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All Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional Detector: Jurnal Inovasi Riset Ilmu Kesehatan JURNAL FARMASI DAN KESEHATAN INDONESIA Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi

Tatiana Siska Wardani

Universitas Duta Bangsa Surakarta

Author-ID : 5831589

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Literature Review: Antioxidant Test of Basil Leaves (Ocimum Sanctum) Noka Riyani; Kusumaningtyas Siwi Artini; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Basil leaves is family of lamiaceace, which is known as daun kemangi (Indonesia). This plant is widely use as a herb. Indonesian also used basil leaves as a seasoning in their food. It has chemical compound such as flavonoid so it has an antioxidant effect. The aim of this reseach is to find out the antioxidant effect of the basil leaves, the chemical compound of basil leaves. The method by reviewing online articles at Pubmed, sciencedirect and Google Scholar. Cemichal compound wes identified in some reseach. It show different potential base on the extraction proses. The antioxidant effect was tested using the DPPH method for determination of IC50. By reviewing articles, we can conclude that basil leaves have an antioxidant effect.

Literature Review: The Potencial Effect of Dandang Gendis Leave (Clinacanthus nutans Lindau) Kusumaningtyas Siwi Artini; Weri Veranita; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Indonesian are used to use herb to medicate a disease. One of the medicinal plants used is Clinacnathus nutans (Burm.f.) Lindau. Clinacnathus nutans Lindau is a traditional plant, commonly known as dandang gendhis (Java – Indonesia), ki tajam (Sunda – Indonesia), belalai gajah (Malaysia), Sabah Snake Grass (Singapore), and phaya yo (Thailand). It belonging to the Acanthaceae family. This study aimed to find out the the effect of giving the extract of Clinacnathus nutans Lindau to subject. This research method was using literature review. The information about Clinacanthus nutans Lindau collected from an online database such as Pub Med, Scient direct and Google Scholar. The number of chemical compound were identified from leaves. It contain of alkaloid, flavonoid, polifenol, saponin and tanin Some of the potential effect shown such as antihypoglycemic, antioxidant and anticancer, and analgetic. In this study,we can conclude that in the future Clinacnathus nutans Lindau is valuable to use as herbal medicine with more investigation.

Increased Levels of Fermented Soy Milk Amino Acids And Effectivenes Helping Reduce Uric Acid Serum In Male White Rats Danang Raharjo; Veranita Weri; Wardani tatiana siska
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Soybean is one of the most important foodstuffs for the people of Indonesia, which is consumed to meet the nutritional needs of protein. Soybeans are consumed by the public as a side dish and snack. Soy milk is a form of processed soybean. Previous research has shown that tempeh, which is a form of fermented soybean, can reduce purine levels in soybeans, and can increase nutritional value, especially amino acid content. The purpose of this study was to determine the increase in amino acid content of fermented soy milk with the help of Lactobacilus Kasei bacteria, and its effect in helping to reduce serum uric acid levels in the blood of male white rats. Fermented soy milk is made of 250 grams of soybeans and squeezed in 5 liters of water, then heated. Lactobacilus kasei is used as a battery for fermentation and 500 grams of palm sugar is used as a source of nutrition for bacteria. The test to reduce uric acid levels was carried out in vivo by giving male white rats drinking as much as 10 mL, 20 mL, 30 mL, 40 mL, 50 mL for 14 days, then taking the blood through the tail vein, then measuring the uric acid levels using the strip method. test with the GCU easy tooch tool. To increase uric acid levels in male white rats was done by induction with chicken's liver. The results of measuring the levels of amino acids in the fermentation of soy milk increased between 1-2% with the following levels: Lysine 4.7%, Histidine 2.3%, Arginine 4.9%, Asparkate 7.8%, Treonine 2.9%, Serine 2.9%, Glutamate 14.2% , Proline 3.8%, Glycine 3.7%, Alanine 2.8%, Cystine 1.6%, Valine 3.2%, Methionine 1.2%, Isoleucine 3.8%, Leucine 5.9%, Tyrosine 2.7% , Phenylalanine 3.3%. Testing of uric acid levels in the blood of male white rats after fermented soy milk with various volume series were as follows: 6.70 mg/dL ± 1.16; 5.88 mg/dL ± 0.81; 4.63 mg/dL ± 0.92; 4.18 mg/dL ± 0.71; 4.16 mg/dL ± 0.96. Based on the results of the study, it can be concluded that fermented soy milk with the help of lactobacillus kasei bacteria can increase amino acid levels ranging from 1-2%, and the provision of drinking fermented milk can help reduce blood uric acid levels in male white rats with blood uric acid levels by 4.16 mg/dL ± 0.96.

Antioxidant peel off mask formulation of tamarind seeds ethanol extract Putri Djatmiko Marchia Afifah; Veranita Weri; Wardani Siska Tatiana
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

The human body does not have excess reserves of antioxidants, so if a lot of radicals are formed, the body needs exogenous antioxidants. In an effort to get healthy skin we also must not forget about antioxidants to protect our skin. The adequacy of antioxidants is a bulwark to prevent the harmful effects of free radicals that damage the skin. But there are concerns about the possible side effects that have not been known from synthetic antioxidants, causing natural antioxidants to become a much needed alternative, one of which comes from plants. One plant that has antioxidant properties is tamarind seeds. Tamarindus indica L seeds contain polyphenol compounds and high antioxidant potential. The methanol extract of tamarind seeds has a higher content of polyphenol compounds and antioxidant potential than the methanol extract of other parts of the Tamarindus indica plant. Based on antioxidant research, the ethanol extract of tamarind seeds has an IC50 value of 40.21 ± 4.07262. The purpose of this study was to formulate an antioxidant peel off mask from tamarind seed extract using ethanol solvent with the maceration method. Furthermore, the extract obtained was formulated into a peel off preparation using 3 formulas with 5%, 10%, and 15% concentrations, respectively. The preparation is then tested for the evaluation of organoleptic preparations, homogeneity, pH, viscosity and flow properties, dispersibility, drying time, stability test, and irritation test

Existence Test Of Escherichia Coli and Pseudomonas Aeruginosa Bacteria in Packaging Drinking Water in Cemani Village, Sukoharjo Regency Nuraini Putri Rahmawati; Wardani Siska Tatiana; Veranita Weri
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Clean, potable fresh water is becoming scarce in cities, the river which is the source of it is polluted with various wastes ranging from organic waste, household waste, to industrial waste. The quality of drinking water also affects public health, especially bottled drinking water. One of the parameters for the quality requirements of bottled drinking water is the test for Escherechia coli and Pseudomonas aeruginosa bacteria. The purpose of this study was to identify the contamination of Escherechia coli and Pseudomonas aeruginosa bacteria in bottled drinking water samples, using the MPN (Most Probable Number) method. The research method uses descriptive research. The research population of bottled drinking water in stalls around the Duta Bangsa University Surakarta campus is as many as 7 samples. Collecting data by laboratory observation, data analysis with descriptive analysis. The results of the study were carried out from seven samples of bottled drinking water, all samples were not detected by the Escherechia coli and Pseudomonas aeruginosa bacteria. The conclusion of this study is that there are no Escherechia coli and Pseudomonas aeruginosa bacteria in bottled drinking water sold in stalls around the campus of Universitas Duta Bangsa Surakarta.

Literature Study of Three Plant Formulations with Anti-Candida Albicans Activity in Feminine Liquid Soap Preparations Tatiana Siska Wardani; Kusumaningtyas Siwi Artini; Ilham Latansa
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Candida albicans is a fungus that causes vaginal discharge in women. Leucorrhoea is a discharge from the vagina with a relatively small frequency, odorless, and clear. In Indonesia, there are many plants that have medicinal properties that are used in traditional medicine and are believed to have antifungal activities.Feminine hygiene soap is a liquid cleansing preparation for femininity which is made from basic ingredients and is used to clean the feminine area without causing irritation to the skin.This study aims to provide information about plants that have anti-fungal activity and their formulation as a good female liquid soap preparation with their activity as an anti-candida albicans. The method in this research is by searching literature studies from various journals. The results showed that each female liquid soap preparation with plants as the active substance gave different inhibition diameters. The difference between the active substance and the additive in the formulation affects the resulting inhibition diameter. Based on the results of a literature review, basil,cabbage (Brassica oleracea var. capitata alba) and waru (Hibiscus tiliaceus), has activity as an antifungal against Candida albicans.

Tests for the antibacterial and anti-inflammatory potential of the Asem Tengger plant (Radicula armoracia Robinson) obtained from the ethnomedicine study in the Tengger tribe Yaya Sulthon Aziz; Rony Setianto; Tatiana Siska Wardani; Nurul Nurhayati; Belinda Arbitya Dewi
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Purpose: Local wisdom, especially in the Tengger Bromo tribe, East Java makes a potential that must be developed sustainably. The Asem Tengger plant (Radicula armoracia Robinson) is a plant that has antibacterial and anti-inflammatory potential in the Tengger tribe. This plant has high ICF and UV values. This study aims to determine the types of plants that have been used by the Tengger Tribe have antibacterial and anti-inflammatory activities with the dilution method and in vitro cell membrane stability. Methodology: Samples were taken from the Tengger Bromo Probolinggo Tribe, extracted by maceration using 95% ethanol. Characterization includes non-specific parameters and specific parameters. Identification of chemical contents includes flavonoids, glycosides, saponins, alkaloids. Antimicrobial test by dilution method, each concentration was tested on Staphylococcus aureus ATCC 2592, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 27853, Salmonella typhi ATCC 13311, and Candida albicans ATCC 10231. The anti-inflammatory activity test using ethanol extract from muscle flour was made up to a concentration of 250 ppm, 500 ppm, 1000 ppm, and 2000 ppm with the in vitro anti-inflammatory test with the human red blood cell (HRBC) method. Results: Based on the antimicrobial test, Asem Tengger has the potential to be antibacterial to Staphylococcus aureus ATCC 2592 in the water and n-hexane fractions with a value of 2.5% MBC. The anti-inflammatory test showed the results of membrane stability of 57.97% from a concentration of 2000 ppm which shows a number that has the potential to be a reference for potential medicinal plants. Value: The Asem Tengger plant used by the Tengger tribe has the potential as new antimicrobials and anti-inflammatory

Ethanol Extract Guava Leaves (Psidium Guajava) Give Antidiabetic Effect On Male Mice With Alloxan Induction Tiara Ajeng Listyani; Aisyah Rabitha Alisi; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology Proceeding of the 3rd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Diabetes mellitus is a chronic condition caused by increasing glucose level in blood. Long term use of antidiabetic drugs can cause various unwanted side effects, which makes people with diabetes try to use natural materials to control blood glucose levels. The aim of this study was to determine the antidiabetic activity of ethanol extract guava leaves (Psidium guajava) on male mice with alloxan induction. Mice were induced intravenously by alloxan dose of 160 mg/kg bw. After 7 days, mice were diabetic (blood glucose levels > 175 mg/dL) and were divided into 5 groups: negative control group (only treated with CMC-Na) ,positive control group (glibenclamide 0.65 mg/kg bw) and the 3 other groups were given ethanol extract guava leaves (Psidium guajava) at doses of 150 ,300 and 600 mg/kg bw. Dosage administered for 15 days and blood glucose levels was checked every 3 days using a glucotest. Data were analyzed by LSD (Least Significant Difference). Ethanol extract guava leaves (Psidium guajava) at doses of 150 ,300 and 600 mg/kg bw can lower blood sugar levels from day 3 to day 15 and was significantly different compared to the negative control group (p<0,05). Ethanol extract guava leaves (Psidium guajava) at doses of 150 ,300 and 600 mg/kg bw showed antidiabetic activity on male mice with alloxan induction.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI N-HEKSAN, FRAKSI ETIL ASETAT, FRAKSI AIR DARI DAUN UBI JALAR UNGU (Ipomoea batatas L.) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 Weri veranita; dewi mei ika widiyastuti; Tatiana siska wardani
Prosiding Seminar Informasi Kesehatan Nasional 2021: SIKesNas 2021
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Daun ubi jalar ungu (Ipomoea batatas L.) mengandung flavonoid, saponin dan tannin. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol, fraksi n-heksan, fraksi etil asetat, fraksi air dari daun ubi jalar ungu terhadap pertumbuhan bakteri Staphylococcus aureus ATCC 25923. Daun ubi jalar ungu diekstrak secara maserasi dengan menggunakan pelarut etanol 96%, kemudian difraksinasi dengan menggunakan pelarut n-heksan, etil asetat, dan air. Ekstrak etanol 96%, fraksi n-heksan, etil asetat dan air diuji aktivitas antibakteri dengan menggunakan metode difusi dengan konsentrasi 1%, 5%, 10%, 15% dan 20% kemudian fraksi teraktif dilanjutkan uji dengan metode dilusi dengan konsentrasi 50%, 25%, 12,5%, 6,25%, 3,12%, 1,56%, 0,78%, 0,39%, 0,19% dan 0,095%. Hasil penelitian dengan metode difusi menunjukkan bahwa ekstrak etanol, fraksi n-heksan, fraksi etil asetat dan fraksi air mempunyai aktivitas antibakteri terhadap Staphylococcus aureus. Fraksi yang teraktif adalah fraksi etil asetat konsentrasi 20% dengan rata-rata diameter zona hambat adalah 12,0 mm. Fraksi etil asetat dari daun ubi jalar ungu mempunyai aktivitas antibakteri paling aktif dibandingkan dengan ekstrak etanol, fraksi n-heksan dan fraksi air dilihat dari rata-rata diameter zona hambat yang diperoleh. Metode dilusi dari fraksi etil asetat menunjukkan Konsentrasi Hambat Minimum dan Konsentrasi Bunuh Minimum dari fraksi etil asetat adalah 25%.Kata kunci : Daun ubi jalar ungu, Staphylococcus aureus ATCC 25923, difusi, dilusi.

UJI AKTIFITAS TABIR SURYA DENGAN METODE SUN PROTEKTION FACTOR PADA SEDIAAN LOTION KOMBINASI EKSTRAK KAYU MANIS dan TEMULAWAK Istiara Subekti; Tatiana Siska Wardani; Kusumaningtyas Siwi Artini
Prosiding Seminar Informasi Kesehatan Nasional 2022 : SIKesNas 2022
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Ekstrak kayu manis (Cinnamomum burmanni (Nees & T.Nees) dan ekstrak temulawak(Curcuma zanthorrhiza Roxb.) memiliki aktivitas sun protektion factor (SPF) secara spektroskopi.Penelitian ini bertujuan untuk mengetahui potensi tabir surya dengan pengukuran (SPF) sertamengetahui kategori tabir surya pada sediaan lotion kombinasi ekstrak kayu manis EKM danekstrak temulawak (ETM). Metode penelitian ini menggunakan metode observasi eksperimentaldengan 3 variasi kombinasi V1 EKM 0.25% ETM 0,75% V2 EKM 0,5% ETM 0,5% V3 EKM0,75% ETM 0,25%. Observasi meliputi uji fisik, uji nilai SPF, serta uji stabilitas dengan metodecycling test. Aktivitas tabir surya lotion di tentukan secara spektrofotometri dengan serikonsentrasi 1250ppm, 2500ppm, 3750ppm dan 5000ppm untuk menentukan nilai (SPF). Hasilpenelitian menunjukan V1 memiliki nilai SPF 5,03±15,60 V2 5,47±16,92 dan V3 6,92±18,39.Lotion dengan kombinasi ekstrak kayu manis dan ekstrak temulawak memiliki kategori tingkatkemampuan ultra dibuktikan dengan nilai SPF ≥15. Variasi konsentrasi terbaik adalah V3dibuktikan dengan nilai SPF paling tinggi.

Co-Authors Achmad Fauzi Aisyah Rabitha Alisi Angga Aulia Sahadatun Anita Dwi S Anita Dwi Septiarini Annisa Kusuma Wardhani Aprilia Rika Alvita Aris Prio Agus Santoso Bangkit Riska Permata Belinda Arbitya Dewi Desy Ayu Irma Permatasari dewi mei ika widiyastuti Dinar Aditama Nugroho Era Wandira Galuh Puspita Sari Ilham Latansa Istiara Subekti Kusumaningtyas Siwi Artini Nadia Aisy Andika Nasya Bella Salsabilla Noka Riyani Novalisa Nindhi Soraya Nuraini Putri Rahmawati Nurul Nurhayati Putri Djatmiko Marchia Afifah Putri Martani Nur Afifah Regita Fortunata Rony Setianto Tiara Ajeng Listyani Tiara Ajeng Listyani Veranita Weri Veranita, Weri Yaya Sulthon Aziz

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