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All Journal Jurnal Kesehatan Reproduksi Universa Medicina Promotif: Jurnal Kesehatan Masyarakat Jurnal Biomedika dan Kesehatan
Raditya Wratsangka, Raditya
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Psychosocial aspect determines quality of life in postmenopausal women Wratsangka, Raditya
Universa Medicina Vol 29, No 1 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.34-45

Abstract

The postmenopausal period plays an important role in women’s life and gives rise to many physical and mental problems. A cross-sectional was conducted to determine the quality of life and its determinants, namely pyschosocial and lifestyle factors in postmenopausal women. One hundred and seventy-six postmenopausal women meeting the inclusion criteria were recruited. The            menopause rating scale (MRS) questionnaire was used for the assessment of quality of life. One hundred and thirty-one (74.4%) subjects had complaints related to menopausal symptoms in 3 degrees of severity: mild (38.6%), moderate (30.7%) and severe (5.1%). Urogenital symptoms were the most frequent       complaints reported by the subjects (71.6%). The correlation between quality of life of   postmenopausal women and several psychosocial and lifestyle factors, namely marital status, education, occupation, knowledge and attitude towards menopause, exercise, smoking and consumption of caffeine and alcohol was statistically not significant (p>0.05). By multiple logistic regression analysis, some of the determinants, such as the subjects’ attitude towards menopause (PR = 2.863; 95% CI: 0.578 – 14.185) and support from the husband and/or family (PR = 2.124; 95% CI: 0.979 – 4.610) did not reach statistical significance, but were still the most influencing factors on their quality of life. Quality of life is worst in postmenopausal women and therefore counseling and support from husband and/or family are needed by the postmenopausal women in order to improve their quality of life.
Soy isoflavone supplementation tends to improve specific immune responses in postmenopausal women Wratsangka, Raditya
Universa Medicina Vol 30, No 3 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.162-172

Abstract

Immune dysfunction in postmenopausal women tends to decrease health-related quality of life (HRQoL). The present study’s objective was to evaluate the effect of daily supplementation of 100 mg soy isoflavones on specific immune responses among healthy postmenopausal women. The study design was a community-based double blind randomized controlled trial involving 60 healthy postmenopausal women, aged between 48–60 years, in the Mampang Prapatan district of South Jakarta. Participants were randomized to receive either 100 mg soy-isoflavone + 500 mg calcium (intervention group) or 500 mg calcium only (control group). Both supplements were taken daily for 12 weeks, from January to April 2010. Specific immune responses (measured by serum Ig G and CD4+) were assessed at baseline and after supplementation. Statistical analysis using independent t-test was performed to evaluate the effect of soy isoflavone supplementation on specific immune responses. Fifty-six (93.3%) participants completed the study without any significant side-effects or adverse events. Daily supplementation of 100 mg soy isoflavones for 12 weeks did not significantly increase the humoral specific immune response (p=0.242), but tended to improve the cellular specific immune response (p= 0.850). Other findings of this study were that soy isoflavone supplementation tends to improve specific immune responses in postmenopausal women with normal body mass index and adequate daily dietary isoflavone intakes. Short-term soy isoflavone supplementation is unable to improve the humoral and cellular specific immune responses in postmenopausal women aged 48 to 60 years.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEHAMILAN TIDAK DIINGINKAN DI INDONESIA Anggraini, Kirana; Wratsangka, Raditya; Bantas, Krisnawati; Fikawati, Sandra
PROMOTIF: Jurnal Kesehatan Masyarakat Vol 8, No 1 (2018): PROMOTIF - JUNI
Publisher : PROMOTIF: Jurnal Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1247.595 KB) | DOI: 10.31934/promotif.v8i1.227

Abstract

Kehamilan tidak diinginkan merupakan masalah global, dan menyumbang 700.000 kematian ibu setiap tahunnya.  Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kehamilan tidak diinginkan di  Indonesia. Desain studi adalah potong lintang, dengan responden sebanyak 13.955 perempuan berusia 15-49 tahun, yang melahirkan anak terakhir dalam 5 tahun sebelum survei. Penelitian ini menggunakan data sekunder, dari Survei Demografi Kesehatan Indonesia (SDKI) tahun 2012.  Uji analisis yang digunakan adalah uji kai kuadrat (bivariat) dan regresi logistik ganda (multivariat).  Hasil studi menunjukkan prevalensi ibu yang mengalami kehamilan tidak diinginkan di Indonesia sebanyak 8%, dengan prevalensi tertinggi terdapat di provinsi Sulawesi Tengah (11,9%) dan terendah di  Papua (2.9%).  Pada analisis bivariat didapatkan hubungan yang bermakna antara tingkat ekonomi, tingkat pendidikan, wilayah tempat tinggal, status pernikahan, paritas, jarak kelahiran, usia dengan kehamilan tidak diinginkan dengan nilai p< 0,25.  Pada analisis multivariat, variabel status pernikahan berhubungan signifikan dengan kehamilan tidak diinginkan setelah dikontrol dengan variabel tingkat ekonomi, tingkat pendidikan, wilayah tempat tinggal, paritas, jarak kelahiran dan usia.  Disimpulkan faktor status pernikahan merupakan faktor paling dominan yang berhubungan dengan kehamilan tidak diinginkan. Penemuan ini diharapkan dapat menjadi masukan bagi pemerintah untuk meningkatkan pengetahuan dan partisipasi masyarakat tentang program Keluarga Berencana. 
KESEHATAN REPRODUKSI MAHASISWA : KEBUTUHAN INFORMASI DAN PELAYANAN Studi Kualitatif di Jakarta Barat Wratsangka, Raditya
JURNAL KESEHATAN REPRODUKSI Vol 2, No 2 (2015)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.933 KB) | DOI: 10.22146/jkr.12644

Abstract

KESEHATAN REPRODUKSI MAHASISWA : KEBUTUHANINFORMASI DAN PELAYANANStudi Kualitatif di Jakarta BaratRaditya Wratsangka1ABSTRACTBackground: Young people comprise students are a considerably large segment of the world populationwith important future roles, who face reproductive health-associated risks, such as sexually transmitteddiseases, HIV/AIDS, sexual violence, unwanted pregnancy, and unsafe abortion. They are less informed,less experienced, and less comfortable in accessing reproductive health services and even face resistancefrom adults when attempting to do so.Objective: To assess the reproductive health information, types, access and models of services requiredby students.Method: This was a qualitative study involving students from three universities in West Jakarta. Datacollection was by focus group discussion and indepth interviews. Data were validated by triangulation ofinformation sources and method. Data analysis was performed by content analysis method to extract theroot of the problem.Result and Discussion: Fourteen unmarried students were involved as informants/respondents. Severalhad inadequate knowledge of reproductive health and difficulties in accessing appropriate informationsources, so that they engaged in risky behavior for various reasons. The informants expressed their needfor reliable information, accessible and friendly professional counselling and clinical reproductive healthservices, and also that guarantee their privacy.Conclusion: Information, counselling and clinical services should be instituted that meet the requirementsof students for improving their reproductive health.Key words: reproductive health, information, counselling, servicesABSTRAKLatar Belakang: Kaum muda -termasuk mahasiswa- dengan populasi yang besar dan peran yang penting dimasa depan, menghadapi berbagai risiko yang berkaitan dengan kesehatan reproduksinya, seperti: infeksimenular seksual, HIV/AIDS, kekerasan seksual, kehamilan yang tidak diinginkan dan aborsi yang tidakaman. Selama ini kaum muda kurang mendapatkan informasi, kurang berpengalaman, dan kurang nyamanmengakses pelayanan kesehatan reproduksi, bahkan mendapat tentangan dari kelompok dewasa, ketikamereka mencoba untuk memperoleh informasi dan pelayanan kesehatan reproduksi yang dibutuhkan.Tujuan: Mendapatkan gambaran tentang informasi, jenis, akses dan model pelayanan kesehatan reproduksiyang dibutuhkan oleh mahasiswa.Metode: Penelitian ini merupakan studi kualitatif dengan melibatkan mahasiswa dari 3 Universitas diJakarta Barat. Pengumpulan data dilakukan dengan teknik diskusi kelompok terarah dan wawancara mendalam. Validasi data dilakukan dengan teknik triangulasi sumber informasi dan metode. Analisis datadilakukan dengan content analysis method untuk menggali akar permasalahan.Hasil dan Pembahasan: Sebanyak 14 mahasiswa dilibatkan sebagai informan/responden yang semuanyabelum menikah. Sebagian informan kurang pengetahuannya di bidang kesehatan reproduksi, mengalamikesulitan mengakses informasi dan sumber yang tepat, sehingga terlibat dalam perilaku berisiko. Parainforman umumnya menyatakan kebutuhannya terhadap pelayanan konseling dan klinis kesehatanreproduksi yang profesional, mudah diakses, ramah dan tetap bisa menjaga privacy mereka.Kesimpulan: Dibutuhkan pelayanan informasi, konseling dan klinis yang sesuai kebutuhan mahasiswauntuk meningkatkan kesehatan reproduksinya.Kata kunci: kesehatan reproduksi, informasi, konseling, pelayanan1 Bagian Obstetri dan Ginekologi - Fakultas Kedokteran Universitas Trisakti /Pusat Konseling, Informasi dan Edukasi Kesehatan Reproduksi Universitas Trisakti
The importance of anemia and health-related quality of life in the elderly Wratsangka, Raditya; Putri, Rully Ayu Nirmalasari Haryadi
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.135-149

Abstract

Anemia is a global health problem with an extremely high prevalence and occurring in nearly 25% of the world population, particularly in the elderly group. Currently Indonesia is facing a rapid growth of the elderly population, with around 21 million elderly (8.2% of the total population), that is projected to increase to 33.7 million (11.8%) in the year 2025. Anemia in the elderly is frequently neglected, although the facts show that low hemoglobin concentration is an important marker of physiological decline and functional limitations. Although the factor of intrinsic aging may cause low hemoglobin concentration, anemia in the elderly is known to have a wide range w88ith regard to etiology, underlying disorders, and  possible mechanisms, such that it should be clinically followed up. Whatever its causes or underlying pathophysiological, anemia in the elderly has been proven to play a role in their morbidity and mortality, and may decrease their quality of life, that comprises all aspects of physical, mental, and social health, known as health-related quality of life (HRQoL). The impact of anemia on HRQoL has been studied in various populations, and most studies report the presence of an association between HRQoL and anemia in elderly individuals, which on the subscale level is particularly associated with physical health. Early diagnosis of anemia is important to prevent aggravation of the condition, to retard the progress of the disease, and to improve the health-related quality of life (HRQoL) of the patient. Prior to determining the treatment plan, the primary diagnosis and the comorbidities, especially treatable disorders, had better be identified first. The available data show that the overall prognosis will improve for anemia in patients with well-managed and corrected chronic disorders.
Kejadian bayi berat lahir rendah berhubungan dengan ibu hamil bersuamikan perokok aktif Pratama, Gustian Satria; Wratsangka, Raditya
Jurnal Biomedika dan Kesehatan Vol 1 No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2018.v1.133-139

Abstract

LATAR BELAKANGBayi Berat Lahir Rendah (BBLR) merupakan salah satu penyebab tingginya angka kematian perinatal dan neonatal. Prevalensi BBLR di seluruh dunia mencapai 15% dari seluruh kelahiran, dan > 97% di antaranya terjadi di negara berkembang. Perilaku negatif selama kehamilan seperti paparan asap rokok dapat menurunkan perfusi plasenta sehingga menurunkan penerimaan O2 bagi janin, yang akan meningkatkan risiko kelahiran BBLR. Paparan asap pembakaran tembakau juga menurunkan 20% kadar asam folat di dalam tubuh yang menyebabkan terganggunya pertumbuhan janin di dalam rahim. Penelitian ini bertujuan untuk mengetahui hubungan antara paparan asap rokok pada ibu hamil yang bersuamikan perokok aktif dan kejadian BBLR. METODEPenelitian dengan disain observasional analitik dan pendekatan potong-lintang untuk mengetahui hubungan antara ibu hamil bersuamikan perokok aktif (variabel bebas) dan kejadian BBLR (variabel tergantung). Populasi terjangkau adalah ibu hamil yang melahirkan di RSUD Karawang pada bulan Januari sampai Agustus 2017, dan pengambilan sampel dilakukan secara acak sederhana. Data penelitian ini merupakan data primer dan sekunder, yaitu berupa data kuesioner yang didapat dari ibu hamil bersuamikan perokok aktif dan rekam medik untuk data bayi BBLR. Pengolahan dan analisis data menggunakan Statistical Package for Social Sciences (SPSS), dan uji chi square dengan derajat kepercayaan (CI) 95% dan batas kemaknaan 0,05. HASILSubyek penelitian berjumlah 132 orang, dan terdapat 96 bayi (73%) dengan kasus BBLR. Terdapat hubungan bermakna antara ibu hamil bersuamikan perokok aktif dan kejadian BBLR (p = 0.000 (p ≤ 0,05)). KESIMPULANTerdapat hubungan antara ibu hamil bersuamikan perokok aktif dan kejadian BBLR.
Hubungan antara ekspresi vascular endothelial growth factor (VEGF) jaringan dengan respon kemoradiasi pada pasien kanker serviks Mayasari, Atut Cicih; Wratsangka, Raditya
Jurnal Biomedika dan Kesehatan Vol 3 No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

LATAR BELAKANGKanker serviks masih merupakan masalah keganasan utama yang dihadapi wanita seluruh dunia. Tidak adanya gejala pada penderita kanker serviks stadium awal, sering menyebabkan keterlambatan dalam diagnosis. Vascular endothelial growth factor (VEGF) merupakan salah satu faktor yang berperan penting dalam proses angiogenesis dan merupakan sinyal yang digunakan oleh sel kekurangan oksigen untuk memicu pertumbuhan pembuluh darah. Penelitian ini bertujuan membandingkan respon klinik kemoradiasi pada pasien kanker serviks yang mempunyai ekspresi VEGF tinggi, sedang dan rendah. METODEPenelitian ini menggunakan rancangan studi kasus kontrol untuk mencari hubungan antara ekspresi VEGF dengan respon kemoradiasi pada penderita kanker serviks. Sebagai kelompok kasus adalah pasien dengan respon terapi parsial dan kelompok kontrol adalah pasien dengan respon terapi komplit. Empat puluh lima pasien, masing-masing terdiri dari 15 pasien kelompok kasus dan 30 pasien kelompok kontrol. Data sekunder diambil dari rekam medis RS Cipto Mangunkusumo Jakarta. Dilakukan penelusuran blok parafin ke bagian Patologi Anatomi RS Cipto Mangunkusumo Jakarta. Pemeriksaan ekspresi VEGF dilakukan terhadap jaringan biopsi kanker serviks sebelum kemoterapi. HASILPada faktor risiko umur, didapatkan nilai p=0.18 dan OR 0.37. Maka tidak ada hubungan yang bermakna secara statistik, namun secara klinik mempunyai nilai protektif lemah. Pada analisa lebih lanjut hanya didapatkan 2 pasien usia ≥ 50 tahun yang mempunyai ekspresi VEGF kuat. Pada faktor risiko stadium, diferensiasi sel, dan body mass index (BMI) berturut-turut mempunyai nilai p 1; 0.46 dan 1, sedangkan nilai OR 1; 2 dan 1, maka tidak bermakana secara statistik dan klinik. Jenis histologi nilai p 0.19 dan OR 3.27 secara statistik tidak bermakna namun secara klinik bermakna. Ekspresi VEGF mempunyai nilai p 0.03 dan OR 0.45 jadi secara statistik dan klinik bermakna. Setelah dilakukan analisis multi variat maka yang mempunyai hubungan paling bermakna secara statistik dan klinik dengan respon terapi adalah ekspresi VEGF. KESIMPULANEkspresi VEGF yang kuat akan memberikan respon terapi/outcome yang buruk.
Mandatory universal use of cloth mask for prevention of coronavirus disease 2019 transmission Yenny, Yenny; Herwana, Elly; Wratsangka, Raditya
Universa Medicina Vol. 40 No. 1 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.57-68

Abstract

Since the outbreak in Wuhan City, China, in late December 2019, the Coronavirus Disease 2019 (COVID-19) has spread to nearly the whole world, so that it was declared a pandemic by the Word Health Organization. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative organism of COVID-19, is extremely infectious and can adhere to droplet nuclei of < 5 mm diameter and become airborne (aerosol). Since COVID-19 was declared a pandemic, there has been controversy on the use of cloth masks by the public, because of the still inconclusive evidence of the efficacy of cloth masks in protecting against COVID-19 transmission. Universal masking as a healthcare intervention in the community is currently made mandatory by local governments of most countries, since they follow the recent recommendation by the World Health Organization. The issuing of the WHO recommendation on the public use of masks was based on a study demonstrating that COVID-19 transmission does not occur only through droplets but also through aerosols. In addition, there was a study showing that COVID-19 transmission does not only occur from patients with clinical symptoms but also through asymptomatic and pre-symptomatic subjects, so that universal masking is of benefit in providing protection when used by healthy people and as source control to prevent cross-transmission to other people. This review article aims to discuss the mechanism of COVID-19 transmission, the evidence related to the efficacy of cloth masks, and the guidelines related to the selection and use of masks by the general population.
Co-Authors Anggraini, Kirana Atut Cicih Mayasari, Atut Cicih Elly Herwana, Elly Krisnawati Bantas Pratama, Gustian Satria Putri, Rully Ayu Nirmalasari Haryadi Sandra Fikawati YENNY YENNY