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Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis Alkaf, Syifa; Chakra, Aerul; Said, Usman; Saleh, Irsan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (p

Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis Alkaf, Syifa; Chakra, Aerul; Said, Usman; Saleh, Irsan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (p

Hubungan Pola Makan dengan Risiko Terjadinya Sindrom Ovarium Polikistik pada Remaja Irene, Angela; Alkaf, Syifa; Zulissetiana, Eka Febri; Usman, Fatimah; Larasaty, Veny
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women with broad consequences that affect every aspect of a woman's life, with the incidence of PCOS in adolescents approximately 11-26%. More than 50% of PCOS patients are associated with metabolic syndrome including obesity, insulin resistance, and dyslipidemia. Studies said that diet plays an important role as a risk factor for PCOS in adolescents. Therefore the importance of dietary arrangements to improve hormonal disorders and long-term effects due to PCOS, so it is necessary to do further analysis of the relationship between eating patterns and the risk of PCOS occurrence in adolescents aged 15-19 years in the city of Palembang. This study was an observational study with a cross-sectional design. The data taken is primary data on adolescents aged 15-19 years in Palembang City. Retrieval of data intake on respondents was carried out with a food recall questionnaire, which is then for calorie and macronutrient calculations using nutrisurvey software. The diagnosis of PCOS is established by finding two of the three Rotterdam criteria. From a total of 150 samples, most with normal menstrual cycles, overweight/obese BMI, calorie intake, excess carbohydrate and fat consumption, adequate protein consumption, and less fiber consumption. There were 38 samples (25.3%) obtained with Polycystic Ovary Syndrome (PCOS). Samples that have PCOS, mostly with overweight/obese BMI (p <0.05), calorie intake, consumption of carbohydrates, protein, excess fat (p<0.05), and less fiber consumption (p>0.05). There is a significant relationship between calorie intake, consumption of carbohydrates, protein, and excess fat, as well as less fiber consumption and the risk of Polycystic Ovary Syndrome (PCOS) in adolescents aged 15-19 years in the city of Palembang.

Risk Factors Analysis of Low Back Pain in Pregnancy Syifa Alkaf; Eka Febri Zullisetiana; Fitriah Masturah; Sarrah Ummah Muslimah
JURNAL KEDOKTERAN DAN KESEHATAN Vol 6, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V6I3.9436

Low back pain (LBP) adalah hal yang umum terjadi pada populasi. Uniknya, pada perempuan, LBP terjadi pertama kali umumnya saat kehamilan. Dilaporkan kurang lebih 60% wanita hamil mengalami LBP dalam berbagai tingkatan. Meskipun frekuensi LBP dalam kehamilan cukup tinggi, data pasti mengenai prevalensi LBP dalam kehamilan masih sedikit. Identifikasi faktor resiko dan efektifitas intervensi yang dapat dilakukan terhadap penderita juga belum banyak dilaporkan. Dalam penelitian ini dilakukan identifikasi mengenai prevalensi, karakteristik, serta faktor risiko LBP pada ibu hamil. Penelitian menggunakan desain potong lintang dilakukan dengan wawancara terstruktur dan pemeriksaan fisik untuk menetapkan diagnosis dan mencari faktor risiko. Faktor risiko yang didapat bermakna secara statistik adalah riwayat LBP sebelumnya, baik saat hamil maupun tidak hamil, pekerjaan berisiko, kurangnya aktifitas fisik, serta kebiasaan berlibur. Setelah dilakukan analisis multivariat, kebiasaan berlibur tidak menjadi faktor risiko signifikan. Adanya pengetahuan mengenai faktor risiko ini diharapkan dapat membantu klinisi untuk menentukan intervensi yang tepat guna mencegah dan mengatasi LBP pada kehamilan.

Obstroctuvie Sleep Apnea dalam Kehamilan Syifa Alkaf; Peby Maulina Lestari; Sofyan Effendi
Majalah Kedokteran Sriwijaya Vol 46, No 4 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i4.2724

Obstructive sleep apnea (OSA) adalah gangguan tidur yang banyak terjadi pada wanita hamil, dengan prevalensi sebesar 0,3 sampai 5% dari semua wanita hamil. OSA terjadi karena penutupan komplit ataupun inkomplit hidung dan faring secara intermiten, dengan obesitas sebagai fakor risiko mayor. Pasien OSA akan mengalami mengantuk, rasa lelah, serta sakit kepala di siang hari. OSA pada wanita hamil berhubungan dengan kejadian hipertensi dalam kehamilan termasuk preeklampsia, kelahiran preterm, dan tingginya kelahiran sesar akibat inertia uteri. Berkurangnya aliran darah plasenta ke janin pada penderita OSA berhubungan dengan luaran janin yang buruk antara lain pertumbuhan janin terhambat, bayi berat lahir rendah, dan penurunan nilai Apgar akibat hipoksia intra uterin. Penurunan berat badan, perbaikan pola hidup, dan perubahan posisi tidur dikatakan efektif memperbaiki gejala OSA pada wanita hamil. Penggunaan CPAP sampai pembedahan merupakan pilihan terapi pada penderita OSA derajat berat.

Identification of Lactic Acid Bacteria Isolate From Fermentation Food Bekasam Ardesy Melizah; Syarif Husin; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.34

Bekasam is a local food from South Sumatera Indonesia, which is obtained through fermentation of fish. Previous study has shown that fermented food contained Lactic Acid Bacteria (LAB) bacteria, such as Lactobacillus plantarum, Lactobacillus sp, Pediococus sp and Weissella sp. The study was conducted to identify isolate LAB from bekasam. Bekasam contained fish, rice, and salt with a certain ratio. Further isolation of isolated LAB isolate, then performed PCR for bacterial analysis. Isolate 1 showed alleged bacteria Staphylococcus sp, non pathogen, while isolate 2 leads to Lactobacillus sp. The PCR results show the suitability of the bands formed between the Lactobacillus standard and the isolates. Keywords: bacteria, lactobacillus, acid

The Association between Aromatase Gene Polymorphism Cyp19 Val 80 and Endometriosis Risk Syifa Alkaf; Ziske Maritska; Venny Patricia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.230

Background: Endometriosis implant has been known to express aromatase enzyme, Cytochrome p450 that catalyzes androgen into estrogen. It causes local estrogen production, leading to increased estrogen level, and subsequently triggers endometriosis lesion. CYP19 gene resided at chromosome 15q21.1 is the biggest component of aromatase coding cytochrome p450 enzyme. Objective: To identify relationship between aromatase gene polymorphism CYP19 Val 80 and the risk of endometriosis. Methods: This is an observational case-control study using frozen DNA sample from women with endometriosis and/ or adenomyosis who had undergone laparotomy/ laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang January-November 2013. Samples were amplified and cut by PCR-FRLP using Rsa1 restriction enzyme. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Results: PCR-RFLP results for A/A genotype were 20 (21.3%) in endometriosis group and 8 (8.5%) in control group. G/A genotype were 18 (19.1%) in endometriosis group and 22 (23.4%) in control group. G/G genotype were 9 (9.6%) and 17 (18.1%) in endometriosis group and control group, respectively. There was significant increase risk of endometriosis in women carrying genotype A/A to those with genotype G/G with OR 4.722 (p<0.05). Conclusion: Polymorphism on aromatase gene CYP19 Val 80 A/A increases risk of endometriosis.

Characteristics of Endometriosis Patients in Dr. Mohammad Hoesin General Hospital on 2018 to 2020 Ratu Tenny Leriva; Iskandar Zulqarnain; Hadrians Kesuma Putra; Awan Nurtjahyo; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.478

Background. Endometriosis is defined as the presence of endometrial-like tissue outside the uterus. The prevalence of endometriosis is not known with certainty because it is necessary to perform a laparoscopy to confirm the diagnosis of endometriosis and is usually found during examination for other indications. This study aims to explore the characteristics of endometriosis patients at Dr. Mohammad Hoesin General Hospital Palembang. Methods. This research is descriptive observational research. The research data were obtained from the medical records of endometriosis patients treated at Dr. Mohammad Hoesin General Hospital Palembang from 2018 to 2020. Results. Of the 105 sample data studied, the most distribution of endometriosis patients was in the reproductive age group (15-49 years) (99%), menarche 12-14 years (67.6%), the location of endometriosis in the ovaries (58.1%), status indoor workers (99%), marital status (85.7%), fertile (43.8%), and infertile patients (41.9%), the chief complaint of dysmenorrhea (66.7%), stage IV disease (63, 8%), nullipara (60%), surgical management (79%). Conclusion. Most of the characteristics of endometriosis patients were in the reproductive age group (15 – 49 years), menarche 12-14 years, endometriosis location in the ovary, indoor worker status, marital status, infertility, the main complaint of dysmenorrhea, stage IV disease, nullipara, surgical treatment.

Maternal Obesity Increases Risk for Adverse Maternal Outcome at RSUP Dr. Mohammad Hoesin Palembang Syifa Alkaf; Optima Fitra Ilhami; Mutiara Budi Azhar; Nuswil Bernolian; Ardesy Melizah
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Objective: To find the relationship between level of obesity and adverse maternal outcomes in pregnant women Method: An observational analytic study with a cross sectional design with secondary data from medical record. Subjects were pregnant women who gave birth at RSUP Dr. Mohammad Hoesin Palembang in January 2015-December 2017. Samples were taken by purposive sampling technique. BMIs were divided into 5 categories based on WHO criteria, normoweight, overweight, obese level I, II, and III. Underweight was excluded from the study.Result: Of 252 research subjects, 94 (37.3%) were subjects with normal BMI, 102 (40.5%) were overweight, 44 (17.5%) were obese level I, 6 (2.4%) were level II, and 6 (2.4%) were level III. The maternal outcome consisted of 135 cases (53.6%) of preeclampsia, 6 cases of gestational diabetes mellitus (2.4%), 41 cases of uterine inertia (16.3%), 56 cases of preterm labor (22.2%), assisted delivery 111 cases (44%), and healthcare associated infections (HAIs) 6 cases (2.4%). Further analysis showed that increased level of maternal obesity is related significantly with preeclampsia, gestational diabetes mellitus, uterine inertia, and assisted delivery.Conclusion: There are statistically significant association between obesity level and the incidence of preeclamsia, gestational diabetes, uterine inertia and assisted delivery.Obesitas Pada Wanita Hamil Meningkatkan Morbiditas Maternal Di RSUP Dr. Mohammad Hoesin PalembangAbstrakTujuan: Untuk menemukan hubungan antara tingkat obesitas dengan luaran maternal pada wanita hamil. Metode: Studi analitik observasional dengan desain potong lintang menggunakan data sekunder rekam medis. Subjek adalah wanita hamil yang melahirkan di RSUP Dr.Mohammad Hoesin Palembang pada Januari 2015 - Desember 2017. Sampel diambil secara purposive sampling. Indeks massa tubuh (IMT) dibagi menjadi 5 sesuai kriteria WHO, yaitu normal, berat badan lebih, obesitas level I, II, dan III. Berat badan kurang diekslusi dari penelitian. Hasil: Subjek penelitian dari 252 orang, 94 (37.3%) subjek dengan IMT normal, 102 (40.5%) subjek berat badan berlebih, 44 (17.5%) obesitas level I, 6 (2.4%) obesitas level II, dan 6 (2.4%) obesitas level III. Luaran maternal terdiri dari 135 kasus (53.6%) of preeklampsia, 6 kasus diabetes mellitus gestasional, 41 kasus inertia uteri (16.3%), 56 kasus persalinan preterm (22.2%), 111 kasus (44%) persalinan pervaginam berbantu, dan infeksi luka 6 kasus (2.4%). Analisis menunjukkan adanya tingkatan obesitas maternal berkaitan secara signifikan dengan kejadian preeklampsia, diabetes mellitus gestasional, inertia uteri, dan persalinan pervaginam berbantu. Kesimpulan: Terdapat hubungan antara tingkat obesitas pada ibu hamil dengan preeklampsia, diabetes mellitus gestasional, dan persalinan pervaginam berbantu. Kata kunci: Indeks Massa Tubuh, Obesitas, Luaran Maternal, Morbiditas.

Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis Syifa Alkaf; Aerul Chakra; Usman Said; Irsan Saleh
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 1, January 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (p

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