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All Journal As-syifaa Jurnal Farmasi
Sitti Rahimah, Sitti
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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UJI AKTIVITAS EKSTRAK BIJI SELASIH (Ocimum basilicum L.) DENGAN BEBERAPA PELARUT SEBAGAI ANTIPIRETIK PADA MENCIT (Mus musculus) Rahimah, Sitti; hendrarti, Wahyu; Ramlah, Sitti
Jurnal Ilmiah As-Syifaa Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.534 KB) | DOI: 10.33096/jifa.v7i2.7

Abstract

Seeds basil (Ocimum basilicum L.) has been known to the publicand is widely used to treat a variety of diseases. One of its benefits as lowering fever but have not been proven scientifically. This study was to determine whether there is an antipyretic effecte basil seeds (Ocimum basilicum L.) and to determine the effectiveness of extracts of basil seeds by using some of the solvent is n-hexane, ethyl acetate and ethanol compared with paracetamol in mice (Mus musculus). This study was an experimental study using RAL. Experimental animals used were 15 mice, stages of research giving treatment af mice in each group who had fasted for 12 hours, measured rectal temperature (initial temperature), then injected with 1 ml peptone/tail subcutaneously. The data obtained were analyzed ANOVA followed BNJ test. Test antipyretic extract basil seeds (Ocimum basilicum) with some solvent, most effectively used as a solvent in the basil seeds that solvent ethyl acetate compared with solvent n-hexane and ethanol. The results oft his study showed that the extract of basil seeds antipyretic effect.
UJI TOKSISITAS TERATOGENIK EKSTRAK ETANOL DAUN ASAM JAWA (Tamarindus indica Linn) TERHADAP TIKUS (Rattus norvegicus) Rahimah, Sitti; Salampe, Mirnawati; Rahmania, Nurbaiti
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.058 KB) | DOI: 10.33096/jifa.v12i1.588

Abstract

In this study of teratogenic toxicity tests was carried out on the ethanol extract of tamarindus leaves (Tamarindus Indica Linn) on rats (Rattus norvegicus) during the organogenesis period. This study aims to know the safety and toxicity of the administration of ethanol extract of tamarind leaves (Tamarindus indica L.) to fetus rats (Rattus norvegicus) with macroscopic parameters including number, resorption, weight, and skeleton of the fetus. 15 animals were divided into 3 groups, each group consisted of 5 rats. Group I was treated with 0.5% Na CMC as normal control,  group II was treated with ethanol extract of tamarind leaves with a dose of 14 mg / 200 g BW for 10 days and group III was given a simvastatin tab at a dose of 10 mg / kg BW. Treatment was given orally during the organogenesis period on the 5th to 15th day of pregnancy. On the 16th day, laparatomy of the rat and fetus was removed from the uterus. The results showed that the suspension of ethanolic extract of tamarind leaves did not cause teratogenic occurrence in fetal rats, and the control of simvastatin caused teratogenic due to resorption, less fetal weight, hand and foot defect, and death in the fetus, compared to the normal control group.
Co-Authors Rahmania, Nurbaiti Salampe, Mirnawati Sitti Ramlah Wahyu Hendrarti