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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medika Tadulako Ilmu Gizi Indonesia Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Journal of Community Empowerment for Health
Kusuma, Rio Jati
Departemen Gizi, Fakultas Kedokteran, Universitas Gadjah Mada
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Analisis proksimat kue kering yang disuplementasi cabuk sebagai alternatif Pangan Tinggi Protein-Tinggi Energi Rio Jati Kusuma; Nikita Widya Permata Sari; Tri Yunita; Mubarok Alfa Rizqi
Ilmu Gizi Indonesia Vol 4, No 2 (2021): Februari
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/ilgi.v4i2.192

Abstract

Latar belakang: Malnutrisi akibat kurangnya asupan zat gizi masih menjadi permasalahan kesehatan di Indonesia. Penggunaan bahan makanan berbasis pangan lokal merupakan salah satu alternatif penanganan malnutrisi akibat kekurangan zat gizi makro. Cabuk merupakan makanan fermentasi bungkil wijen dari Wonogiri yang mengandung tinggi protein dan lemak sehingga potensial untuk digunakan pada pembuatan produk bahan makanan campuran yang tinggi protein dan tinggi kalori. Tujuan: Mengevaluasi efek suplementasi cabuk dalam pembuatan kue kering terhadap nilai gizi produk. Metode: Penelitian ini merupakan penelitian eksperimental murni. Cabuk dikeringkan dalam cabinet dryer dengan suhu 50°C, dihomogenisasi dan disaring untuk mendapatkan tepung cabuk. Cabuk kemudian ditambahkan sebanyak 0% sebagai kontrol, 10%, 15% dan 20% ke dalam adonan kue kering. Selanjutnya, dilakukan analisis kadar air, protein, lemak, abu, serat kasar dan energi. Data dianalisis dengan menggunakan Annova Satu Jalur dan uji Duncan. Hasil: Terdapat perbedaan yang signifkan (p<0,001) pada kadar air, abu, protein, lemak, karbohidrat, serat kasar dan energi keempat formula kue kering. Semakin tinggi kadar cabuk yang ditambahkan ke dalam adonan, semakin tinggi kadar abu, protein dan serat kasar produk kue kering. Tidak terdapat perbedaan pada kadar abu, lemak, karbohidrat dan energi produk kue kering yang disuplementasi cabuk 15% dan 20%. Kesimpulan: Suplementasi cabuk potensial digunakan sebagai alternatif pembuatan kue kering tinggi protein tinggi kalori.
Effects of Dioscorea esculenta and Eubacterium rectale on insulin receptor substrate 1 (Irs1) Expression in skeletal muscle and homeostatic model assessment-insulin resistance (HOMA-IR) in diabetic rats . Sunarti; Tri Setyawati; Neni Oktiyani; Rio Jati Kusuma
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 3 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (666.589 KB)

Abstract

Low expression of insulin receptor substrate 1 (Irs1) is associated with insulin resistance and type 2 diabetes mellitus (type 2 DM). This study was performed to evaluate the effects of Dioscorea esculenta and Eubacterium rectale on the Irs1 expression in the skeletal muscle and the homeostatic model assessment-insulin resistance (HOMA-IR) of diabetic rats. Twenty-five male Wistar rats were divided into five groups i.e. non diabetic rats Group 1; diabetic rats as Group 2; diabetic rats + D. esculenta as Group 3; diabetic rats + E.rectale as Group 4 and diabetic rats + both E. rectale and D. esculenta as Group 5. Rats were made diabetic with induction of intraperitoneally injection of nicotinamide and streptozotocin. After four weeks of the interventions, the blood and skeletal muscles were taken. The Irs1 expression was analyzed with immunohistochemical staining, plasma glucose levels was analyzed using a spectrophotometer, and insulin was analyzed using ELISA methods. All intervention groups reduced plasma glucose levels and HOMA-IRs (p<0.001) and increased Irs1 expression. The greatest reduction of  plasma glucose levels and increase of Irs1 expression in the skeletal muscle were found in Group 4, however, the lowest of HOMA-IR was seen in Group 5. These results suggested that D.esculenta, E.rectale, and the combination reduced plasma glucose levels and HOMA-IR by increasing Irs1 expression in skeletal muscle.
Addition of conjugated linoleic acid in whole milk improves lipid profile in high fat diet induced hypercholesterolemia of rats Arta Farmawati; Rio Jati Kusuma; Bayu Sigha Iswara; . Wulandari; Kurniati Dwi Utami; Istiti Kandarina
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 4 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.571 KB) | DOI: 10.19106/JMedSci004804201601

Abstract

Conjugated linoleic acid (CLA) is an isomer of linoleic acid that has been shown to havemany beneficial effects in prevention of atherosclerosis, hypertension, cardiovasculardiseases and improve immune function. Although majority of CLA in the diet are derivedfrom dairy product such as milk, however, the content of CLA in milk is affected by cow’sdiet. The aim of this study was to investigate the beneficial effect of CLA supplementationin milk for improving lipid profile in high fat diet of rats. Twenty four male Sprague Dawleyrats aged 8 weeks were given high fat diet for 3 weeks to induce hypercholesterolemia.Six rats were maintained in standard diet as control. Rats then were divided into 4 groupsi.e. normal control, negative control, high fat diet+CLA 0.5%, high fat diet + CLA 0.5%supplemented skim milk, and high fat diet + CLA 0.5% supplemented whole milk. Bloodsample was drawn after high fat diet induced hypercholesterolemia and after 4 weeksof treatment for total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDLcholesterol), and high density lipoprotein cholesterol (HDL cholesterol) analysis. Bodyweight was measured each week. Results showed that body weight was significantlyincrease in all groups received high fat diet (p<0.05). There was no significant differencein body weight between treatment group (p>0.05). Total cholesterol, triglyceride, andLDL cholesterol was significantly decrease in whole milk followed by significant increasein HDL cholesterol level. Skim milk supplemented with CLA had only modest effect ontriglyceride and HDL cholesterol level. In conclusion, CLA supplementation in whole milkimproves lipid profile in high fat diet.
Dietary fiber and carboydrate contents of gathotan and gathot as functional food for people with diabetes mellitus Puspita Mardika Sari; Desty Ervira Puspaningtyas; Rio Jati Kusuma
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 5, ISSUE 2, 2017
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (16.894 KB) | DOI: 10.21927/ijnd.2017.5(2).88-92

Abstract

Background : Gathotan and gathot are Indonesian cassava traditional fermented food from Gunungkidul, Yogyakarta. These fermented foods may be considered as an important component of a functional-foods based diet for management of type 2 diabetes mellitus (DM). Previous study found that gathotan and gathot hadve low glycemic index (GI). Fermentation processed using fungi and bacteria hadve potency to give many beneficial effects, such as prebiotic that gives contribution on the forming of short chain fatty acid (SCFA). SCFA gives many beneficial effects on metabolism and prognosis on DM type 2. However, there have been no study on the potency of gathotan and gathot as dietary fiber sources.Objectives: This study was designed to examine carbohydrate and dietary fiber content in gathotan and gathot as functional food for people with DM.Methods: Gathotan was made by spontaneous fermentation. Gathot was made by soaking overnight of gathotan, then steaming and drying. Carbohydrates content was calculated by using “carbohydrate by diference” method. Dietary fiber content was analyzed by using enzymatic gravimetri method.Results: The highest carbohydrate content was found in cassava (81,13%), followed by gathotan (68,32%), and gathot (39,03%), respectively. The highest dietary fiber content was found in gathot (17,36%), followed by gathotan (14%), and cassava (8,61%) respectively.Conclusions: Fermentation process of cassava to be gathotan and gathot are potential to increase dietary fiber and decrease carbohydrate content. KEYWORDS: gathotan, gathot, functional food, diabetes mellitus.
The association of six-minutes walking test (6MWT) with cardiovascular disease risk among older women with type 2 diabetes mellitus in a rural primary health care: a pilot observational study Rakhmat Ari Wibowo; Arum Tri Wahyuningsih; Rio Jati Kusuma; Wahyu Pamungkasih; Denny Agustiningsih
Journal of Community Empowerment for Health Vol 3, No 1 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.47599

Abstract

The recent systematic review found that cardiovascular events contributed to approximately half of all deaths among patients with type 2 diabetes mellitus (T2DM). Several studies suggested that the six-minutes walking test (6MWT) could be a valuable prognostic tool for predicting cardiovascular disease (CVD) events in particular diseases. However, less is known concerning the role of 6MWT in predicting CVD events among patients with T2DM. Thus, this pilot observational study aimed to test the feasibility of conducting the 6MWT and to examine the association of measures collected during 6MWT with ASCVD risk estimator parameters for predicting CVD events among T2DM patients. Fourteen older women with T2DM in a rural primary health care were enrolled in this cross-sectional study. Blood pressure measurement, heart rate measurement, and blood sampling for HDL, LDL, and total cholesterol measurements were carried out during rest. Both heart rate and distance were measured at the end of the following 6MWT. Feasibility data were collected. Recruitment rate and measurement completion rate were 85.7% and 40% respectively. No adverse events during the 6MWT were reported. Patient’s heart rate at the end of 6MWT was correlated with diastolic blood pressure (r=0.5 p=0.48). Multivariate analyses suggested that every one-meter increase in distance of 6MWT, there is a decrease in diastolic blood pressure of -0.9 mmHg (p=0.01; 95% CI= -1.6 to -0.2). In conclusion, 6MWT is a feasible simple test which could provide a valuable prediction of ASCVD risk among older women with T2DM. Thus, this test should be considered to be conducted as a part of routine examination. Cohort study with a larger sample could be suggested to establish the usefulness of the 6MWT in predicting CVD risk.
ANTIHIPERGLIKEMI PATI GEMBILI (DIOSCOREA ESCULENTA) DAN EUBACTERIUM RECTALE PADA MODEL TIKUS DIABETES YANG DIINDUKSI STREPTOZOTOCIN DAN NIKOTINAMID Tri Setyawati; Neni Oktiyani; Rio Jati Kusuma; Tony Adi Setiawan; Sunarti Sunarti
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan Vol 2, No 2 (2015)
Publisher : Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang. Diabetes merupakan salah satu penyakit degenaratif dengan prevalesi cukup tinggi di Indonesia. Diabetes tipe 2 memiliki prevalensi paling tinggi diantara jenis diabetes yang lain. Diabetes tipe 2 merupakan kondisi hiperglemia kronis yang umumnya disebabkan oleh resistensi insulin. Diet dengan resistant starch berpotensi untuk meningkatkan sensitivitas insulin pada penderita diabetes melalui butirat yang dihasilkan pada saat fermentasi di usus besar. Salah satu bahan pangan yang berpotensi dalam penanganan diabetes adalah gembili (Dioscorea esculenta). Eubcaterium rectale (e. rectale) merupakan bakteri butirogenik yang dapat meningkatkan produk butirat di dalam kolon.Tujuan. Tujuan penellitian ini adalah untuk mengetahui penurunan glukosa darah pada tikus Wistar yang diinduksi nikotinamide dan streptozotosin setelah pemberian diet gembili dan eubacterium rectale.Metode. Penelitian ini menggunakan desain pre dan posttest kontrol. Tikus jantan Wistar 3 bulan, dibagi menjadi 5 kelompok yaitu kelompok kontrol sehat (K1), kelompok yang diinduksi Streptozotocin (STZ) dan nikotinamide(NA) tanpa terapi (K2), kelompok yang diinduksi STZ dan NA dengan pemberian e. ractale (K3), kelompok induksi ditambah pati gembili (K4), dan kelompok induksi dengan sinbio pati gembili dan e. rectale (K5). Dengan lama intervensi 4 minggu.Hasil. Terjadi penurunan kadar glukosa darah setelah intervensi 4 minggu yaitu antara kelompok K2 dan K3, K4 dan K5 dengan nilai signifikansi p < 0,05.Kata kunci: diabetes tipe 2, Dioscorea esculenta, resistant starch, butirat, resistensi insulin, sensitivitas insulin.
Co-Authors . Wulandari Arta Farmawati Arum Tri Wahyuningsih Bayu Sigha Iswara Desty Ervira Puspaningtyas Istiti Kandarina Kurniati Dwi Utami Mubarok Alfa Rizqi Neni Oktiyani Neni Oktiyani Nikita Widya Permata Sari Puspita Mardika Sari Rakhmat Ari Wibowo Sunarti, Sunarti Tony Adi Setiawan Tri Setyawati Tri Yunita Wahyu Pamungkasih