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All Journal AGRIVITA, Journal of Agricultural Science Berkala Kedokteran Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Pengabdian Masyarakat: Humanity and Medicine Berkala Penelitian Hayati Hang Tuah Medical Journal

Noer Kumala Indahsari, Noer Kumala

Department Of Biochemistry, Medical Faculty Of Medicine, University Of Wijaya Kusuma Surabaya, Indonesia

Author-ID : 615007

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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POTENTIAL EXTRACT OF Moringa Oleifera AS HEPATOPROTECTIVE IN WHITE RATS (Rattus novergicus) INDUCED TOXIC DOSES OF PARACETAMOL Indahsari, Noer Kumala; masfufatun, masfufatun; D.R, Emilia Devi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 5, No 1 (2016): Edisi Maret 2016
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Moringa Oleifera is a plant that contains chemical compounds that are useful, such as flavonoids. The ability of this flavonoid compound that can capture free radicals cause damage and hepatoprotektan hepar. Purpose of study was to determined levels of Moringa leaf extract which can overcome the effects of liver damage caused by toxic doses of paracetamol through MDA, SGOT and SGPT Method used in this laboratory experimental study is a Randomized Post Test Only Control Group Design with the following stages: 1. Moringa Leaf Extraction with Ethanol 96%; Try 2.Preparasi animals, 3. Treatment of Animals Try the extract of leaves of Moringa 3 dose is: 250mg / 200BB rat (dose of A), 500mg / 200BB mice (dose B), 1000mg / 200BB mice (dose C) for 14 days in combination with paracetamol 2 g / 200BB mice, compared to the negative control group (group given just paracetamol 2 g / 200BB rat) and the positive control group (the group who were given regular feed) for 14 days.Results : turned out to be no difference in the reduction in SGOT levels are statistically significant between the negative control group with high-dose treatment group ie the dose C with ï¡=0,016 smaller than 0.05, whereas a decrease in ALT levels were significantly decreased in the treatment group high dose is the dose C with ï¡=0,009 smaller than 0.05. While MDA group treated with the negative control group experienced an overall decline for the dose A with ï¡=0,05, dose B with ï¡=0,0011 and dose C with ï¡=0,001. Conclusion of this study showed that the extract of Moringa leaves can be potentially as an antioxidant in all doses at once can be as hepatoprotektor at high doses is 1000mg / 200BB Rattus Novergicus.

Characterization and Antioxidant Potential Albumin Protein of Canna striata Fish to Rattus Novergicus Induced by Isoniazid Toxic Dose Indahsari, Noer Kumala
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4536

Abstract: The Canna Striata fish is a potent source of albumin as an antioxidant. Albumin is a protein capable of binding to free radicals in plasma and has 17 disulfide bonds linking sulfur-containing amino acids. The existence of thiol group bonds in albumin extract of Canna Striata fish is possible to bind to diphenylphycril hydrazyl (DPPH), causing the antioxidant capacity of Canna Striata fish extract to be high. The accumulation of free radicals produced by the administration of antituberculosis drugs from the results of isoniazid metabolism can cause hepatic necrosis. So it requires antioxidants that can reduce free radical levels, which in this study was tested in white rats induced with isoniazid and then treated with albumin protein extract Canna Striata fish. This research method is the first experimental method done is the characterization of albumin protein extract Canna Striata fish with temperature 25ËC and 40ËC by Sodium Dodecyl Sulfate Polyacrilamide Gel Electrophoresis (SDS-PAGE). Then the antioxidant level was tested by measuring the levels of Malondialdehyde (MDA) after 2 last week treatment period in 5 groups of white rats are positive control group, negative control group and 3 treatment groups induced Isoniazid toxic dose are 37.8 mg accompanied by giving of albumin protein extract Canna Striata fish with content of 20ml/kg, 40 ml/kg and 60 ml/kg. The result of this study showed that there were ten albumin protein profiles with size 15,41 kDa, 19,74 kDa 28,6 kDa, 38,87 kDa, 46,08 kDa, 72,45 kDa, 94,42 kDa , 120.82 kDa, 142.80 kDa, and 155.97 kDa. Based on One Way ANOVA and Post Hoc Tukey statistic test, it were found that there was the significant influence and differentiation of Malondialdehyde (MDA) level on giving of albuminÂ protein extract in white rats induced by Isoniazid with p-value 0,002. The most effective decrease in MDA levels is high levels of albumin protein extract of 60 ml/kg.Â Keywords: Albumin Protein Extract of Canna Striata, Malondialdehyde, Isoniazid

Characterization and Antioxidant Potential Albumin Protein of Canna striata Fish to Rattus Novergicus Induced by Isoniazid Toxic Dose Noer Kumala Indahsari
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The Canna Striata fish is a potent source of albumin as an antioxidant. Albumin is a protein capable of binding to free radicals in plasma and has 17 disulfide bonds linking sulfur-containing amino acids. The existence of thiol group bonds in albumin extract of Canna Striata fish is possible to bind to diphenylphycril hydrazyl (DPPH), causing the antioxidant capacity of Canna Striata fish extract to be high. The accumulation of free radicals produced by the administration of antituberculosis drugs from the results of isoniazid metabolism can cause hepatic necrosis. So it requires antioxidants that can reduce free radical levels, which in this study was tested in white rats induced with isoniazid and then treated with albumin protein extract Canna Striata fish. This research method is the first experimental method done is the characterization of albumin protein extract Canna Striata fish with temperature 25˚C and 40˚C by Sodium Dodecyl Sulfate Polyacrilamide Gel Electrophoresis (SDS-PAGE). Then the antioxidant level was tested by measuring the levels of Malondialdehyde (MDA) after 2 last week treatment period in 5 groups of white rats are positive control group, negative control group and 3 treatment groups induced Isoniazid toxic dose are 37.8 mg accompanied by giving of albumin protein extract Canna Striata fish with content of 20ml/kg, 40 ml/kg and 60 ml/kg. The result of this study showed that there were ten albumin protein profiles with size 15,41 kDa, 19,74 kDa 28,6 kDa, 38,87 kDa, 46,08 kDa, 72,45 kDa, 94,42 kDa , 120.82 kDa, 142.80 kDa, and 155.97 kDa. Based on One Way ANOVA and Post Hoc Tukey statistic test, it were found that there was the significant influence and differentiation of Malondialdehyde (MDA) level on giving of albumin protein extract in white rats induced by Isoniazid with p-value 0,002. The most effective decrease in MDA levels is high levels of albumin protein extract of 60 ml/kg. Keywords: Albumin Protein Extract of Canna Striata, Malondialdehyde, Isoniazid

Potential of Pectin in Lemon’s and Bali Orange’s Peel as Antidislipidemia and Antioxidant in Hypercholesterolemia Rats (Rattus novergicus) Noer Kumala Indahsari; Aristanto Aristanto; Rio Rio
Berkala Kedokteran Vol 16, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Dyslipidemia is a lipid metabolism disorder characterized by an increase or decrease in plasma lipid fractions. Lemon’s and Bali Orange’s Peels, which are usually discarded, can be used because they contain pectin compounds. The presence of pectin compounds contained in the Lemon and Bali oranges Peels is expected to potentially reduce the risk factors for cardiovascular disease. This research method was conducted with pure experimental, namely One Group Pre-Test-Post Test Design. With 5 groups of white rats, the first was a positive control group which was only given normal food, the second was a negative control group which was given hypercholesterolemia and the third group was the treatment group who were given Lemon orange peel extract 10%, Bali orange peels extract 10% and a mixture Lemon and Bali orange peel extract 10%. The results of this study were obtained that the administration of Lemon orange peel ethanol extract and Balinese orange peel can effectively reduce total cholesterol levels, from 181.87 mg / dL to 69.29 mg / dL, down around 61.91%, HDL levels are almost the same, levels LDL decreased from 56.76 mg / dL to 45.71 mg / dl, meaning around 19.47%, Triglyceride levels decreased from 192.50 mg / dL to 77.83 mg / dL, which was around 59.57%, levels MDA decreased from 8.19 mg / dL to 6.37 mg / dL, which is down about 22.22% in white rats (Rattus novergicus) made hypercholesteroalmia. Ethanol extract of Lemon and Bali orangse peels containing pectin can effectively reduce total cholesterol, LDL, HDL, Trygliceryde, and Malodialdehyd (MDA) Levels Keywords: Hypercholesterolamia, Pectin, Antidislipidemia, and Antioxidant

Comparative Literature Study of Bligo Fruit Extract (Benincasa hispida (Thunb) Cogn) and Bitter Melon (Momordica charantia L.) Extract on the Minimum Inhibition of Salmonella typhi Bacteria Mei Rizqi Putri Afifah; Noer Kumala Indahsari
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Salmonella typhi is a gram-negative bacteria species that causes typhoid fever. Salmonella typhi is sensitive to antibiotics such as amoxicillin, chloramphenicol, ciprofloxacin, and cotrimoxazole. However, there has been some increase in antibiotic resistance, so there is a need for new antibacterials that do not have a resistance effect to treat infection. Bligo fruit (Benincasa hispida (Thunb) Cogn) and bitter melon (Momordica charantia L.) contain saponins, tannins, flavonoids, alkaloids, and triterpenoids which have antibacterial power. The purpose of this study was to compare the effectiveness of the bligo fruit extract (Benincasa hispida (Thunb) Cogn) and bitter melon extract (Momordica charantia L.) on the minimum inhibition of Salmonella typhi bacteria. The method used is narrative literature review. The results of the journal study showed that the extract of bitter melon (Momordica charantia L.) was more effective in inhibiting Salmonella typhi bacteria than the extract of bligo (Benincasa hispida (Thunb) Cogn) with a minimum inhibitory power at a concentration of 20%, namely 8.5 mm. Keywords: Bligo Fruit (Benincasa hispida (Thunb) Cogn), Bitter Melon (Momordica charantia L.), Salmonella typhi.

Effects of Curcumin on Stability and Efficacy of Neem Leaves Extract as Botanical Insecticides Elika Joeniarti; Masfufatun Masfufatun; Noer Kumala Indahsari; Endang Noerhartati
AGRIVITA, Journal of Agricultural Science Vol 42, No 2 (2020)
Publisher : Faculty of Agriculture University of Brawijaya in collaboration with PERAGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17503/agrivita.v42i2.2651

Botanical insecticides are considered biodegradable, environmentally compatible, and less toxic to non-target organisms than synthetic insecticides. Unfortunately, they are not attractive to Indonesian farmers due to its instability against light, temperature, and microbes, as well as they, have short storage time. This research was intended to produce a distinctive botanical insecticide that is resilient against the light, microbes, and durable. The role of curcumin in the stability and efficacy of neem (Azadirachta indica) leaves extract as a botanical insecticide against soybean pod sucking bug, Riptortus linearis was evaluated in the laboratory. This research was conducted at the Organic Chemistry Laboratory of Chemistry Department, Faculty of Science and Technology Airlangga University and the Plant Protection Laboratory, Faculty of Agriculture University of Wijaya Kusuma Surabaya, Indonesia, from March to October 2016. The results explained that curcumin is no effect on increase the stability of neem leaves extract solution towards UV light irradiation. However, it can increase the insecticide activity of neem leaves extract solution up to 96% mortality against soybean pod sucking bug, R. linearis. The increase of the bioactivity refers to the anti insecticidal activity of ferulic acid formed from the degradation of curcumin.

Antibacterial and antibiofilm effect of silver and gold nanoparticles in Uropathogenic Escherichia coli Rini Purbowati; Sugiharto; Agusniar Furkani Listyawati; Masfufatun; Lusiani Tjandra; Noer Kumala Indahsari
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 27 No 2 (2022): June 2022
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/bphjbr.27.2.20222

Nosocomial infections of the urinary tract are the most common nosocomial infections. Infectious diseases currently pose a life threatening due to the increasing phenomenon of infectious agent resistance. One of the factors known to cause resistance to broad-spectrum antimicrobials agent is the susceptibility to biofilm formation. The use of silver nanoparticles (NPs) is now regarded as one of the most promising strategies to target infections associated with biofilms. This study aims to determine the application of nanotechnology in the form of metal nanoparticles in targeting the formation of biofilms on infectious agents. The antibacterial and antibiofilm activity test was performed on a 96-well microtiter plate on uropathogenic Escherichia coli (UPEC) at concentrations of 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100 ppm. The results showed the addition of silver and gold nanoparticles at different concentrations affected and inhibited the growth of UPEC and prevented the formation of biofilms, as indicated by a decrease in the OD value. In conclusion, silver and gold nanoparticles have antibacterial and antibiofilm effects on UPEC.

Peningkatan pengetahuan “Pentingnya Perilaku Hidup Bersih dan Sehat” pada Posyandu Remaja Mojo Gubeng Surabaya Rini Purbowati; Ayly Soekanto; Febtarini Rahmawati; Lusiani Tjandra; Masfufatun; Emilia Devi Dwi Rianti; Noer Kumala Indahsari
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 3 No 1 (2022): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V3I1.72

Indonesia is currently facing a double burden of diseases, namely Communicable Diseases (PM) and Non-Communicable Diseases (NCD) which are strongly influenced by changes in the environment, community behavior, demographic transition, technology, economy, and socio-culture. To overcome this problem, the government has intensified the Program Perilaku Hidup Bersih dan Sehat (PHBS), which should involve all elements of society, stakeholders, the private sector, academia, and non-governmental organization (NGOs) and other sectors. The role of young people is needed by the government in the process of sustainable development or the Sustainable Development Goals (SDGs). The purpose of this activity is to increase public knowledge and awareness, especially among members of the Youth Posyandu Mojo Gubeng Surabaya about the importance of clean and healthy living behavior. This service activity was carried out on Saturday 11 September 2021, attended by 26 participants. This community service activity was chosen in the form of an online seminar (webinar) to support the government in handling COVID-19 by implementing Emergency PPKM. Measurement of the increase in participants' knowledge was carried out through pre-test and post-test by answering questions related to the webinar material by filling out Google Forms. The measurement results obtained a pre-test average and post-test average value (82.1±18) with a delta value (change in score) of 18.6. Community Service Activities through a Webinar with the title "The Importance of Healthy Lifestyle Behavior at the Youth Posyandu Mojo Gubeng Surabaya" can increase public knowledge at the Mojo Youth Posyandu Surabaya.

Hubungan Antara Kebiasaan Aktivitas Fisik dengan Indeks Massa Tubuh (Imt) pada Mahasiswa Fk-Uwks Angkatan 2016 dan 2017 NOER KUMALA INDAHSARI; MOCH. IRFAN MAHALI
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract Background: Being overweight in a person increases the risk of developing degenerative diseases, including diabetes mellitus which is still the most common cause of death, thus maintaining a normal weight allows a person to reach a longer life expectancy. One of the activities that can make normal weight is physical activity. The Body Mass Index (BMI) is a simple, inexpensive and easy method of assessing a person's nutritional status, but BMI can’t measure body fat directly. So that in this study activities will be carried out to get a relationship between physical activity with BMI for FK-UWKS students 2016-2017. Methode: 124 respondents from the 2016 and 2017 FK-UWKS students and taken randomly. The research method used was an analytic observational study with a cross sectional study. Data taken includes BMI, and physical activity. Statistical test with Spearman correlation test (x2). In the early stages of the study anthropometric measurements were carried out to determine Student BMI. Physical activity is measured by recalling activities that students do every day. Results: groups that always carried out physical activity were 24 respondents who had a normal body mass index, while the group that had never carried out physical activity had 57 respondents with a body mass index with details (3 respondents with less BMI, 11 respondents with normal BMI, 30 respondents with excessive BMI and 13 respondents with Obesity BMI)as well as groups that sometimes carried out physical activities totaling 43 respondents had a relatively normal body mass index. Conclution: There is a relationship between physical activity and the Body Mass Index in the 2016 and 2017 FK-UWKS students

Correlation of Weaning Food with the Event of Stunting to Toddlers in Kali Rungkut Village Surabaya Warini Ayu Safitri; Noer Kumala Indahsari
Berkala Kedokteran Vol 18, No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v18i2.14496

Stunting is a chronic nutritional problem due to several factors and is intergenerational. For the number of children with stunting conditions, Indonesia is ranked fifth globally. This is due to one of the reasons for the provision of less nutritious food during the growth period obtained from weaning food. The purpose of this study was to determine whether there was a relationship between the provision of weaning food and the incidence of stunting in children in Kali Rungkut Village, Surabaya.This study is a case control method of chi square analysis and kappa correlation using primary data, namely questionnaires. The number of samples that meet the criteria are 53 people, then the data is processed with SPSS.Based on the results of the study, the relationship between complementary feeding and the incidence of stunting in Toddlers in Kali Rungkut Village, Surabaya, with a p-value of 0.002 less than (0.05) and an OR of 6.429. Based on the results of the study, it can be concluded that there is a significant relationship between the provision of complementary foods and the incidence of stunting in children under five in Kalirungkut sub-district, Surabaya and the relationship between the provision of complementary foods and the incidence of stunting is a large category, which has a risk of 6,429 times greater in the provision of complementary foods, less good in the incidence of stunting than the provision of complementary foods. the good one.

Co-Authors Agusniar Furkani Listyawati Aristanto Aristanto Ayly Soekanto Emilia Devi D.R, Emilia Devi Emilia Devi Dwi Rianti Febtarini Rahmawati Joeniarti, Elika Lusiani Tjandra Masfufatun Masfufatun Mei Rizqi Putri Afifah MOCH. IRFAN MAHALI PRIMA WIBISONO Rini Purbowati, Rini Rio Rio Sugiharto Warini Ayu Safitri

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