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All Journal Universa Medicina Cermin Dunia Kedokteran
Rosa De Lima Renita Sanyasi, Rosa De Lima Renita
Puskesmas Panekan RSAU dr. Efram Harsana
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Complications as important predictors of disability in ischemic stroke Pinzon, Rizaldy Taslim; Sanyasi, Rosa De Lima Renita
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.197-204

Abstract

BackgroundStroke is the main cause of disability and death in many countries. The high incidence of disability in stroke survivors requires special attention to determine various predictive factors of disability. This study aimed to identify the various predictive factors of disability in ischemic stroke.MethodsThis study was a cross sectional study on 4510 ischemic stroke patients. Each patient’s data had been recorded in the electronic stroke registry of Bethesda Hospital. Ischemic stroke diagnosis was confirmed by brain CT scan, which was interpreted by a neurologist and a radiologist. Disability was assessed using the modified Rankin scale. Predictors of disability were assessed. Multiple logistic regression analysis was used to analyse the data. ResultsThe subjects were predominantly males, >60 years of age, and suffered stroke for the first time. The incidence of disability was 31.5% (1420/4510). Multiple logistic regression analysis showed that the presence of complications (OR: 6.43; 95% CI: 4.74-8.73; p<0.001), decreased level of consciousness (OR: 4.82; 95% CI: 3.95-5.90; p <0.001), onset ³3 hours (OR: 1.93; 95% CI: 1.52-2.45; p<0.001), recurrent stroke (OR: 1.63; 95% CI: 1.39-1.90; p<0.001), and age >60 years (OR: 1.55; 95% CI: 1.35-1.79; p<0.001) were independent predictive factors of disability.ConclusionWe demonstrated that a substantial proportion of patients with ischemic stroke become disabled. And the presence of complications was the most predictive factor of disability in ischemic stroke.
Peran Channelopathy pada Tatalaksana Nyeri Meliala, Lucas; Pinzon, Rizaldy Taslim; Sanyasi, Rosa De Lima Renita
Cermin Dunia Kedokteran Vol 44, No 12 (2017): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.067 KB) | DOI: 10.55175/cdk.v44i12.689

Abstract

Latar Belakang: Tata laksana nyeri yang efektif sampai saat ini masih belum memuaskan. Pemahaman channelopathy diharapkan dapat meningkatkan kualitas penanganan nyeri. Tujuan: Kajian peran channelopathy pada nyeri. Pembahasan: Kanal ion yang terlibat dalam channelopathy pada nyeri adalah kanal natrium, kalsium, kalium, dan transient receptor potential (TRP). Channelopathy beberapa subtipe kanal TRP memicu penyakit FEPS tipe I dan berbagai gangguan sensitivitas nyeri. Channelopathy beberapa subtipe kanal kalsium dan kalium menimbulkan berbagai gangguan sensitivitas nyeri. Channelopathy kanal klorida tidak memicu gangguan sensitifitas nyeri. Saat ini telah ditemukan berbagai obat yang bekerja sebagai penghambat kerja kanal, sehingga dapat digunakan untuk terapi nyeri. Penelitian masih terus dilakukan hingga saat ini.Background: Treatment of pain remains challenging. Understanding channelopathy will hopefully improve pain treatment. Objective: To identify the role of channelopathy in pain mechanism. Discussion: Ion channels involved in channelopathy i.e: sodium channels, calcium channel, potassium channel, and transient receptor potential (TRP) channel. Channelopathy on some sodium channel subtypes lead to various diseases. Channelopathy on some TRP channels lead to FEPS type I and pain sensitivity disorder. Channelopathy on calcium and potassium channels lead to many pain sensitivity disorder. Channelopathy on chloride channels do not lead to pain sensitivity disorder. Many channels blocker drugs have been discovered. Knowledge of channelopathies will improve the quality of pain treatment.
Co-Authors Lucas Meliala Rizaldy Pinzon