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Strategi Mempertahankan Keunggulan Kompetitif PT Jayamandiri Gemasejati - Sukabumi Mansur, Umar; Zulfikri, Agung
Jurnal Bisnisman : Riset Bisnis dan Manajemen Vol 2 No 2 (2020): Jurnal Bisnisman : Riset Bisnis dan Manajemen
Publisher : Universitas Nusa Putra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52005/bisnisman.v2i2.31

Abstract

Jayamandiri Gemasejati is a company engaged in the Yamaha Motor and Spare Parts Sales Industry. This study aims to describe how the method used in this study is a descriptive method using a descriptive approach. Analysis of research data was carried out by identifying various internal and external factors through PT Jayamandiri Gemasejati's IFE, EFE, and SWOT matrix analysis. The identification and mapping of the key factors of the IFE and EFE matrices indicate that PT Jayamandiri Gemasejati is in a strong position and can well take advantage of opportunities and deal with existing threats with the strength they have, where Total IFE shows 2.69 and Total EFE shows 3,22 which indicates a strong internal and external position.
Analisis Glimepirida Dalam Plasma Tikus Harahap, Yahdiana; Mansur, Umar; Sinandang, Theresia
Majalah Ilmu Kefarmasian
Publisher : UI Scholars Hub

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Abstract

The aim of this research is to find the method for analyze glimepiride and itÂ’s metabolite. Glimepiride is the second generation of antidiabetic oral from the sulphonyl urea that works by stimulating the insulin secretion from beta cells of pancreas. Glimepiride is isolated from plasma the using chloroform. Using the high performance liquid chromatography method which include C18 reversed phase column, using mixture of methanol:water (50:50, v/v) as a mobile phase, flow rate 1.0 ml/minutes, detection at wavelenght 228 nm with photo diode array detector gives retention times of glimepiride in 17 minutes without any interference from endogen component of plasma and from itÂ’s metabolite. Linearity with added internal standard gliclazide was established for the range concentration 100-1000 ng/ml with coefficient of correlation (r) is 0.9977 and give the limit of quantitation of glimepiride in 50 ng/ml. The results of validation method fulfilled for the given criterias.
Determination of Ethanol In Employee's Blood Who Work In "X" Alcoholic Beverage Industry Using 1-Propanol as an Internal Standard by Gas Chromatography Harmita, Harmita; Mansur, Umar; Rahmadani, Suchi
Majalah Ilmu Kefarmasian Vol. 4, No. 3
Publisher : UI Scholars Hub

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Abstract

Ethanol not only caused drunk, but also in certain amount it can caused death. Because of the side effect of ethanol was dangerous if there sufficient concentration in blood and the penetration which is relatively easy so it was important to know how much ethanol in blood, especially on official employee in alcoholic beverage industry. A gas chromatography method using a capillary column CBP-10 and flame ionization detector (FID) has been developed and validated for the detection and quatification of ethanol in blood. Gas chromatography was performed in isothermal mode with column temperature 60oC. Helium was used as carrier gas with flow rate 1.0 mL/min. Quantification was performed with the uses of 1-propanol as an internal standard (IS). The method was linear in the concentration range of 0.001-0.8% v/v with coefficient of corelation 0.9998. The lower limit of quantification (LLOQ) was found to be 0.001% v/v. This method was validated with precisions (CV) 0.53-3.47% and accuracies (% diff) 3.86-7.46%. Result of ethanol recovery varied from 96.14-107.46%. The result of validation method fulfilled for the given criteria.
Validasi Metode Analisis Cilostazol Dalam Plasma In Vitro Secara Kromatografi Cair Kinerja Tinggi Harahap, Yahdiana; Mansur, Umar; Estherina, Christine
Majalah Ilmu Kefarmasian Vol. 5, No. 1
Publisher : UI Scholars Hub

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Abstract

Cilostazol is an antiplatelet agent with the mechanism of action by inhibiting phos-phodiesterase III (PDE III). Referred to Food and Drug Administration(FDA),cilostazol is a drug recommended to be bioequivalence (BE) studied. A high-perfor-mance liquid chromatographic (HPLC) method with ultraviolet detector for in vitro determination of cilostazol in human plasma had been developed and validated. Cilostazol and pioglitazone as internal standard were extracted from human plasma by protein precipitation method using methanol. The mobile phase consisting of ac-etonitrile-potassium di-hydrogen phosphate buffer 50 mM (40:60) was used at the flow rate of 1.5 mL/min on reversed phase C18 column (SunfireTM, 5 µm, 250x4.6 mm), and was detected at wavelength of 257 nm. Linearity was established within concentration range of 20-2000 ng/mL with coefficient correlation (r) was 0,9999. Accuracy (% diff) of this method was -14.67% up to 8.84% with precision (CV) being 0.98% to 4.93%, and absolute recovery was established to be 82.26% to 119.85%. Cilostazol in plasma was stable for 30 days in -200C storage.
Metode Penetapan Kadar Meloxicam Dalam Darah Manusia In Vitro Secara Kromatografi Cair Kinerja Tinggi Harmita, Harmita; Mansur, Umar; Firnando, Firnando
Majalah Ilmu Kefarmasian Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Until nowadays study of drug profile inside body (pharmacokinetic) and its development is still an interesting topic under pharmaceutical service. Development of an accurate analysis method for small quantity of drug in blood is an important step, HPLC method usually recommended for this purpose. Observation in studying the optimal method to analyze drug in human blood by using internal standard has been done for meloxicam, a new generation of NSAID. Two things has been focused to this observation, finding an ideal internal standard for meloxicam and testing the recovery of meloxicam in blood sample by in vitro. Coefficient of distribution of many samples (piroxicam, trimetropim, caffeine, salisilamid) gives caffeine as recommended internal standard for meloxicam. The recovery test gives 83,58% ± 3,802%, 74,37% ± 0,711%, 82,14% ± 1,937% for analysis meloxicam in human blood without internal standard; and 41,58% ± 1,108%, 61,60% ± 1,049%, 56,88% ± 0,478% for analysis meloxicam in human blood within internal standard.