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All Journal bionature As-syifaa Jurnal Farmasi
Rachmat Kosman, Rachmat
Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Uji Efek Anti-inflamasi Ekstrak n-Butanol dan Etil Asetat Daun Petai Cina (Leucaena leucocephala (Lamk.) De Wit) pada Mencit Jantan (Mus musculus) yang Diinduksi dengan Karagen Amirah, Sitti; Kosman, Rachmat; Novianti Y., Riany
bionature Vol 15, No 2 (2014): Oktober
Publisher : Fakultas MIPA UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.807 KB) | DOI: 10.35580/bionature.v15i2.1559

Abstract

Penelitian ini bertujuan untuk menentukan efek antiinflamasi dari ekstrak n-butanol dan etil asetat daun petai cina (Leucaena leucocephala (Lamk.) de Wit) berdasarkan penurunan volume radang pada telapak kaki mencit jantan. Penelitian ini menggunakan 24 ekor hewan uji dibagi menjadi 8 kelompok. Kelompok 1 sebagai kontrol negatif, kelompok 2 diberi suspensi natrium diklofenak sebagai pembanding, kelompok 3 diberi ekstrak etil asetat 0,5%, kelompok 4 diberi ekstrak etil asetat 1%, kelompok 5 diberi ekstrak etil asetat 1,5%, kelompok 6 diberi ekstrak n-butanol 0,5%, kelompok 7 diberi ekstrak n-butanol 1% dan kelompok 8 diberi ekstrak n-butanol 1,5%. Induksi dilakukan dengan menyuntikkan 0,05 ml karagen 1% b/v secara subkutan pada telapak kaki mencit. Setelah 1 jam setiap kelompok diberi sediaan uji peroral sebanyak 1 ml/30gBB. Pengukuran volume radang dilakukan pada menit 0, 30, 60, 90, dan 120. Hasil penelitian menunjukan bahwa ekstrak n-butanol dan etil asetat daun petai cina dapat menurunkan volume radang pada telapak kaki mencit. Ekstrak n-butanol memberikan efek antiinflamasi pada konsentrasi 0,5% sedangkan ekstrak etil asetat pada konsentrasi 0,5 % dan 1 % yang tidak berbeda bermakna terhadap natrium diklofenak.
Antibacterial Activity Assay Of Ethanolic Extract Of Bulbs Sticky Taro (Colocasia esculenta) Use TLC-Bioautografi Hibai, Achmad Rosyadi Yusuf; Herwin, Herwin; Kosman, Rachmat
Jurnal Ilmiah As-Syifaa Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.96 KB) | DOI: 10.33096/jifa.v7i1.24

Abstract

A research on antibacterial activity assay of sticky ethanolic extract from taro tuber (Colocasia esculenta) has been conducted in order to determine the antibacterial activity of ethanolic extract of the stem Colocasia esculenta against several assay bacteria use TLC-Bioautografi. Results of antibacterial activity screening showed that the ethanol extract of te Colocasia esculenta at a concentration of 1 mg/ml exhibited inhibitory activity against bacteria of Bacillus subtilis, Escherichia coli, Pseudomonas aerugginosa, Salmonella typhi, Shigella dysentriae, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, and Vibrio cholera. Test result showed by TLC-Bioautography using the eluent n-hexane : ethyl acetate (4:1) obtained Rf 0.38 value providing activity to Escherichia coli, Pseudomonas aerugginosa, Salmonella typhi, Shigella dysentriae, Staphylococcus aureus, Streptococcus mutans, and Vibrio cholera. The results of identification of active chemical component showed that the ethanolic extract of the stem of Colocasia esculenta on Rf 0.38 value was te alkaloid using dragendorf as the reagent.
IDENTIFIKASI PENGGUNAAN OBAT PADA PASIEN HIPERTENSI USIA LANJUT DENGAN BEER’S CRITERIA DI INSTALASI RAWAT INAP RUMAH SAKIT IBNU SINA MAKASSAR PERIODE TAHUN 2012 Sukmawati, Sukmawati; Kosman, Rachmat; Damayanti, Ira
Jurnal Ilmiah As-Syifaa Vol 8, No 1 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.255 KB) | DOI: 10.33096/jifa.v8i1.151

Abstract

Identification in the use medicine in geriatric patient of hypertension with Beer's Criteria In inpatient installation of Ibnu Sina Makassar hospital period 2012. In this study aims to observe and report on the use of drugs included in the Beers criteria on the use medicine in geriatrics patients of hypertension in the inpatient of Ibnu Sina Makassar Hospital. This is an observational study with the following descriptive design through the entire medical record in geriatrics patients who suffer from hypertension of Ibnu Sina Hospital in Makassar. The results showed that the types of drugs included in the Beers criteriaare nifedipine (3.44%), alprazolam (44.82%), lorazepam (13.79%), diazepam (13.79), estazolam (6.89 %), metokloperamide (10.34%), and mefenamic acid (3.44%).
UJI AKTIVITAS ANTIOKSIDAN KOMBINASI INFUSA BIJI ALPUKAT (Persea americana) DAN BIJI PEPAYA (Carica papaya L.) TERHADAP TIKUS PUTIH (Rattus norvegicus) DIABETES MELLITUS DENGAN PARAMETER MDA Rahman, Safriani; Kosman, Rachmat; Sudrianto, Sudrianto
Jurnal Ilmiah As-Syifaa Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.707 KB) | DOI: 10.33096/jifa.v7i1.23

Abstract

This research aims to determine the concentration Infusa Seeds Avocado and papaya seeds effective leaves that have antioxidant activity to MDA levels in diabetic mellitus with rats was induced with alloxan. This research used 21 white rats were divided into 7 groups. All rats were induced by alloxan 110 mg/KgBB intraperitoneally. Group I as a normal control,group II was administered with Na.CMC as a negative control, group III avocado seed infusion of 10%, group IV papaya seed infusion of 10%, group V infusion combination of avocado seeds and papaya seeds 4%v/v, group IV infusion combination of avocado seeds and papaya seeds 6%v/v, group VII infusion combination of avocado seeds and papaya seeds 8%v/v. Administration were given orally for 14 days orally. Before treatment, all groups except the group I was induced with alloxan 110 mg/kgBB in intraperitonially. Measurement of MDA levels before and after administration of infusion. MDA levels as measured on a spectrophotometer 532 nm wavelength. MDA Assay performed with TBA method. The results showed that the combined infusion of avocado seeds and papaya seeds, concentrations of 4%v/v, 6%v/v, 8%v/v effective as an antioxidant.
ISOLASI DAN IDENTIFIKASI GOLONGAN SENYAWA KIMIA FRAKSI DIETIL ETER DAUN BERUWAS LAUT (Scaevola taccada (Gaertn.) Roxb.) ASAL KABUPATEN PINRANG (SULAWESI SELATAN) Kosman, Rachmat; Tappang, Kurniati
Jurnal Ilmiah As-Syifaa Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.129 KB) | DOI: 10.33096/jifa.v4i2.87

Abstract

Isolation and identification of the chemical compound diethyl ether was done at beruwas laut leaves. Extraction is carried out using methanol and then partitioned with diethyl ether. Fraction of diethyl ether then isolated by column chromatography method using adsorben and n-hexane: ethyl acetate (3:7) as the elution fluid. Then obtained 30 fractions by color and by KLT profiles obtained 16 fractions. dominant fraction with patches further purified by preparative KLT to obtain the pure compound. Tape I at 366 nm UV rays were analyzed by ultraviolet-visible spectroscopy showed maximum absorption at a wavelength of 239.5 nm as measured from wavelength 200-800 nm. Whereas isolates infrared spectroscopic data allow hydroxy, aromatic, and alkyl ketones.Whereas chemical reactions showed positive flavanoid compounds.Key Words : Isolation and identification, fractions of diethyl ether, Scaevola taccada (Gaertn.) Roxb
ANALISIS KADAR PENGAWET NATRIUM BENZOAT PADA PRODUK MINUMAN BERKARBONASI DENGAN METODE HPLC Ismayani, Nur; Effendi, Nurmaya; Kosman, Rachmat; Rahmawati, Rahmawati
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.122 KB)

Abstract

It has been worked a research about the analysis of sodium benzoate content of carbonated beverages which is in Makassar market using High Performance Liquid Chromatography (HPLC) reverse phase. In this research, the analysis was conducted on four brands of carbonated beverages products. The results of analysis are sample A contains 47,6907 mg/kg, sample B 152,9348 mg/kg, sample C 271,4082 mg/kg, and sample D 357,3797 mg/kg of sodium benzoate. The four samples appropriate Permenkes No. 722/Menkes/Per/IX/1988 are <600 mg/kg.  Key words : Natrium Benzoate, HPLC, Carbonated Beverages
UJI AKTIVITAS ANTIOKSIDAN TERONG BELANDA (SOLANUM BETACEUM CAV.) DENGAN METODE FRAP Inayah, Nurul; Kosman, Rachmat; Syarif, Sukmawati
Jurnal Ilmiah As-Syifaa Vol 7, No 1 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.428 KB)

Abstract

Test Antioxidant Activity of Dutch eggplant (Solanum betaceum Cav.) with FRAP method. This study aims to measure and determine the antioxidant activity Dutch eggplant (Solanum betceum Cav.) with FRAP method. Dutch eggplant was analyzed qualitatively by using the metod FRAP with FRAP reagent. Quantitatively mix with the sample solution was analyzed by FRAP method Uv-Vis spectrophotometer at a wavelength 596 nm. By using trolox as a reference standard. The results obtained in this research that Dutch eggplant has antioxidant activity with an total value of antioxidant activity, 0,9353 µmol Trolox/gr sample.
TOXICITY TEST DIETHYL ETHER EKSTRACT OXALIS CORNICULATA L. HERB ON BRINE SHRIMP LETHALITY TEST METHOD Kosman, Rachmat; Baits, Muzakkir; Herwin, Herwin
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.895 KB)

Abstract

Recearch toxicity effect of  standar dietil eter ekstract Oxalis corniculata L. herb at Artemia salina Leach with purpose  to determine toxicity potencial and LC50 value Oxalis corniculata L. herb on  brine shrimp lethality test method. The result of this research shows that diethyl ether ekstract Oxalis corniculata L. herb at concentration  100, 50, 5, 1, 0.5, 0.1, 0.05, 0.01 µg/ml and controler is diethyl ether. Presentation data of Artemia salina Leach larvae was analyzed with probit analysis to count LC50. Ekstract is toxic if LC50 value < 1000 µg/ml. So obtained that diethyl ether ekstrak Oxalis corniculata L. herb is toxit to Artemia salina Leach larvae with LC50 4,17± 2,59 µg/ml. Key words : Oxalis corniculata L, Toxicity, Brine Shrimp Lethality Test.
UJI EFEK HIPOLIPIDEMIK EKSTRAK ETANOL KAYU SECANG (Caesalpinia sappan L.) TERHADAP TIKUS WISTAR (Rattus norvegicus) JANTAN Rahman, Safriani; Kosman, Rachmat; Wijaya, Ika Indra
Jurnal Ilmiah As-Syifaa Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.916 KB) | DOI: 10.33096/jifa.v7i2.1

Abstract

Sappan wood contains brazilin compounds that acts as antioxidants to inhibit the cholesterol synthesis, so it is efficacious hypolipidemic. It has been conducted the research on hypolipidemic effect assay of ethanol extract of sappan wood against male wistar rats. This research aims to determine the hypolipidemic effect from the ethanol extract of sappan wood based on a decrease in cholesterol content of rats. This research used 15 male rats were divided into 5 groups. Group I (control) was given suspension Na. CMC 1%, group II (comparator) was given simvastatin, the groups III, IV, and V were given ethanol extract of sappan wood at a dose 75 mg/kgbw, 150 mg/kgbw, and 300 mg/kgbw. All provisions were done orally once a day for 14 days. Cholesterol content measurements were done at the beginning of cholesterol before induction, after induction and after treatment. Before treatment rats were induced with propylthiouracil 0.01% and high cholesterol diet. The results showed that the ethanol extract of the sappan wood has a hypolipidemic effect and a dose 300 mg/kgbw was not significantly different (p > 0.05) with simvastatin.
PRODUKSI DAN ANALISIS AGAROSA DARI RUMPUT LAUT JENIS Gracilaria sp. ASAL KABUPETEN TAKALAR Abidin, Zainal; AP, Pirman; Kosman, Rachmat
Jurnal Ilmiah As-Syifaa Vol 2, No 1 (2010): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v2i1.103

Abstract

Has been done attempt production and analisis of agarose from seaweed Gracilaria sp. of Takalar Regency, with aim to produce agarose and analysis physicochemical properties such as viscosity, yield value, and characterized fungsional groups of agarose with Spectra Infra Red (IR). The result attempt showed that 10 gram of seaweed Gracilaria sp. yield 1,434 gram agarose, and if agarose in colloid solution 1% at 80oC had the viscosity 15,2 cP and the yield value 0,039 dyne cm-, while IR spectra obtained the hydroxyl group (OH) with hydrogen bonding in the region 3455.10 cm-1, the hydrocarbon group (C-H) in the region 1455.77 cm-1 and the  ethers group (C-O) in the region 1077.32 cm-1. Which the result could be compared with the standart agarose.  Key words :  Agarose, Glacilaria Sp., Takalar
Co-Authors Achmad Rosyadi Yusuf Hibai, Achmad Rosyadi Yusuf Andi Maulana Kamri Bayu Putra, Bayu Herwin Herwin, Herwin Ika Indra Wijaya, Ika Indra Ira Damayanti, Ira Kurniati Tappang, Kurniati Melinda, Pina Muzakkir Baits, Muzakkir Nur Ismayani, Nur Nurmaya Effendi Nurul Inayah Pirman AP, Pirman R. Rusli Rahmawati, Rahmawati Riany Novianti Y., Riany Safriani Rahman, Safriani Sitti Amirah, Sitti Sudrianto Sudrianto, Sudrianto Sukmawati Sukmawati Sukmawati Syarif, Sukmawati Zainal Abidin