Ryski Meilia Novarina, Ryski Meilia
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The Profile of Erysipelas and Cellulitis Patients Novarina, Ryski Meilia; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.74 KB) | DOI: 10.20473/bikkk.V27.1.2015.32-40

Abstract

Background: Erysipelas and cellulitis are acute infectious serious skin diseases, due to the entry of bacteria through the unintact skin barrier and can be fatal. Purpose: To determine the clinical manifestation and management of hospitalized erysipelas and cellulitis patients at the dermatolovenerology inpatient Dr. Soetomo General Hospital in period of 2008-2011. Methods: The study was conducted retrospectively based on the medical records of the hospitalized patients include case number, gender, age, main complaint and duration, trigger factors, concomitant factors that can be as the underlying disease, lesion site, laboratory examinations, treatments, length of treatment associated with Erythrocyte Sedimentation Rate (ESR) and the prognosis. Results: The erysipelas and cellulitis cases were 65 cases (1.9%) of the total hospitalized cases of skin diseases, with the number of men and women were 36 and 29 patient, respectively. The highest age group were 45-65 years (35.4%). Main complaint was swelling, redness and pain (66,2%) and the duration of complaints 1-7 days (81.5%), Most triggering factors due to scratching (34%). Anemia (30,8%) is the most underlying disease. The majority of lesion sites are in the lower extremities in 56 patients (86.1%). Laboratory tests showed anemic (30.8%), leukocytosis (44.6%) and (76.9%) ESR > 20mm/h (76.9%). The specimen of the lesion of 18 cases were cultured, there were found majority bacterial were Staphylococcus aureus (37.5%). The managements of treatment of 25 cases (38.5%) were consisted: immobilization, intravenous injection of Ampicillin and wet dressing with normal saline, 15 cases with ESR>50mm/h were treated for 8 -14days. The complications (gangrenosum cellulitis) were found in 1 case (1,5%), and 40 patients (61.5%) discharge from hospital in a recovery state. Conclusion: The management of patients with erysipelas and cellulitis had been appropriate based on the diagnosis and treatment guidelines. Staphylococcus aureus is the most frequent bacteria found in culture.Key words: erysipelas, cellulitis, Staphylococcus aureus.
Pemeriksaan Imunohistokimia untuk Mengungkap Patogenesis Vitiligo Sandhika, Willy; Novarina, Ryski Meilia; Setyaningrum, Trisniartami
Cermin Dunia Kedokteran Vol 43, No 10 (2016): Anti-aging
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v43i10.872

Abstract

Vitiligo merupakan penyakit kulit yang ditandai dengan area putih yang makin luas. Patogenesis penyakit vitiligo melibatkan berbagai etiologi yang saling berkaitan seperti genetik, autoimun dan inflamasi. Pemeriksaan imunohistokimia pada bahan biopsi kulit penderita vitiligo meliputi pemeriksaan antibodi CD3, CD8, TNF-α, IL-17 dan IL-17RA, CD117, NALP1, Langerin serta CD11c dapat mengungkap patogenesis penyakit sehingga dapat membuka jalan untuk terapi yang sesuai.Vitiligo is a skin disorder characterized by progressive white macules. The pathogenesis involves various interrelated etiologies such as genetic, autoimmune and inflammation. Immunohistochemical examination on skin biopsy using antibody CD3, CD8, TNF-α, IL-17 and IL-17RA, CD117, NALP1, Langerin and CD11c may reveal the pathogenesis of the disease to facilitate appropriate therapy.