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All Journal Berkala Kedokteran Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Ferry Armanza, Ferry
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PERBANDINGAN TINGKAT REPRESENTATIF PEMERIKSAAN PAP SMEAR METODE KOMBINASI SPATULA AYRE–CYTOBRUSH DENGAN METODE CERVEX BRUSH Kusumawati, Erika; Rahardja, Suka Dwi; Armanza, Ferry
Jurnal Berkala Kedokteran Vol 10, No 1 (2014): Februari 2014
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.395

Abstract

ABSTRACT: One way of early detection for cervix cancer is the Pap smear. This study aim is to compare the level of representative Pap smear method using combiation Ayre spatula-cytobrush with cervex brush method. This study is a descriptive analytic study with cross sectional approach. 47 pieces of preparat were selected according to inclusion criteria over the period of January-September 2013. Representative results of Pap smear using the combination of Ayre spatula-cytobrush and the used of brush cervex were 36 (76.60%) and 40 (85.10%). The results of data analysis using the Wilcoxon test with 95% confidence level indicates no statistically significant difference between the use of a combination of Ayre spatula-cytobrush methods with cervex brush method, the value of p = 0.157 (p> 0.05). It can be concluded that the representative rate of Pap smear using a combination of Ayre spatula-cytobrush method is not better than cervex brush method. Keywords: Pap smear, ayre spatula, cytobrush, cervex brush  ABSTRAK: Salah satu cara deteksi dini kanker servik adalah pemeriksaan Pap smear. Penelitian ini bertujuan untuk membandingkan tingkat representatif pemeriksaan Pap smear metode kombinasi spatula ayre-cytobrush dengan metode cervex brush. Penelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross sectional. Preparat penelitian sebanyak 47 buah dipilih sesuai kriteria inklusi pada periode bulan Januari – September 2013. Hasil representatif Pap smear menggunakan kombinasi spatula ayre-cytobrush yakni 36 (76,60%) dan yang menggunakan cervex brush sebanyak 40 (85,10%). Hasil analisis data menggunakan uji wilcoxon dengan tingkat kepercayaan 95% , didapatkan hasil bahwa tidak terdapat perbedaan yang bermakna secara statistik antara penggunaan metode kombinasi spatula ayre-cytobrush dengan metode cervex brush yaitu dengan nilai  p = 0,157 (p > 0,05). Dapat disimpulkan bahwa tingkat representatif pemeriksaan Pap smear menggunakan metode kombinasi spatula ayre-cytobrush tidak lebih baik dibandingkan metode cervex brush. Kata-kata kunci: Pap smear, spatula ayre, cytobrush, cervex brush
Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.533 KB)

Abstract

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%. [Indones J Obstet Gynecol 2014; 2-1: 40-45] Keywords: cervical cancer, SCC, therapeutic response, VEGF
Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry; Andrijono, Andrijono; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.533 KB) | DOI: 10.32771/inajog.v2i1.378

Abstract

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%.  Keywords: cervical cancer, SCC, therapeutic response, VEGF
Co-Authors Andrijono Andrijono Bambang Sutrisna Erika Kusumawati Suka Dwi Rahardja, Suka Dwi