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All Journal Life Science and Biotechnology
Fahma Wardah Sururin
Biology, FMIPA, Jember University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Journal : Life Science and Biotechnology

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Prediction Prediction of the Insecticidal Potency of Biduri Plants (Calotropis gigantea) using the PASS online web resource Fahma Wardah Sururin; Nida An Khafiyya
Life Science and Biotechnology Vol 2 No 1 (2024): May 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i1.47444

Abstract

Calotropis gigantea, a wild plant thriving in arid environments, has been traditionally used for medicinal purposes by communities near Baluran National Park (BNP). The latex of C. gigantea is used as a crab poison due to its ability to cause fatal damage and separation of body parts, possibly related to chitin disruption in insects. This study explores the potential insecticidal properties of secondary metabolites in C. gigantea using Prediction of Activity Spectra for Substance (PASS) Online. Out of 68 identified secondary metabolites, six show significant insecticidal potential, namely Profenophos, Ethion, Alpha-Citral, 1-Phenylethyl acetate, (E)-dec-3-en-2-one, and Benzaldehyde. Notably, Profenophos, Ethion, Alpha-Citral, and Benzaldehyde exhibit toxic properties effective against insects, with enzyme inhibitory activity affecting nerve signaling and immune systems, suggesting potential for bio-insecticide development.
Co-Authors Nida An Khafiyya