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All Journal As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan
Irma Santi, Irma
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Nefroterapi Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile) Dengan Parameter Ureum Tikus Putih Jantan yang Diinduksi Gentamisin Azizah, Rizqi Nur; Santi, Irma; Marlian, Ayu
Window of Health : Jurnal Kesehatan Vol. 2 No. 2 (April, 2019)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.191 KB) | DOI: 10.33368/woh.v0i0.166

Abstract

African leaves (Vernonia amygdalina Delile.) contain flavonoids having an antioxidant activities. The research aimed to determine the nephrotherapy effect of the ethanolic extract of African leaves with the parameter of male rat urea (Rattus norvegicus) induced by gentamicin. The research used 18 rats divided into 6 groups consisting of group I as the normal group, group Il the Negative Control (gentamicin 80 mg I kgBW), group Ill the Positive Contfol (amino acid supplement), group IV, V, and VI given the ethanol extract of African leaves, each dose of 100 mg/kgBW, 250 mg/kgBW, 500 mg/kgBW. The induction of gentamicin 80 mg/kg BW was administered for eight days and the therapy for the ethanol extract of African leaves for fourteen days. The research data were statistically analyzed using the ANOVA test followed by the Post Hoc LSD test. The results showed that the ethanol extract of African leaves had the nephrotherapy effects in reducing the urea in male rat induced by gentamicin.
STUDI PENGGUNAAN OBAT DIARE PADA ANAK PASIEN RAWAT INAP DI RSUD ANDI DJEMMA MASAMBA KABUPATEN LUWU UTARA PERIODE JANUARI-DESEMBER 2014 Santi, Irma; Herman, Hendra; Aninditia, Dian Dwi
Jurnal Ilmiah As-Syifaa Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.108 KB) | DOI: 10.33096/jifa.v9i2.277

Abstract

Diarrhea is generally caused by the bacteria contamined in food and drink. If the bacteria are not the right treatment, it can be fatal and cause death. This research aimed to present the drug use on the diarrhea patient of hospitalized children ar RSUD Andi Djemma Masamba North Luwu district. This research used descriptive method  by collecting data retrospectively. The data were collected by searching the treatment  records given by doctors to diarrhea patient of hospitalized children. The data obtained included patient medical record number, sex, age, body temperature, therapy (drug name, dose, frequency, route of administration) and length of stay.  The result showed that the diarrhea drug use on children included antibiotic drugs(cotrimoxazole 4,3%, amoxicillin 2,9%, gentamicin 4,3%, cefotaxime 1.4%) antimicrobial (metronidazole 14,5%) zinc supplements 30,4%,probiotics 2,9%, antipyretics (paracetamol 34,8%) antiemetic (methoclopramide 1,5%) and antidispepsia (omeprazole 2,9%).
EVALUASI POTENSI INTERAKSI OBAT ANTIBIOTIKA PADA PENYAKIT INFEKSI GASTROINTESTINAL PASIEN RAWAT INAP PERIODE JANUARI – JUNI 2016 DI RUMAH SAKIT IBNU SINA MAKASSAR Santi, Irma; Herman, Hendra; Al Ishak, Andi Afifatun Nisa
Jurnal Ilmiah As-Syifaa Vol 12, No 1 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.879 KB)

Abstract

Infective gastrointestinal is gastrointestinal tract inflammation (GIT), which is caused by microorganisms. The symptoms include diarrhea, vomit, abdominal pain, and fever. This study aimed to determine the antibiotic drug interaction potential based on the interaction mechanisms of gastrointestinal infectious diseases of in patients in the period of January to June 2016 at IbnuSina Hospital Makassar and to determine the severity of antibiotic drug interaction using the website www.drugs.com on the gastrointestinal infectious diseases. This research is non experiments conducted by dekskriptif method retrospectively. The results showed that the drug interaction in the therapeutic use along with less potential antibiotics to interact. This was shown that pharmacokinetic interaction mechanism is 3.80% cases and pharmacodynamics interactions is 6.33% cases, while the pharmacokinetic interaction instead of antibiotics is 40.51% cases, and pharmacodynamics interactions is 7.60% cases. Based on the minor or moderate severity levels, the drug interactions between antibiotics and other drugs are 11.39% cases while the drugs which is not the antibiotics of drug interaction case is 32.91% cases.
Co-Authors Al Ishak, Andi Afifatun Nisa Dian Dwi Aninditia, Dian Dwi Marlian, Ayu Rizqi Nur Azizah