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Hubungan Polimorfisme Gen XRCC1 Arg399Gln Terhadap Kejadian Kanker Serviks Pada Wanita Ras Melayu Sary, Mega; Legiran, Legiran; Saleh, Irsan
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 4, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.V4I1.7958

Abstract

Kanker serviks merupakan kanker yang terjadi pada serviks atau leher rahim, suatu daerah yang terletak pada organ reproduksi wanita yang merupakan pintu masuk ke arah rahim, letaknya antara rahim (uterus) dan liang senggama atau vagina. Insiden terjadinya kanker serviks dipengaruhi oleh Human Papiloma Virus (HPV), usia, usia terlalu muda berhubungan seksual, paritas, riwayat keluarga dan RAS. Gen XRCC1 sebagai perancah dalam BER yang terlibat dalam membantu memperbaiki kesalahan-kesalahan selama replikasi DNA serta  menjaga integritas genom. Single Nukleotida Polymorphism (SNP) di XRCC1 telah dikaitkan dengan pengembangan yang terjadi pada kanker serviks yang dapat mengurangi aktivitas perbaikan DNA, meningkatkan terjadinya mutasi sehingga kerentanan terhadap kanker. Penelitian ini bertujuan untuk melihat adakah hubungan polimorfisme gen XRCC1 Arg399Gln dengan kejadian kanker serviks. Penelitian ini merupakan penelitian observasional analitik dengan desain case-control dengan jumlah sampel sebanyak 35 orang wanita kanker serviks dan 35 orang wanita normal yang setiap sampel memiliki RAS melayu Jambi. Identifikasi polimorfisme gen XRCC1 Arg399Gln dilakukan dengan teknik PCR-RLFP amplifikasi dengan primer spesifik yang digunakan untuk melihat mutagenesis. Hasil analisis dengan uji Chi-Square genotipe G/G (Wild Type), G/A (Mutant Heterozigot) dan G/A (Mutant Heterozigot) terhadap kanker serviks nilai ? = 0,032 (OR : 10.074 ; CI : 1,186 -85,570). Kesimpulan ada hubungan polimorfisme genotip gen XRCC1 Arg399Gln terhadap kejadian kanker serviks pada wanita RAS Melayu Jambi. 
Pengaruh Pemberian Ekstrak dan Fraksi Metanol Air Buah Kurma Ajwa (Phoenix Dactylifera) terhadap Berat, Histologi Epididimis, Dan Morfologi Spermatozoa Tikus Jantan (Rattus Norvegicus) Nurjanah, Fitri; Salni, Salni; Legiran, Legiran
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Tingkat infertilitas laki-laki diseluruh dunia berkisar 2,5 sampai 12% dan lebih dari 30 juta pria dunia tidak subur. WHO menyatakan lebih dari 50% penyebab infertlitas pihak pria yang terbesar disebabkan faktor semen. Buah kurma ajwa (Phoenix dactylifera) mampu mengobati infertilitas karena memiliki aktivitas sebagai antioksidan dan gonadotropik. Tujuan mengetahui pengaruh pemberian ekstrak dan fraksi metanol air kurma ajwa terhadap berat epididimis, tebal epitel epididimis dan morfologi spermatozoa pada tikus putih jantan (Rattus norvegicus).Penelitian ini eksperimental menggunakan rancangan Acak Lengkap (RAL) dengan 25 sampel tikus putih jantan dengan diberi perlakuan ekstak, fraksi metanol air kurma ajwa dan CMC 1% (kontrol) selama 35 hari, selanjutnya di ambil organ epididimisnya untuk dilakukan penimbangan organ, histologi dan penambilan semen. Hasil penelitian ini menunjukkan terdapat peningkatan berat epididimis, tebal epitel epididimis dan morfologi spermatozoa dibandingkan kelompok kontrol. Fraksi metanol air dengan dosis 300mg/kgBB mempunyai pengaruh paling kuat. Disimpulkan bahwa ekstrak dan fraksi metanol air kurma ajwa (Phoenix dactylifera) dapat meningkatkan berat, histologi epididimis dan morfologi spermatozoa.
Effects of Neoadjuvant Fluorouracyl-Adriamycin- Cytoxan (FAC) Chemotherapy Response to CD4 + Serum Levels In Breast Cancer Ade Permana; Benny Kusuma; Nur Qodir; Legiran
Sriwijaya Journal of Surgery Vol. 1 No. 1 (2018): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.31 KB) | DOI: 10.37275/sjs.v1i1.1

Abstract

Introduction. CD4+ T-helper has an important role in immune system modulation especially to maintain long-term anti tumor effect. CD4+ also serves to activate CD8+ for destroyed the tumor cells. It was expected there were role of immunity on tumor growth and response of breast cancer chemotherapy to CD4+ levels serum. Furthermore, this study was aimed to investigate the effects of neoadjuvant chemotherapy on CD4+ levels in patients with locally advanced breast cancer at General Hospital Dr. Mohammad Hoesin Palembang. Method. This study was a non-comparable clinical trial by looking at serum CD4+ levels in patients with locally advanced breast cancer before and after neoadjuvant chemotherapy. Results. Of the 30 subjects the subject age ranged from 33-66 years with an average of 45 years. There were 17 patients with contraception history (56.7%), 13 patients with family history of breast cancer (43.3%). From this study, it was obtained 23 patients with good chemotherapy response (76.7%) and there were 7 patients who had poor chemotherapy response after neoadjuvan chemotherapy (23.3%). Paired t-test analysis showed that there was a significant difference in mean CD4+ count before and after neoadjuvan chemotherapy. At the CD4+ level before chemotherapy 775.55 had a sensitivity of 60% and a specificity of 57% (cut of point). While CD4+ levels after chemotherapy 470.85 with sensitivity of 60% and specificity of 57%. Conclusion. CD4+ pre-chemotherapy examination had a sensitivity score of 60% and a specificity of 57% in predicting neoadjuvant chemotherapy response.
Revised Trauma Score (RTS) as a Mortality Predictor on Abdominal Trauma Ade Dian Anggraini; Efman EU Manawan; Legiran
Sriwijaya Journal of Surgery Vol. 1 No. 1 (2018): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.823 KB) | DOI: 10.37275/sjs.v1i1.3

Abstract

Introduction: Trauma is a major health problem throughout the world. Trauma is the most common cause of death and the most common cause of disability in adults and young adults. Abdominal trauma accounts for 7-10% of all trauma sufferers and causes severe trauma. The purpose of this study was to determine the relationship between the Revised Trauma Score (RTS) to the mortality of abdominal trauma sufferers. Methods: This study was an observational analytic study with a retrospective design to assess the relationship between Revised Trauma Score (RTS) and mortality in abdominal trauma patients treated in the Emergency Department of RSUP DR. Mohammad Hoesin Palembang. Data collected were analyzed using SPSS-23 devices using the chi-square method and Mann Whitney Results: 144 abdominal trauma patients studied. The mean age was 28 ± 11,340 years, 97.4% were male, 64.0% of patients had abdominal trauma. The average RTS value was 7.429 ± 1,001. The mean value in the group of patients who died was 6.628 ± 0.795 and the mean value of the RTS in the group of patients who did not die was 7.459 ± 0.795. There was a significant relationship between RTS values ​​and mortality in abdominal trauma patients (p = 0.0.03). Conclusion: the results of this study indicate that RTS is a meaningful assessment system in predicting death in abdominal trauma patients
Development of Scoring System for Prediction of Choledocholithiasis Danny Amos Tarigan; Hafid Komar; Legiran
Sriwijaya Journal of Surgery Vol. 1 No. 1 (2018): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.806 KB) | DOI: 10.37275/sjs.v1i1.4

Abstract

Introduction. Gallstones (cholelithiasis) and gallbladder stones (choledocholithiasis) are still a public health problem because of the high incidence rate. Management of stones in common bile duct (CBD) is done with history taking about patient complaints and tracking patient history such as yellow appearance, physical examination, laboratory examination, and imaging examination before, during and after surgery. Of the many imaging assessment that can be done, in practice not all can be done because these tests are expensive, complicated, risk of morbidity and mortality. A scoring system that includes many parameters can be very useful for many surgeons to be able to assess the presence of gallbladder stones. Methods. The study was an analytic observational study with a cross sectional study design carried out in the digestive surgery polyclinic and the inpatient installation of Dr. Moh Husein general hospital, Palembang from September 2018 to May 2019. The sample of this study was all patients suspected of having gallbladder stones that met the inclusion and exclusion criteria. Results: Receiver operating characteristic (ROC) analysis of scoring on bile duct stone diagnosis had a cut-off of> 4 with a sensitivity value of 100% and a specificity of 75%. In the Fisher's Exact analysis test and it was found that the scoring had a significant relationship to the diagnosis of bile duct stones with an odd ratio (OR) value of 12.52. Conclusion. The use of a scoring system can predict the incidence of gallbladder stones.
Comparison of Hip Functional Value and Quality of Life Between Cemented and Uncemented Hip Arthroplasty Patients Fredy Ferdinand Carol; Wiria Aryanta; Legiran
Sriwijaya Journal of Surgery Vol. 1 No. 1 (2018): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.28 KB) | DOI: 10.37275/sjs.v1i1.5

Abstract

Abstract Introduction. Hip arthroplasty is aimed to reduce pain and restore hip joint function. Until now, the most optimal method for fixation in Hip Arthroplasty is controversial. The purpose of this study was to analyze the comparison of hip functional value and quality of life between cemented and uncemented hip arthroplasty patients. Methods. This study used cross sectional design. Data were collected via medical record and SF-12 questionnaire and Oxford hip score in patients who have received hip arthroplasty at general hospital Dr. Moh. Hoesin Palembang. Results: There were 43 cases found, consisting of 28 cemented cases and 15 uncemented cases. The average age was 60.42 ± 19.44 years with an age range of 24-88 years. 20 subjects (46.4%) and 23 subjects (53.5%) women. The most preoperative diagnosis was trauma / fracture (69.8%), followed by osteoarthritis (16.3%), osteonecrosis (4.7%). Previous normality tests have been done with the Sapiro-Wilk test and homogeneity test. A comparison of hip functional values ​​between cemented and uncemented hip arthroplasty patients had a value of p = 0.76 (p <0.05) meaning there was no significant difference. Comparison of quality of life between cemented and uncemented hip arthroplasty patients has a value of p = 0.592 (p <0.05) which also means there is no significant difference. Conclusion: There was no difference in pelvic functional value and quality of life between cemented and uncemented hip arthroplasty patients.
Dukungan Petugas terhadap Kepatuhan Imunisasi Hepatitis B pada Wilayah Kerja Puskesmas Ariodillah Kota Palembang Ridwan, Achmad; Legiran, Legiran
Syifa'Medika Vol 6, No 1 (2015): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v6i1.1378

Abstract

Data World Health Organization (WHO) tahun 2012 memperkirakan bahwa satu individu yang hidup telah terinfeksi hepatitis B, sehingga lebih dari 200 juta orang di seluruh dunia terinfeksi. Cakupan imunisasi hepatitis di Puskesmas Ariodillah masih rendah yaitu Hepatitis B (0-7) hari uniject 6,9%, DPT-HB1 8,2% dan DPT-HB2 8,0% dari standar yang ditargetkan yaitu sebesar 100%. Penelitian ini bertujuan untuk mengetahui pengetahuan dan sikap ibu serta dukungan petugas terhadap kepatuhan imunisasi Hepatitis B di wilayah kerja Puskesmas Ariodillah Palembang dengan menggunakan penelitian analitik observasional melalui pendekatan cross sectional. Metode pengumpulan data menggunakan teknik cluster sampling. Jumlah sampel penelitian adalah 178 subjek. Dari 178 subjek diperoleh 137 subjek (77,0%) yang patuh dan 41 subjek (23,0%) tidak patuh terhadap imunisasi Hepatitis B. Hasil penelitian menunjukkan sebagian besar responden yang patuh imunisasi hepatitis B memiliki pengetahuan baik (86,2%), memiliki sikap positif (82,8%), dan memiliki dukungan petugas yang baik (55,6%). Tenaga kesehatan diharapkan lebih meningkatkan pengetahuan dan sikap ibu mengenai imunisasi Hepatitis B serta meningkatkan pelayanan yang lebih baik.
Prevalensi Nyeri Muskuloskeletal Pada Pengemudi Becak Kayuh Di Palembang Sugiharto, Henry; Chandra, Novy Rosalia; Legiran, Legiran
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Musculoskeletal system is a system consisting of bones, joints, muscles, tendons and ligaments, that provides body support and facilitates movement. Musculoskeletal pain is defined as persistent or recurring pain that arises as part of a disease process that directly affects the associated bones, muscles, joints or soft tissue. Highest incidence of health problems experienced by workers based on research conducted on 9,482 workers in 12 cities in Indonesia was musculoskeletal disorders (16%). Among various types of work, public transport drivers in various parts of the world have highest prevalence of musculoskeletal pain disorder, ranging from 53% to 91%. A descriptive cross-sectional study design ofpedicab rickshaw driverswas conducted at Kemuning District, Palembang. Primary data were collected by interviews and simple neurological clinical examinations. All data was processed using SPSS 22 for windows. The results found highest prevalence of musculoskeletal pain in people older than 51 years (60%) and affected 74.3% of subject who worked as pedicab rickshaw drivers. Most subject (77.2%) have a normal body mass index. From this study, we found that lower extremities were the most common site of musculoskeletal pain (77.1%) with 64.7% subject reported a mild pain intensity.
Faktor-Faktor yang Mempengaruhi Kepatuhan Berobat Pasien Kanker Payudara yang Menjalani Kemoterapi di RSUP Dr. Mohammad Hoesin Palembang Indah, Furqan; Qodir, Nur; Legiran, Legiran
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Breast cancer affects 2.1 million women every year and is the biggest cause of cancer death in women in the world. Therapy for breast cancer is one of them with chemotherapy. Adherence is required in undergoing treatment to avoid the progression and recurrence of the disease. This type of research is observational descriptive with consecutive sampling techniques. The sample of this study were breast cancer patients who underwent chemotherapy at RSUP Dr. Mohammad Hoesin in September 2019 who met the inclusion and exclusion criteria. The instruments in this study were the Patient Compliance Questionnaire Undergoing Chemotherapy and the Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire. In this study, 49 breast cancer patients were the subjects of the study. The results of the study the most age group were 50-54 years with a percentage of 22.4% (n=11), the level of education was the secondary school 42.9% (n=21), and family income below the provincial minimum wage 57,1% (n=28). All subjects (n=49) had insurance and chemotherapy side effects. According to the assessment, there were 24.5% (n=12) were depressed, 91.8% (n=45) obedient and not compliant with treatment by 8.2% (n=4). The reason for compliant treatment is the desire to recover and family. Patients not complying is because of the distance of the house and the side effects. Five factors that influence the compliance of treatment are social and economic, health care team and system, condition, therapy, and patient-related factors.
Pengaruh Pemberian Ekstrak dan Fraksi Metanol Air Buah Kurma Ajwa (Phoenix Dactylifera) terhadap Berat, Histologi Epididimis, Dan Morfologi Spermatozoa Tikus Jantan (Rattus Norvegicus)Tingkat infertilitas laki-laki diseluruh dunia berkisar 2,5 sampai 12% Fitri Nurjanah; Salni; Legiran
Biomedical Journal of Indonesia Vol. 3 No. 2 (2017): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Abstract

Tingkat infertilitas laki-laki diseluruh dunia berkisar 2,5 sampai 12% dan lebih dari 30 juta pria dunia tidak subur.WHO menyatakan lebih dari 50% penyebab infertlitas pihak pria yang terbesar disebabkan faktor semen. Buahkurma ajwa (Phoenix dactylifera) mampu mengobati infertilitas karena memiliki aktivitas sebagai antioksidan dangonadotropik. Tujuan mengetahui pengaruh pemberian ekstrak dan fraksi metanol air kurma ajwa terhadap beratepididimis, tebal epitel epididimis dan morfologi spermatozoa pada tikus putih jantan (Rattusnorvegicus).Penelitian ini eksperimental menggunakan rancangan Acak Lengkap (RAL) dengan 25 sampel tikusputih jantan dengan diberi perlakuan ekstak, fraksi metanol air kurma ajwa dan CMC 1% (kontrol) selama 35 hari,selanjutnya di ambil organ epididimisnya untuk dilakukan penimbangan organ, histologi dan penambilan semen.Hasil penelitian ini menunjukkan terdapat peningkatan berat epididimis, tebal epitel epididimis dan morfologispermatozoa dibandingkan kelompok kontrol. Fraksi metanol air dengan dosis 300mg/kgBB mempunyai pengaruhpaling kuat. Disimpulkan bahwa ekstrak dan fraksi metanol air kurma ajwa (Phoenix dactylifera) dapatmeningkatkan berat, histologi epididimis dan morfologi spermatozoa.