Species (ROS) yang dapat menyebabkan stres oksidatif pada berbagai sel tubuh salah satunya sel limfosit pada pulpa putih limpa. Sel limfosit yang berperan penting dalam sistem imun tubuh ini dapat mengalami nekrosis karena oksidan ini. Pemberian ekstrak etanol daun pegagan diharapkan dapat mencegah efek dari sodium nitrit. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak etanol daun pegagan terhadap gambaran histopatologi limpa tikus yang diinduksi dengan sodium nitrit subakut. Metode penelitian yang digunakan adalah penelitian eksperimental dengan posttest control group design. Sampel dibagi ke dalam 3 kelompok dengan 5 ekor tikus pada masing-masing kelompok. Kelompok tersebutadalah kelompok kontrol, PI (sodium nitrit 50 mg/kgBB), dan PII (sodium nitrit 50 mg/kgBB dan ekstrak etanol daun pegagan 600 mg/kgBB). Setelah perlakuan selama 42 hari, diambil preparat limpa tikus untuk dilihat rata-rata luas pulpa putih. Terdapat perbedaan tidak bermakna rata-rata luas pulpa putih pada setiap kelompok dengan rata-rata terkecilterdapat pada kelompok PI (p=0,899). Ekstrak etanol daun pegagan tidak berpengaruh secara bermakna terhadap gambaran histopatologi limpa yang diinduksi sodium nitrit subakut.Kata kunci: limpa, pegagan, pulpa putih, sodium nitrit
Pengaruh Suspensi Bubuk Kedelai Kuning terhadap Struktur Histologik Ginjal Tikus Diabetik Diinduksi Streptozotocin Fidianingsih, Ika
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2011)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v11i2.933

Abstract

Insidensi Diabetes Mellitus (DM) terus meningkat dan menjadi epidemik. DM merupakan faktor risiko terjadinya penyakit kardiovaskuler dan dapat menimbulkan kerusakan berbagai organ termasuk ginjal. Belakangan ini komponen bahan aktif kedelai kuning diduga berefek antikarsinogenik, antioksidan, antidiabetik, antilipidemik dan mencegah kerusakan sel ginjal. Tujuan penelitian ini adalah mengetahui efek kedelai kuning terhadap perbaikan struktur ginjal berdasar pengamatan histologi pada tikus DM diinjeksi streptozotocin. Tigapuluh ekor tikus wistar sehat, dibagi 5 kelompok. Kelompok 1 adalah kelompok kontrol, tikus tidak mendapat perlakuan, kelompok 2 adalah tikus diabetik, tanpa pemberian kedelai, kelompok 3, 4 dan 5 adalah kelompok tikus diabetik dan diberi suspensi bubuk kedelai kuning berturutturut 200, 400 dan 800 mg/kgBB tikus/hari selama 28 hari. Diabetes dinduksi streptozotocin 60mg/kg BB tikus.  Sampel jaringan ginjal dibuat preparat histologi dengan pewarnaan Hematoksilin-Eosin. Perbedaan tingkat kerusakan ginjal antar kelompok dianalisis One Way Anova. Hasil penelitian menunjukkan ratarata tingkat kerusakan ginjal kelompok tikus DM diberi kedelai 200, 400 dan 800mg/kgBB tikus/hari berturut-turut 2,87%±3,4; 1,68%±1,5; 1,80%±1,2; lebih sedikit dibanding tikus DM yang tidak diberi kedelai sebesar 6,35%±3,3. Terdapat perbedaan bermakna pemberian kedelai 400mg/kgBB/hari dengan kelompok tikus yang tidak diberi kedelai (p 0,05). Disimpulkan bahwa kedelai kuning dosis 400 mg/kg berat badan berpengaruh terhadap perbaikan kerusakan organ ginjal tikus diabetik.
Pengaruh Suspensi Bubuk Kedelai Kuning terhadap Struktur Histologik Ginjal Tikus Diabetik Diinduksi Streptozotocin Fidianingsih, Ika
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2011)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v11i2.933

Abstract

Insidensi Diabetes Mellitus (DM) terus meningkat dan menjadi epidemik. DM merupakan faktor risiko terjadinya penyakit kardiovaskuler dan dapat menimbulkan kerusakan berbagai organ termasuk ginjal. Belakangan ini komponen bahan aktif kedelai kuning diduga berefek antikarsinogenik, antioksidan, antidiabetik, antilipidemik dan mencegah kerusakan sel ginjal. Tujuan penelitian ini adalah mengetahui efek kedelai kuning terhadap perbaikan struktur ginjal berdasar pengamatan histologi pada tikus DM diinjeksi streptozotocin. Tigapuluh ekor tikus wistar sehat, dibagi 5 kelompok. Kelompok 1 adalah kelompok kontrol, tikus tidak mendapat perlakuan, kelompok 2 adalah tikus diabetik, tanpa pemberian kedelai, kelompok 3, 4 dan 5 adalah kelompok tikus diabetik dan diberi suspensi bubuk kedelai kuning berturutturut 200, 400 dan 800 mg/kgBB tikus/hari selama 28 hari. Diabetes dinduksi streptozotocin 60mg/kg BB tikus.  Sampel jaringan ginjal dibuat preparat histologi dengan pewarnaan Hematoksilin-Eosin. Perbedaan tingkat kerusakan ginjal antar kelompok dianalisis One Way Anova. Hasil penelitian menunjukkan ratarata tingkat kerusakan ginjal kelompok tikus DM diberi kedelai 200, 400 dan 800mg/kgBB tikus/hari berturut-turut 2,87%±3,4; 1,68%±1,5; 1,80%±1,2; lebih sedikit dibanding tikus DM yang tidak diberi kedelai sebesar 6,35%±3,3. Terdapat perbedaan bermakna pemberian kedelai 400mg/kgBB/hari dengan kelompok tikus yang tidak diberi kedelai (p0,05). Disimpulkan bahwa kedelai kuning dosis 400 mg/kg berat badan berpengaruh terhadap perbaikan kerusakan organ ginjal tikus diabetik.
SEL LEMAK DAN PERANANNYA DALAM PENYAKIT Ika Fidianingsih
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTIt is well know that adipose tissue mass increase greatly in obesity. In Indonesia obesityprevalence tends to increase. It raised the risk of morbidity and total cost attributable to obesityrelated disease. The adipose tissue is energy storage, fatty acids being released when fuel isrequired. It is now adipose tissue expresses and secretes factors with impotant endicrine functions.These factor include adiponectin, adipsin, leptin, protein of the renin-angiotensin system,plasminogen activator-1, other cytokines and resistin. A better understanding of the endocrinefunction of adipose tissue will give evidence of links between increased productios of someadipocyte factors and the metabolic and cardiovascular complications of obesity.Key words: adipose tissue, obesity, endocrine organ
Co-Authors Adeniar Yusnina Afiqoh, Ainun Nur Alissa Anna Safira Arif Reynaldi Alifiansyah Arjana, Adika Zhulhi Dadik Subiyanto Dewajani Purnomosari Dodi Faras Ilmiawan Sutomo Dwi Nur Ahsani Eddy Supriyadi Ety Sari Handayani Evy Sulistyoningrum Fuad Khadafianto Ghalib, Qoit Muhammad Abdul Ismaiyah Ismaiyah Izzati Muhimmah Kharisma, Muhammad Khoiriyah, Umatul Kusumawardani, Endah Najmuddin, Abdulhalim Ahmad Naufal Abdurrahman Nazarudin, Zohan Ninda Devita, Ninda Nurmasitoh, Titis Prasetyo, Mohamad Rizki Adi Raisha Amini Threeyana Ariyati Kadi Utami, Shindy Yudha Wijaya, Diani Puspa Yudha Prasetyo Utomo Zainuri Sabta Nugraha