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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease
Netty Sukmawati, Netty
Dept. Of Dermatology, School of Medicine, Universitas Airlangga, Surabaya
Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Mycobacterium leprae BACILLEMIA IN BOTH TWINS, BUT ONLY MANIFEST AS LEPROSY IN ONE SIBLING Sukmawati, Netty; Agusni, Indropo; Listiawan, M. Yulianto; Prakoeswa, Cita Rosita S.; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 7 (2015)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v5i7.1206

Abstract

Leprosy in twins is rarely reported. A 19 years-old male student, from Lamongan district, was diagnosed as Multibacillary (MB) leprosy in the Skin and STD Clinic of Dr. Soetomo General Hospital Surabaya. Multiple anesthetic skin lesions were found, but the bacteriologic examination was negative for Acid Fast Bacilli (AFB). Histopathology examination support the diagnosis of BL type of leprosy. His twin brother that has been lived together since born until present seems healthy without any complaints of skin lesions and have no signs of leprosy. When a serologic examination for leprosy was performed, a high anti PGL-1 antibody level was found in patient (IgM anti PGL-1 2937 and IgG anti PGL-1 3080 unit/ml) while his healthy twin brother showed only low level (IgM 745 and IgG 0 unit/ml). Interestingly when a PCR study was performed to detect M.leprae in the blood, both of them showed positive results. Using the TTC method, a genomic study of for M.leprae, it is revealed that both samples were identic ( 27x TTC repeats). According to patient’s history, he had a traffic accident and got a wound in the knee seven years ago, while the skin lesions seems started from this area around three years ago before it spread to other parts of the body. The patient was treated with Multi-drug therapy (MDT) while his sibling got a prophylactic treatment for leprosy. After 6 months of treatment, the leprosy skin lesions were diminished and the serologic anti PGL-1 has been decreased. His healthy brother also showed a decrease in anti PGL-1 level and no skin signs of leprosy.
Characteristic of Subcutan Mycosis: A Retrospective study Sukmawati, Netty; Ervianty, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.335 KB) | DOI: 10.20473/bikkk.V27.3.2015.183-190

Abstract

Background: Subcutaneous mycosis is a rare cases. Incidence of subcutaneous mycosis in Indonesia is unknown. Limited experiences, problems in diagnosis and management may cause difficulties in treating subcutaneous mycosis. Objective: To know the characteristic of subcutaneous mycosis cases in Indonesia and to improve the quality of medical service. Methods: Retrospective study of cases were treated in Departement of Dermatology and Venereology Dr. Soetomo General Hospital within 2010–2014 (5 years). The data include number of cases, age, sex, domicile, complained, risk factors, duration of illness, location of skin lesion, symptoms, laboratory examination, and treatment. Results: a number of cases ranged between 1-8 patients per year. There was 1 case in 2010, 2 cases in 2011, 2 cases in 2012, 2 cases in 2013, and 8 cases in 2014. The diagnosis included eumycetoma, actinomycetoma, chromoblastomycosis, basidiobolomycosis, and phaeohyphomycosis. No cases of sporotrichosis, lobomycosis, and rhinosporodiosis. Majority of patients showed specific characteristic history, clinical manifestation, and histopathology examination, but most culture results were negative. Treatment was given based on diagnosis. Conclusions: Number of subcutaneous mycosis cases per year is 1-8 patients. Diagnosis based on characteristic history, clinical manifestations and histopathology examination.Key words: mycosis subcutan, characteristic, retrospective study.
Co-Authors CITA ROSITA S. PRAKOESWA DINAR ADRIATY Evy Ervianty, Evy INDROPO AGUSNI ISWAHYUDI ISWAHYUDI M. Yulianto Listiawan RATNA WAHYUNI