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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) E-Jurnal Medika Udayana Media Kesehatan Masyarakat Indonesia Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) Bali Anatomy Journal INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Cokorda Agung Wahyu Purnamasidhi
Tropical And Infectious Diseases Division, Internal Medicine Department, Universitas Udayana, Bali, Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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Journal : BALI MEDICAL JOURNAL (BMJ)

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High Interleukin-6 Level Increases Depression Risk on Geriatric Population in Denpasar, Bali-Indonesia Purnamasidhi, Cokorda Agung Wahyu; Kuswardhani, R.A. Tuty
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: High interleukin-6 (IL-6) serum level was responsible in inflammatory regulation through the interaction within macrophage, glial melatonin production and regulation of methyl CpG- binding protein 2 (MeCP2) and influenced neuro-inflammation process, thus, it increased the risk of depression. The aim of this study was to determine whether high interleukin-6 serum level increased the risk of depression in geriatrics. Methods: A case control was performed as the design of this study. Geriatric populations with depression enrolled as the case group and without depression as control group. Assessment of IL-6 serum level was conducted by the patient’s venous blood. The IL-6 serum> 10 pg/ml was categorized as high. Results: In this study, 30 cases and 30 controls who met the criteria included as samples. There were 20 males (66.7%) and 10 females (33.3%). Factors associated with an increased risk of depression in geriatric were a high level of serum interleukin-6 (OR=3.60; CI95%: 1.22-10.64, p=0.018) and a marital status (OR=3.50; CI95%: 1.11- 1.02, p=0.028). High level of interleukin-6 was a significant and an independent risk factor of depression in geriatric (OR=3.60; CI95%: 1.22-10.64, p=0.021) in multivariate analysis. Conclusion: This study concluded that high IL- 6 serum level increased the risk of depression in geriatric.
Co-Authors Anak Agung Ayu Yuli Gayatri Cokorde Istri Yuliandari Krisnawardani K Darren Junior Darren Junior Dewa Ayu Fony Prema Shanti Dewa Ayu Fony Prema Shanti Giovanca Verentzia Purnama Giovanca Verentzia Purnama Haruko Akatsu I Dewa Ayu Agung Warmadewanthi I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Nyoman Wibawa I Gde Haryo Ganesha I Gede Purna Weisnawa I Gede Purna Weisnawa I Gusti Ngurah Ariestha Satya Diksha I Ketut Agus Somia I Ketut Agus Somia I Ketut Mariadi I Komang Hotra Adiputra I Komang Hotra Adiputra I Komang Hotra Adiputra I Made Susila Utama I Nyoman Gede Narendra Yanakusuma I Wayan Arya Biantara Ida Ayu Laxmi Ananda Dewi Manuaba Jerry Jerry Kadek Diana Harmayani Ketut Tuti Parwati Merati Komang Ayu Witarini Luh Oliva Saraswati Suastika Ni Made Dewi Dian Sukmawati Ni Made Susilawathi Putu Kintan Wulandari Putu Kintan Wulandari R. A.T. Kuswardhani Richard Christian Suteja Richard Christian Suteja Richard Christian Suteja Saktivi Harkitasari, Saktivi Yenny Kandarini