AbstractPurpose of this study is to determine the effectiveness of the application of the Creative Problem Solving in the respiratory system of learning material in SMAN 1 Jatibarang Brebes.The study was conducted with one- shot case study design. The study population was all students of class XI of SMAN 1 Jatibarang Brebes school year 2013/2014. The sample was 2 class, XI Science 1 and XI Science 2. Procedure research: preparation, execution, data collection , and data analysis. Method of data collection: observation sheets, final test, the results of discussions and questionnaires.Methods of data analysis: descriptive quantitative and qualitative.The results of the study were taken in the form of activities and student learning outcomes. Proven by the achievement of mastery learning which amounted to 93.94 % and student activity is high and very high with a percentage of 80.02 %. Based on the results of the study concluded that learning by using the Creative Problem Solving model of learning material in the respiratory system SMAN 1 Jatibarang Brebes can be applied because it proved effective .  Abstrak Penelitian ini bertujuan untuk mengetahui keefektifan penerapan model Creative Problem Solving dalam pembelajaran materi sistem pernapasan di SMAN 1 Jatibarang Brebes. Penelitian dilakukan dengan desain one shot case study. Populasi penelitian adalah seluruh siswa kelas XI SMAN 1 Jatibarang Brebes tahun ajaran 2013/2014. Sampel penelitian ini adalah 2 kelas dari 3 kelas yaitu kelas XI IPA 1 dan XI IPA 2. Prosedur penelitian: persiapan, pelaksanaan, pengambilan data, dan analisis data. Cara pengambilan data: lembar observasi, tes akhir, hasil diskusi dan angket. Metode analisis data: deskriptif kuantitatif dan kualitatif. Hasil penelitian yang diambil berupa aktivitas dan hasil belajar siswa. Pencapaian ketuntasan belajar sebesar 93,94% dan aktivitas siswa yang tergolong tinggi dan sangat tinggi dengan persentase sebesar 80,02%. Berdasarkan hasil penelitian disimpulkan bahwa pembelajaran dengan menggunakan model pembelajaran Creative Problem Solving pada materi sistem pernapasan di SMAN 1 Jatibarang Brebes dapat diterapkan karena terbukti efektif.