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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences MNJ (Malang Neurology Journal) Universa Medicina Majalah Kesehatan FKUB

Masruroh Rahayu, Masruroh

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Author-ID : 592578

Agriculture, Biological Sciences & Forestry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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CORRELATION OF SEVERE HEAD INJURY EPIDURAL HEMATOMA TREPANATION RESPOND TIME WITH OUTCOME Santoso, Mochamad Istiadjid Eddy; Rahayu, Masruroh; Balafif, Fachriy
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Epidural hematoma is intracranial hemorrhage, due to skull fracture caused by head injury which there is a blood accumulation between the layers of duramater and the skull. Objective. To determine the corellation of epidural hematoma trepanation respond time with outcome. Methods. A retrospective observational analytic study (cross sectional) with 30 samples taken in Saiful Anwar Hospital Malang from June to August 2012. The independent variable in this study is trepanation respond time that divided into trepanation respond time less than 6 hours, between 6-12 hours, between 12-18 hours, between 18-24 hours, and more than 24 hours while the dependent variable in this study is the outcome of the patient. Secondary data were taken using medical records. The data were analyzed using independent T-test, spearman correlation test, kruskall walis test, and ROC test with confidence level 95% (Î±=0.005). Results. The analysis shows a significant corelation between severe head injury epidural hematoma trepanation respond time with the outcome.Conclusion. Faster trepanation respond time will have better outcome.

GERIATRIC PATIENT WITH DELIRIUM PROFILE IN SAIFUL ANWAR GENERAL HOSPITAL MALANG FROM JANUARY 2005 UNTIL JUNE 2010 Sunarti, Sri; Rahayu, Masruroh; Desetyaputra, Dimas Ryan
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. Delirium is a serious health problem and the most frequent complaints in geriatric patients. Objective. This research aims to analyzes the patient profile and the underlying disease of delirum by using descriptive study and survey methods. Methods. Subjects were geriatric patients with age >60 years old diagnosed with delirium.Results. Patients with delirium syndrome was male sex 58.3% and female sex 41,7%, the highest age group between 60-65 years was 31.7% and 66-70 years was 30%, education is the senior high school level of 41.7% and junior high school level of 35%. Temperature delirium patients that >37.5oC (61.7%) patients and GCS due to moderate state was 100% patients. Hb and PCV were below normal at 71.7% and 70%. Conditions out of the hospital patients delirum syndrome is to live for 71.7%. The most underlying disease delirium syndrome were CVA 56.7%, Diabetes Melitus type II 23,3% and Sepsis 8,3%. Conclusion. The factors underlying the occurrence of delirium syndrome are male sex, aged 60-65 years old, low education, temperatures above normal, decreased consciousness, low PCV, anemia and most diseases that cause delirium syndrome is CVA, Diabetes Melitus type II and Sepsis.

DIAGNOSIS AND MANAGEMENT OF NONCONVULSIVE STATUS EPILEPTICUS (NCSE) Pramesti, Fathia Annis; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Rahayu, Masruroh
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Status epilepticus is an emergency condition in the field of neurology are often undiagnosed and are associated with high mortality and long-term disability. One type of status epilepticus is nonconvulsive status epilepticus (NCSE) in which the diagnosis of NCSE is very difficult because the clinical manifestations appear is agitation or confusion, nystagmus or bizarre behavior such as lip smacking or take goods in the air.The diagnosis was based on clinical features, especially the mental status or the disrupted of consciousness and the changes in the EEG. Diagnosis of NCSE is an important first step, which can avoid the delay in therapy in order to prevent irreversible brain damage. Treatment is by administering benzodiazepines and antiepileptic drugs, while the prognosis is determined by the etiology and associated with brain damage there.

NEURAL PAIN PATHWAY TRACING OF RABBIT ISCHEMIC HEART BY DOUBLE-RETROGRADE NEUROTRACING Dapamede, Theodorus; Paundralingga, Obed Trinurcahyo Kinantyo; Rahayu, Masruroh; Soemantri, Bambang
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background. Myocardial ischaemiaÂ leads to angina pectoris or referred pain, whichhappens because of theÂ inability of the brain to distinguish the visceral afferent inputs from the somatic afferent inputs since theyÂ run along a common pathway via the dorsal root ganglia.Objective. To distinguish specific areas of the rabbit heart that are projected to specific dorsalÂ root ganglia, which then associates to its specific dermatomes.Methods. A double-retrograde neurotracing method was used, with True Blue and Nuclear Yellow as theÂ neurotracers. Rabbits were divided into 3 groups, which the first and second groups were ligated at theÂ left anterior descending artery and at the left circumflex artery, respectively.The third group acted as theÂ control group, without ligation.Results. There is significant association between the site of ligation to the projection of the neurotracers atÂ specific dorsal root ganglia (p<0.05). The first group showed high tendency to be projected to T2 and theÂ second group showed a high tendency to project to T1.Conclusion. This study shows that the rabbit heart can be specifically projected neuronally to specificÂ dorsal root ganglia, following coronary artery ligation.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSONâ€™S WISTAR STRAIN RAT (RATTUS NORVEGICUS) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Anggraini, Dini Jatiya
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background.Â BetaÂ glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson'sÂ disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the boneÂ marrow into the damaged tissues.Objective.Â To find out the effects of the addition of Saccharomyces cerevisae toward the number ofÂ brain cells in substantia nigra Parkinsonâ€™s rat model.Methods. Experimental researchÂ in vivo using the draft of randomized post test only controlledÂ group design.Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells.Conclusion.Â The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinsonâ€™sÂ Strain Wistar rat model significantly.

ATTENTION AND INTERNATIONAL HIV DEMENTIA SCALE (IHDS) DO NOT CORRELATE WITH CD4 COUNT IN HIV PATIENTS Arofah, Annisa Nurul; Rianawati, Sri Budhi; Rasyid, Harun Al; Rahayu, Masruroh
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Background. Despite it is common neurocognitive domain that affected in patient with Human Immunodeficiency Virus (HIV) infection, attention domain is not assessed using International HIV Dementia Scale (IHDS), a common screening test to diagnose HIV-associated cognitive disorder. Detection of attention deficit in HIV patient is important as it can maintain the capacity to adherence to antiretroviral therapy and essential to activity daily living. CD4 is one of the markers for severity of HIV infection. Objective. We aims to correlate between CD4 with IHDS and CD4 with attention performance test, such as forward digit span test (FWD), backward digit span test (BWD), and trail making test A test (TMA).Methods. This is an analytic study using cross sectional design. 20 respondents are collected for the study using purposive sampling. Data is collected using instrument IHDS, FWD, BWD, and TMA.Results. Using the correlation of Eta, Eta 2 of CD4 and IHDS, CD4 and FWD, CD4 and BWD, also CD4 and TMA are 0.025, 0.022, 0.022 and 0.011.Conclusion. We concluded that CD4 have no correlation with test for attention domain and IHDS.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSONâ€™S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Hermawan, Hanestya Oky
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae.Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group.Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinsonâ€™s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.

THE ROLE OF TNF-Î± AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS Wibowo, Agung Prasetyo; Sujuti, Hidayat; Rahayu, Masruroh; Muid, Masdar; Kawuryan, Siti Lintang
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Background. One of pediatric emergencies that has high mortality is status epilepticus (SE). Correlation between tumor necrosis factor (TNF)-Î±, interleukin (IL)-6, and SE had been reported but human study of it is limited. Objective. To compare TNF-Î± and IL-6 level in children with SE to those of children without SE and to find correlation between both cytokines.Methods. Cross-sectional study was conducted in dr.Saiful Anwar Hospital Malang with 48 children were enrolled in this study. All subjects were divided into three groups, including children who had SE; children who had seizure but not SE; and children who have no seizure. The levels of TNF-Î± and IL-6 serum were measured by ELISA.Results. TNF-Î± and IL-6 serum level were not significantly different between groups (p=0.920, p=0.829). We found interesting fact that the level of IL-6 in children with SE who have no disability was significantly higher than that of children who died or had disability (p=0.015). There was strong correlation between TNF-Î± and IL-6 in SE group (R 2 = 0.841 and p = 0.0001).Conclusion. IL-6 serum level was higher in SE children who have no disability and correlate with TNF-Î± serum level.

Catechins decrease neurological severity score through apoptosis and neurotropic factor pathway in rat traumatic brain injury Ratnawati, Retty; Arofah, Annisa Nurul; Novitasari, Anastasia; Utami, Sartika Dewi; Hariningsih, Made Ayu; Rahayu, Masruroh; Rianawati, Sri Budhi; Purnomo, Hari; Dalhar, Mochammad
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.110-122

BACKGROUNDCatechins inhibits apoptosis through anti oxidant and anti inflamation pathway. Catechins also increases brain-derived neurotrophic factor (BDNF). There was a few research that explained the role of catechins in traumatic brain injury (TBI). The objective of the study was to evaluate the effect of catechins administration on neurologic severity score (NSS) through apoptosis and neurotropic pathway in traumatic brain injury rat model.METHODSA post test only controlled group design was performed using traumatic brain injury rat (Rattus novergicus) model through weight drop models. It was devided into negative control group, positive control group, TBI+catechins 513 mg/kgBW, TBI+catechins 926 mg/kgBW, TBI+catechins 1113 mg/kgBW. NSS was measured in the first hours, day three, and day seven. The expressions of NFkB, TNFa, Bcl-2, Bax, caspase 3, caspase 8, BDNF, and the numbers of apoptosis cells were evaluated by imunohistochemystry method. One way Anova and Kruskal Wwallis were used to analyse the data.Results TNFa, caspase 8, number of apoptosis cells were significantly decreased on the seventh day administration compared to the third day administration (p<0.05). Catechins increased the expression of Bcl-2/Bax and BDNF significantly (p<0.05). Yet, there were no significant differences between expression of caspase 3, NSS, Bcl-2/Bax ratio, and BDNF toward third days administration of catechins compared with seven days administration (p>0.050).ConclusionsAdministration of catechins decreased NSS through inhibiting inflammation and apoptosis, as well as induced the neurotrophic factors in rat brain injury. Catechins may serve as a potential intervention for TBI.

HUBUNGAN MEAN ARTERIAL BLOOD PRESSURE DENGAN KELUARAN PASIEN STROKE TROMBOTIK YANG DINILAI DENGAN SKOR NIHSS Rahayu, Masruroh; Rakhmani, Alidha Nur; Raisa, Neila; Ar Rahmah, Kurnia Auliyana
Majalah Kesehatan FKUB Vol 5, No 3 (2018): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Hipertensi merupakan salah satu faktor risiko stroke. Beberapa penelitian menyatakan peningkatan tekanan darah sistol dan diastol pada stroke iskemik menyebabkan keluaran yang buruk pada pasien stroke. Namun berdasarkan penelitian lain, peningkatan tekanan darah sistemik memiliki efek proteksi sehingga menurunkan tingkat keparahan stroke. Penelitian ini bertujuan untuk mengetahui hubungan mean arterial blood pressure (MABP) dengan keluaran pasien stroke trombotik yang diukur dengan skor Delta National Institutes of Health Stroke Scale (NIHSS). Penelitian ini menggunakan subjek pasien stroke yang dirawat di Stroke Unit RS. Dr. Saiful Anwar Malang selama periode April - Juni 2016 dengan jumlah sample 30 pasien. Kriteria inklusi usia pasien >18 tahun, onset stroke <24 jam, dan diagnosis stroke dengan CT scan kepala sebagai gold standard. NIHSS dan tekanan darah diukur 24 jam pertama sejak terdiagnosis stroke dan NIHSS kembali diukur pada hari 14. Delta NIHSS didapatkan dari NIHSS hari ke 14 dikurangi NIHSS masuk. Penelitian ini menggunakan desain peneltian cross sectional. Berdasarkan hasil analisis didapatkan korelasi yang signifikan antara MABP dengan Delta NIHSS (p = 0,025, r = -0,408) dengan arah korelasi negatif. Semakin tinggi nilai MABP maka akan semakin negatif delta NIHSS. Semakin negatif nilai Delta NIHSS menunjukkan semakin baik klinis dari pasien stroke.Â Kata kunci: delta NIHSS, MABP, sistol, diastol, stroke.

Co-Authors Agung Prasetyo Wibowo Alam, Ahmad Bayhaqi Nasir Anastasia Novitasari, Anastasia Annisa Nurul Arofah, Annisa Nurul Ar Rahmah, Kurnia Auliyana Ardani Galih Prakosa, Ardani Galih Ariani Ariani Bambang Soemantri, Bambang Dalhar, Mochamad Diana Lyrawati Dimas Ryan Desetyaputra, Dimas Ryan Dini Jatiya Anggraini, Dini Jatiya Fachriy Balafif, Fachriy Hanestya Oky Hermawan, Hanestya Oky HARI PURNOMO Harun Al Rasyid Hidayat Sujuti Islani, Ahmad Zaki Sukma Krisni Subandiyah M Aris Widodo M. Ihwan Narwanto Machlusil Husna, Machlusil Made Ayu Hariningsih, Made Ayu Masdar Muid Mochammad Dalhar Nurdiana Nurdiana Paundralingga, Obed Trinurcahyo Kinantyo Pramesti, Fathia Annis Raisa, Neila Rakhmani, Alidha Nur Restuningwiyani, Sintha Retty Ratnawati Risma Karlina Prabawati Santoso, Mochamad Istiadjid Eddy Sartika Dewi Utami, Sartika Dewi Setyawati Soeharto, Setyawati Shahdevi Nandar Kurniawan, Shahdevi Nandar Siti Lintang Kawuryan Sri Budhi Rianawati, Sri Budhi Sri Sunarti Theodorus Dapamede, Theodorus Widjadjanto, Edi

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