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All Journal International Journal of Integrated Health Sciences Althea Medical Journal MNJ (Malang Neurology Journal) Cermin Dunia Kedokteran
Uni Gamayani, Uni
Unknown Affiliation
Health Professions Medicine & Pharmacology Neuroscience Public Health

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Undernutrition as Risk Factor of Hydrocephalus Prevalence in Children with Tuberculous Meningitis Sinaga, John Patria Maruli; Risan, Nelly Amalia; Gamayani, Uni
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.901 KB)

Abstract

Background: Hydrocephalus is the most frequent neurological complication in children with tuberculous meningitis. Tuberculosis infection cannot be separated from nutritional status. Children with undernutrition have decreased immunity thus could affect clinical manifestation of tuberculous meningitis. This study was conducted to identify the relationship between undernutrition and the prevalence of hydrocephalus in tuberculous meningitis.Methods: An analytic observational study was carried out to 38 medical records of children with tuberculous meningitis in Dr. Hasan Sadikin General Hospital from 2007 to 2015. Variables that were studied included gender, age, advanced stage of disease, motoric paralysis, history of seizure, nutritional status and hydrocephalus. The collected data were analyzed using Chi-Square test. Results: Out of 21 subjects with undernutrition, 11 subjects were found to have hydrocephalus. The analysis using chi-square was statistically significant (p=0.009). Prevalence ratio=4.45 (CI 95% 1.14−45.43), meaning tuberculous meningitis children with undernutrition were at risk of hydrocephalus 4.45 times greater than children with normal nutritional status.Conclusions: Undernutrition may increase the risk of hydrocephalus in children with tuberculous meningitis. [AMJ.2017;4(1):143–7] DOI: 10.15850/amj.v4n1.1036
Relationship between C677T Methylenetetrahydrofolate Reductase Gene Polymorphism and Homocysteine in Cerebral Palsy Gamayani, Uni; Machfoed, M. Hasan; Idjradinata, Ponpon; Achmad, Tri Hanggono
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : International Journal of Integrated Health Sciences

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Objective: To observe the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and homocysteine levels in cerebral palsy (CP) children. Methods: This cross-sectional study was conducted in several hospitals, school for children with special needs, and rehabilitation centers in Bandung from March to November 2014, on children with CP aged 4–14 years who met the inclusion criteria. Genotyping was performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and direct sequencing. Homocysteine serum level was measured using chemiluminescent microparticle immunoassay (CMIA) method. Statistical analysis was conducted using t test. Results: In this study, 150 CP children had MTHFR C677T gene polymorphism with a frequency of 18%, consisting of TT homozygotes (4%), CT heterozygotes (14%), and T allele (11%. The mean serum level of homocysteine in CP with C677T MTHFR gene polymorphism was 8.22 (±1.89) µmol/L, higher than those without polymorphism (p=0.046). Conclusions: A relationship between MTHFR C677T gene polymorphism and homocysteine level in children with cerebral palsy is found in this study. Keywords: Cerebral palsy, homocysteine, methylenetetrahydrofolate reductase polymorphism DOI: 10.15850/ijihs.v4n1.682
COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA Wardoyo, Chandra Calista; Gamayani, Uni; Ong, Anam; Rizal, Ahmad; Wibisono, Yusuf; Amalia, Lisda; Panigoro, Ramdan
Malang Neurology Journal Vol 7, No 1 (2021): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.6

Abstract

Background: Cognitive impairment in thalassemia patients are prevalent, therefore early detection of cognitive impairment in adult thalassemia patients is crucial for prevention. Montreal Cognitive Assessment (MoCA) is a public domain cognition screening tools that covers all cognitive domains in detecting mild cognitive impairments.Objective: To compare cognitive function between adult thalassemia patients and healty control by using Indonesia version of MoCA test (MoCA-Ina)Methods: This prospective observational analytic with case control study, compared the total scores and scores of each domain of cognition between adult thalassemia patients and healthy subjects at the Medical Hematology Oncology Clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia using MoCA-Ina from August to October 2018.Results: A total of 32 thalassemia subjects and 50 healthy subjects were conducted. A total of 16(50%) subjects in the case group had a value of MoCA-Ina <26, while only 1(2%) healthy control had a value of MoCA-Ina <26. The median total MoCA-Ina score in case and control groups were 25.5 and 27.50 (p <0.001). The median score of memory domains, executive functions and visuospatial of the case and control groups were 3 versus 4 (p <0.001), 3 versus 3.5 (p <0.001) and 3.53 ± 0.671 versus 3.88 ± 0.385 (p <0.003), respectively.Conclusion: Adults thalassemia patients have lower score in total MoCA-Ina, domains of memory, executive function and visuospatial score compared to healthy control.
Incidence of Peripheral Neuropathy in Major Beta-Thalassemia Patients at Hasan Sadikin General Hospital, Bandung, Indonesia Putri, Fanny Adhy; Gamayani, Uni; Lailiyya, Nushrotul; Panigoro, Ramdan
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (610.493 KB) | DOI: 10.55175/cdk.v46i9.416

Abstract

Bakground. Beta major thalassemia is the most common inherited blood disorder worldwide. It can lead to various neurological complications such as peripheral neuropathy. Toronto Clinical Neuropathy Score (TCNS) is helpful for peripheral neuropathy screening especially in diabetes mellitus. Objective. To investigate the prevalence of peripheral neuropathy in beta major thalassemia patient using Toronto Clinical Neuropathy Score (TCNS). Method. A descriptive study on beta major thalassemia patients aged more than 14 years who regularly underwent blood transfusions in Hasan Sadikin General Hospital Bandung, from July to August 2017. Normal TCNS values was < 4, mild neuropathy 5-7, moderate neuropathy 8-10 and severe neuropathy > 10. Results. Sixty subjects met the inclusion criteria, 48,3% were male with the mean (SD) age of 20,7 ± 7,6 years. Mean hemoglobin value was 6,7 ± 0,9 g/dL and median (IQR) blood ferritin serum was 2873 (1900-3859) μg/L. Thirty-two subjects had neuropathy; 19 (31,7%) with mild neuropathy and 13 (21,6%) with moderate neuropathy.Conclusion. The incidence of peripheral neuropathy in patients with thalassemia according to TCNS score is fairly high.Latar Belakang. Talasemia beta mayor adalah kelainan darah bawaan paling umum di dunia dan dapat menyebabkan berbagai komplikasi, salah satunya neuropati perifer. Toronto Clinical Neuropathy Score (TCNS) dapat digunakan untuk penilaian neuropati perifer yang disebabkan oleh berbagai penyakit sistemik. Objektif. Menyelidiki prevalensi neuropati perifer pada pasien talasemia beta mayor menggunakan Toronto Clinical Neuropathy Score (TCNS). Metode. Penelitian ini studi deskriptif skrining menggunakan TCNS pada pasien thalassaemia beta mayor berusia lebih dari 14 tahun yang secara teratur menjalani transfusi darah di Rumah Sakit Umum Hasan Sadikin Bandung, dari Juli hingga Agustus 2017. Nilai TCNS normal adalah <4, neuropati ringan 5-7, neuropati sedang 8-10 dan neuropati berat> 10. Hasil. Sebanyak 60 subjek memenuhi kriteria inklusi, 48,3% laki-laki dengan usia rata-rata (SD) 20,7 ± 7,6 tahun. Nilai hemoglobin rata-rata 6,7 ± 0,9 g / dL dan serum ferritin darah median (IQR) adalah 2873 (1900-3859) μg / L. Tiga puluh dua subjek memiliki neuropati; 19 (31,7%) neuropati ringan dan 13 (21,6%) neuropati sedang. Simpulan. Insiden neuropati perifer pada pasien dengan talasemia menurut skor TCNS cukup tinggi.
Co-Authors ahmad rizal Anam Ong Lailiyya, Nushrotul Lisda Amalia M. Hasan Machfoed, M. Hasan Nelly Amalia Risan, Nelly Amalia Ponpon Idjradinata Putri, Fanny Adhy Ramdan Panigoro Sinaga, John Patria Maruli Tri Hanggono Achmad Wardoyo, Chandra Calista Yusuf Wibisono