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All Journal ACTA VETERINARIA INDONESIANA Jurnal Veteriner Indonesia Medicus Veterinus Farmaka Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Kesehatan Andalas Folia Medica Indonesiana Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Indonesian Journal of Science and Technology The Indonesian Biomedical Journal IDJP (Indonesian Journal of Pharmaceutics) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Pharmacology and Clinical Pharmacy Research Journal of Tropical Pharmacy and Chemistry Jurnal Informatika Kaputama Jurnal Ilmiah Farmako Bahari Jurnal Ilmu Faal Olahraga Indonesia Jurnal Pengabdian Olahraga Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

Ronny Lesmana

Department Of Anatomy, Physiology And Biology Cell, Faculty Of Medicine, Universitas Padjadjaran, Sumedang 45363, Indonesia

Author-ID : 716099

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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Ethionamide Modulates of Thyroid Stimulating Hormone, Thyroxine, and Triiodothyronine Levels in White Ratstimulating Hormone (TSH), Thyroxine (T4), and Triiodothyronine (T3) Serum are potentially modulated Level by Ethionamide in Rats ronny lesmana; Fani Rahma Yenita; Prayudi Santoso; Hanna Goenawan; Arto Yuwono Soeroto; Yuni Susanti Pratiwi; Nova Sylviana; Iwan Setiawan; Vita Murniati Tarawan; Unang Supratman
Jurnal Veteriner Vol 21 No 3 (2020)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.585 KB)

Multidrug-Resistant Tuberculosis (MDR-TB) infection is not solely caused serious impact for patient and cause long recovery process. Multidrug-Resistant Tuberculosis needs specific treatment approach using second-line TB drugs. Ethionamide as one of medication used in MDR-TB are known to cause greater side effects compared to the first-line drugs. One of side effect like hypothyroidism is remain unclear. There is limited study about role of ethionamide cause hypothyroidism. In this present study, 24 male, wistar rats were divided into three groups: ethionamide group; positive control positive (propylthiouracil) and negative control group (received distilled water only) and treated accordingly for 12 week. Under ketamine and xylazine anesthesia, blood sample were collected from retroorbital vein at 8 and 12 week, put in EDTA tube and stored -20Ë%C until use. After last sampling, rat were sacrificed using CO2 chamber. Our data showed that thyroid stimulating hormone (TSH) levels in ethionamide group is increased from 8 weeks to 12 weeks significantly, but there is no significant changes in control groups. Thyroxine (T4) levels is trend decreased from 8 weeks to 12 weeks compared to control groups. There is no change of Triiodothyronine (T3) levels. Effect of ethionamide on thyroid hormone (T3 and T4) levels was not prominent and there were no significant changes observed. Interestingly, we observed an increase of TSH level after ethionamide treatment. Taken together, 12 week treatment of ethionamide tablet might potentially modulate thyroid hormone (T3 and T4) levels that is reflected from an increase of TSH levels in the plasmas feed back negative mechanism.

Study of Pre and Post Supplementation Green Tea Extracts to MDA Levels Goenawan, Hanna; Lesmana, Ronny; Huda, Fathul; Baniasih, Akbar I.; Farenia, Reni; Purba, Ambrosius
Indonesian Journal of Clinical Pharmacy Vol 2, No 1 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (625.104 KB)

High intensity exercise (HI) induces oxidative stress. Running for 2400 meters is one of the simple exercise form which can be counted as HI. During HI, increase of oxygen consumption happened in muscle cell resulted in an increase of oxidant level. The aim of the study was to measure the effects of Indonesian green tea supplementation, before and after HI to the level of lipid peroxidation (TBARSMalonyldialdehyde (MDA)). The subjects of study were 42 male students from Faculty of Medicine, Universitas Padjadjaran (FMUP) and Faculty of Physical Exercise, Indonesia University of Education (FPOK-UPI). The subjects were divided into trained and untrained subject. Subjects were divided into groups using Astrand Harvard step test. The purpose of this test was measuring the level of VO2 max. Blood samples for MDA level were collected at 3 hours before and after high intensity aerobicÂ exercise. Oxidative stress was induced by 2400 meters run. The result showed that green tea supplement-ation was effective to decrease MDA plasma level especially after exercise. Green tea could serve as natural antioxidant resources, which potentially can be used as potential sport supplemental drink.Key words: Aerobic exercise, Malonyldialdehyde (MDA), pre and post exerciseStudi Pra dan Pasca Pemberian Suplemen Ekstrak Teh Hijauterhadap Kadar MDAHigh intensity exercise (HI) dapat menginduksi stres oksidatif. Berlari sejauh 2400 meter merupakan salah satu bentuk latihan sederhana yang dapat digolongkan sebagai HI. Selama HI, konsumsi oksigen pada sel otot meningkat yang dapat menyebabkan peningkatan kadar oksidan. Penelitian ini bertujuanuntuk mengukur efek dari suplemen teh hijau Indonesia sebelum dan setelah HI terhadap kadar lipid peroksida (TBARS-Malonyldialdehyde (MDA)). Subjek penelitian ini adalah 42 mahasiswa laki-laki dari Fakultas Kedokteran Universitas Padjadjaran dan Fakultas Pendidikan Olahraga dan Kesehatan,Universitas Pendidikan Indonesia. Subjek penelitian dibagi ke dalam kelompok terlatih dan tidak terlatih dengan menggunakan cara pengujian Astrand Harvard. Tes ini bertujuan untuk mengukur kadar VO2 max. Sampel darah untuk kadar MDA diambil 3 jam sebelum dan setelah high intensity aerobic exercise. Stres oksidatif diinduksi dengan berlari sejauh 2400 meter. Hasil penelitian menunjukkan bahwa suplemen teh hijau efektif dalam menurunkan kadar MDA dalam plasma khususnya setelah berlari. Teh hijau dapat menjadi sumber antioksidan alami yang berpotensi sebagai minuman suplemen olahraga.Kata kunci: Aerobic exercise, Malonyldialdehyde (MDA), sebelum dan setelah berlari

ROLE OF RESISTANCE EXERCISE IN CONTROLLING INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND IT’S ASSOCIATION WITH METABOLIC DISEASE PREVENTION Fitri Fadhilah; Abdul Hadi Hassan; Hanna Goenawan; Herry Herman; Aziiz Mardanarian Rosdianto; Ronny Lesmana
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 2, No 1 (2019)
Publisher : PAIFORI

Based on data Riset Kesehatan Dasar (Riskesdas) in 2007, the number of people who had no or low physical activity reached 48.2 %. This condition contributes to the increasing number of metabolic disease cases such as hypertension, heart disease, stroke, and diabetes mellitus. Optimizing training approaches especially the aerobic type helps to counter metabolic diseases. Unfortunately, the benefits of resistance training (RT) are less understood. RT improves muscle strength, induces muscle hypertrophy, improvement of local muscular performance, and also helps to strengthen body balance and coordination. There is an interplay between training and hormone in muscle adaptation during resistance training. The hormone plays an important role in the regeneration of muscle after resistance training. The changes in hormone level cause hypertrophy. Regeneration and muscle hypertrophy are mediated by activation, proliferation, and differentiation of satellite cells. It is regulated by mitotic and myogenic activity, namely insulin-like growth factor-1 (IGF-1), which serves as a paracrine or autocrine. A better understanding of homeostasis hormone during training in skeletal muscle and its ultimate purpose to counter metabolic disease will lead us to a better treatment approach for the patient.

Efek Astaxanthin dan Latihan Teratur terhadap Pola Stres Oksidatif Pria Setelah Aktivitas Berat Gunawan, Hanna; Sylviana, Nova; Purba, Ambrosius; Lesmana, Ronny; Akbar, Ieva B.
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Aktivitas fisik berat meningkatkan senyawa oksigen reaktif dalam tubuh yang diketahui dengan mengukur kadar malondialdehid (MDA) dari hasil proses lipid peroksidase yaitu kerusakan oksidatif pada biomolekul lipid akibat reaktivitas senyawa oksigen reaktif (SOR), namun pola perubahan kadar MDA plasma seseorang setelah beraktivitas fisik berat masih belum dipahami. Antioksidan potensial seperti astaxanthin dan latihan teratur diduga dapat memengaruhi pola perubahan kadar MDA tersebut. Untuk itu dilakukan penelitian eksperimental dengan subjek 15 orang pria terlatih dan 15 orang pria tidak terlatih anggota sebuah pusat kebugaran di Bandung, usia 18â25 tahun yang terbagi menjadi kelompok yang mendapatkan suplemen astaxhantin atau plasebo selama satu minggu secara buta ganda. Setelah pemberian suplemen atau plasebo, setiap kelompok melakukan tes aktivitas anaerobik berat. Dilakukan pengukuran MDA rerata (mmol/mL) sebelum dilakukan tes, langsung setelah tes, 6 jam setelah tes, dan 24 jam setelah tes. Data yang dianalisis menggunakan uji ANOVA diikuti uji Duncan menunjukkan bahwa sebelum tes keempat kelompok mempunyai rerata yang hampir sama, sementara rerata MDA yang diperiksa pada setelah tes pada kelompok pria terlatih dengan suplementasi astaxanthin memiliki rerata MDA terendah, sementara yang tertinggi pada kelompok pria tak terlatih dengan plasebo (p<0,05). Perubahan rerata MDA pada setiap kelompok menunjukkan pola dinamis sama yaitu meningkat tajam langsung setelah tes latihan fisik, mulai mengalami penurunan pada jam keâ6 dan kembali ke rerata awal pada jam keâ24 (p<0,05), kecuali pada kelompok pria tak terlatih dengan plasebo meningkat 2 kali dari nilai awal. Hal ini menunjukkan astaxanthin dan latihan mempunyai efek positif terhadap peningkatan kadar MDA namun tidak memengaruhi pola perubahannya setelah aktivitas fisik berat.

Efek Penggunaan Probiotik Topikal Terhadap Ekspresi MMP-13 dan Kolagen III pada Lapisan Dermis Tikus yang Dipapar Sinar Ultraviolet-B Tarawan, Vita M.; Anissa, Anissa; Sutedja, Endang; Lesmana, Ronny
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Proses penuaan kulit terjadi karena kombinasi penurunan kapasitas proliferasi sel-sel kulit, berkurangnya sintesis matriks dermis, dan peningkatan ekspresi enzim yang mendegradasi matriks kolagen. Penelitian ini merupakan eksperimental laboratorik, menggunakan 24 ekor tikus jantan galur Sprague-Dawley sebagai objek penelitian. Pada kelompok perakuan, kulit dorsal kedua kelompok dicukur, kemudian diberikan paparan sinar UVB seminggu tiga kali selama 4 minggu dengan dosis total penyinaran 840 mJ/ cm2. Kulit kelompok perlakuan diolesi krim Lactobacillus plantarum FNCC 0020 yang tidak bereplikasi, sehari 2 kali dengan komposisi aplikasi topikal koloni 247,27x107, sedangkan kelompok kontrol tidak diolesi apapun. Hasil penelitian diperoleh, baik intensitas, distribusi, maupun histoskor MMP-13 antara kelompok perlakuan dan kelompok kontrol tidak menunjukkan ada perbedaan yang bermakna (p>0,05). Intensitas kolagen III baik pada kelompok perlakuan maupun kontrol semua mempunyai derajat kuat, sedangkan distribusi kepadatan kolagennya paling rendah 20â50% dan tertingginya di atas 80%. Perbandingan distribusi kepadatan kolagen III secara statistik sangat bermakna (p<0,01). Pemberian krim topikal L. plantarum FNCC 0020 meningkatkan ekspresi distribusi kepadatan kolagen III namun tidak menurunkan ekspresi MMP-13.Â Kata kunci: Lactobacillus plantarum, kolagen, (matrix metalloproteinases) MMP13Â Effect of Topical Probiotic on MMP-13 and Collagen III Expression in The Dermis Layer of Male Rats Irradiated with Ultraviolet-B Abstract Nowadays, there is a big interest in the use of topical probiotic preparations for skin health. One of the probiotics therurapeutic benefits is used as anti-aging. During aging, there is stimulation of activator protein-1 (AP-1) which is a transcription factor that inhibits the production of collagen and AP-1 supports the breakdown of collagen by enzymes called matrix metalloproteinases (MMPs). As administration of oral Lactobacillus plantarum could inhibit skin aging by lowering the activity of MMP, so the collagen degradation can be derived so probably topical use of Lactobacillus plantarum may give more prominent effects. We used 24 male rats Sprague-Dawley strain as research objects. This study was divided into two groups, the treatment and control groups. The shaved dorsal skin of rats were irradiated with UVB three times a week for 4 weeks with total irradiation dose of 840 mJ/cm2. Skin cream, containing 247.27x107 CFU non-replicating Lactobacillus plantarum FNCC 0020, was smeared on the treatment group, two times daily, whereas the control group did not receive any treatment. Skin biopsies were done at the end of the study for examination of MMP-13 and collagen III expressions. Intensity, distribution, and histoscore of MMP-13 between the treatment and the control group showed no significant difference (p>0.05). The treatment group showed a significant different in the intensity of collagen III with the density distribution of 20â50% and the highest density was 80% (p<0.01). Administration of topical cream L. plantarum FNCC 0020 increased the expression of collagen III density distribution, but not the MMP-13 expression.Keywords: Collagen, Lactobacillus plantarum, (matrix metalloproteinases) MMP13

EFFECT OF ACUTE AEROBIC PHYSICAL ACTIVITY ON SKELETAL MUSCLE MYOD GENE EXPRESSION OF WISTAR RATS Pratiwi, Yuni Susanti; Aldo, Mochammad; Lesmana, Ronny; Goenawan, Hanna; Goenadi, Julia Windi; Setiawan, Setiawan
Majalah Kedokteran Bandung Vol 51, No 1 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Aerobic physical activity is known to induce skeletal muscle adaptation. Some genes, including MyoD, are known to have a major role in the process of muscle adaptation. Several studies has stated that the expression of MyoD increases during the aerobic activity process; however, the studies were carried out in a single bout. Studies on the effects of acute phase exercise (<2 weeks) are still rare, especially those regarding the difference effect of acute training phase at different times. This study was performed in 2018 at the Central Laboratory and Animal Physiology Laboratory, Faculty of Medicine, Universitas Padjadjaran. The aim of this study was to determine the different effects of MyoD gene expression in a two-week acute aerobic physical activity. The effects were measured in the skeletal muscle in day 3, 7, and 14 of the activity. Twenty four male rats (rattus novergicus) were divided into 4 groups. Those rats in the treatment groups were run on an animal treadmill (P1=3 days, P2=7 days, and P3=14 days). On the last day of ran, rats were sacrificed and the soleus and gastrocnemius muscles were dissected. The expression of the MyoD gene in both muscles was then amplified using reversed PCR and detected by agarose gel electrophoresis. This study showed that there were differencesin MyoD gene expression levels in both muscles and that the level increased with days of treatment, although it was statistically insignificant. This study concludes that the MyoD gene expression level is not significantly affected by an acute aerobic physical activity in certain periods (3, 7 and 14 days).Key words: Acute, Aerobic physical activity, gastrocnemius, MyoD, rats, soleus Perbedaan Pengaruh Aktivitas Aerobik Akut Intensitas Sedang terhadap Ekspresi Gen MyoD pada Otot Rangka Tikus Galur WistarAktivitas fisik aerobik diketahui menginduksi adaptasi otot rangka. Beberapa gen diketahui memiliki peran utama dalam proses adaptasi otot termasuk MyoD. Dalam beberapa penelitian diketahui bahwa ekspresi MyoD meningkat selama proses aktivitas aerobik, tetapi penelitian dilakukan dalam pertarungan tunggal. Penelitian tentang efek latihan fase akut (<2 minggu) masih belum banyak dilakukan, terutama mengenai perbedaan efek fase latihan akut pada periode tertentu (3, 7, dan 14 hari). Penelitian ini dilakukan pada tahun 2018 di Laboratorium Sentral dan Laboratorium Fisiologi Hewan Fakultas Kedokteran Universitas Padjadjaran. Tujuan penelitian ini adalah mengetahui perbedaan efek ekspresi gen MyoD dalam aktivitas fisik aerobik akut pada berbagai hari (3, 7, 14 hari) pada otot rangka. 24 tikus jantan Rattus novergicus dibagi menjadi 4 kelompok. Kelompok perlakuan dijalankan dengan treadmill hewan (P1=3 hari, P2=7 hari, dan P3=14 hari). Pada hari terakhir, tikus dikorbankan dengan soleus dan otot gastroknemius dibedah. Ekspresi gen MyoD pada kedua otot kemudian diamplifikasi menggunakan PCR terbalik dan dideteksi dengan elektroforesis gel agarosa. Penelitian ini menunjukkan perbedaan level ekspresi gen MyoD pada kedua otot, hasil ini menunjukkan bahwa ada peningkatan level perawatan per hari, walaupun secara statistik tidak signifikan. Penelitian ini menyimpulkan bahwa pada otot gastrocnemius tidak terlihat efek yang berbeda dari durasi aktivitas fisik aerobik terhadap tingkat ekspresi gen MyoD, hanya otot soleus menunjukkan perubahan dan peningkatan ekspresi konsisten terlihat pada hari ke 14 (3, 7, dan 14 hari).Kata kunci: Aktivitas fisik aerobik, akut, gastroknemius, MyoD, soleus, tikus

Tinjauan Pustaka : Autophagy dan Sarkopenia Pratiwi, Yuni Susanti; Lesmana, Ronny; Setiawan, Setiawan; Purba, Ambrosius
Syifa'Medika Vol 10, No 1 (2019): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v10i1.1781

ABSTRAK Sarkopenia adalah penurunan massa dan fungsi otot rangka yang disebabkan oleh penuaan. Sarkopenia dapat meningkatkan morbiditas dan mortalitas pada lansia. Penyebab dan patofisiologi sarkopenia bersifat kompleks dan belum diketahui secara pasti hingga saat ini. Autophagy diketahui mempunyai peran penting untuk proses eliminasi dan daur ulang protein dan organel yang rusak sehingga sementara pada penuaan proses akumulasi berlebihan organel dan protein yang rusak sebagai konsekuensi metabolisme merupakan salah satu penyebab terjadinya penyakit karena penuaan. Kondisi autophagy basal yang baik mempunyai efek protektif terhadap pemeliharaan massa otot dan stimulasi sel satelit untuk proses regenerasi otot. Sementara di sisi lain, inhibisi autophagy menyebabkan penurunan massa otot dan berhubungan dengan atrofi serat otot pada proses penuaan. Inhibisi autophagy diperlukan di awal fase regenerasi myogenesis otot sarkopenia, namun kemudian diduga melalui peran FoXO,autophagy diaktivasi untuk mengeliminasi sel yang rusak dan biogenesis mitokondria. Keseimbangan dinamis dari autophagy merupakan salah satu faktor kunci peranautophagy yang berperan positif pada pencegahan sarkopenia dan bahkan prosesmyogenesis sebagai tatalaksana sarkopenia.

Effect of Aerobic Exercise on Selenium Level in Plasma Kanakarajah, Sarmmila; Soetedjo, Nanny N. N. M.; Lesmana, Ronny
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Moderate and high aerobic exercises are the activities that can induce high oxidant. Demandof endogen and exogen antioxidant for neutralizing oxidant induced by exercise will playimportant role in maintaining body performance. Microtrace elements, such as selenium,may able to balance high oxidant formation. However, limited research and data have beencollected with regards to the exercise and selenium. Therefore, this research was conductedto investigate the effect of aerobic exercise on selenium level in plasma. An analytic studywith experimental method of data collection was performed from October -November 2016.17 male students with the age between 19-25 years old and without medically compromiseddisease from Universitas Padjadjaran, Jatinangor, were selected as subjects. Blood sampleswere taken pre- and post-aerobic exercise, i.e., brisk walking with the intensity of 4.5 mi/h.Selenium level in plasma was then examined by enzyme linked immunosorbent assay (ELISA)kit as selenium binding protein (SELENBP1). This study found that 11 (65%) subjectshad a decrease in their selenium plasma after exercise (3.1 Â± 2.58 ng/ml), 5 (29%) subjectshad an increase in their selenium plasma after exercise (2.08 Â± 2.8 ng/ml) and 1 (6%) subjecthad unchanged selenium (SELENBP1) plasma (1.4 Â± 1.4 ng/ml) level. Effect of aerobicexercise on selenium level in plasma varied among individuals.Keywords: aerobic exercise, selenium, young adult

Assessment of Plasma Selenium Level based on Dietary Intake among Geriatric Patients Silviana, Ika M.; Yasmin, Nuraini; Lesmana, Ronny
Pharmacology and Clinical Pharmacy Research Vol 1, No 1
Publisher : Universitas Padjadjaran, Indonesia

Low plasma selenium level was associated with the increasing risk of death in geriatric patients, particularly those with multiple comorbidities. The sufficient level of selenium intake as an antioxidant is necessary for this population. This study aimed to investigate the plasma selenium level based on dietary intake in geriatric clinic population at Dr. Hasan Sadikin General Hospital Bandung.This study was a descriptive study using cross-sectional method. Fourteen geriatric patients were selected by consecutive sampling technique. Semiquantitative food frequency questionnaire (SQ-FFQ) was used as a tool to assess dietary intake. Plasma selenium level was measured as selenium binding protein 1 (SELENBP1) using enzyme-linked immunosorbent assay kit. Overall, mean of plasma selenium level of the subjects was 2,68 Âµg/L and mean of selenium intake was 62,85 Âµg/day. Selenium level of the subjects with sufficient selenium intake (85,7%) was 2,62 Âµg/L and selenium level of the subjects with deficient selenium intake (14,3%) was 3,05 Âµg/L. In conclusion, plasma selenium level among geriatric patients was varied and not dependent on dietary intake.Keywords: antioxidant, dietary intake, geriatric, plasma selenium level

Assessment of Plasma Selenium-Binding Protein-1 Level in Geriatric Population Dewi, Annisa F.; Dwipa, Lazuardhi; Lesmana, Ronny
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Geriatric physiologically undergoes aging process that can cause decreasing cell functionand increasing risk of degenerative diseases caused by the accumulation of reactive oxygenspecies (ROS) in the body. Selenium (Se) is an antioxidant, which is needed for maintainingthe balance of ROS. The aim of this study was to observe the selenium-binding protein(SELENBP1) level in relation with the geriatric patients charcateristics including sex, age,body mass index (BMI), activity of daily living (ADL), instrumental activity of daily living(IADL), cognitive function, nutrition, depression, and insomnia status. The study usedcross-sectional quantitative descriptive study design on 14 geriatric patients in Geriatric OutpatientsClinics, at a hospital in Bandung. The data was obtained by interviewing the patientsand then blood samples were taken. The analysis of SELENBP1 was done using ELISA kit.The average level (SD) of SELENBP1 from all of the characteristics group was 2.68 (0.69)ng/ml. The highest SELENBP1 level was identified in female geriatric patients and followedby male and pre-obese groups. The lowest SELENBP1 level was identified in geriatric patientsaged 70-79 years.Keywords: elderly, SELENBP1, selenium.

Co-Authors . SETIAWAN . Susianti . Susianti Abd. Rasyid Syamsuri Abdul Hadi Hassan Achadiyani Agus Muji Santoso Agus Rusdin Agus Syahrani Ahmad Kurniawan Ahmad Kurniawan Ahmad Ramdan Ajeng Diantini Akbar I. Baniasih Aldo Hartono Aldo, Mochammad Alia Bihrajihant Raya Ambrosius Purba Ambrosius Purba Ambrosius Purba Anas Subarnas Anas Subarnas Andrew Citrawan Anggraeni Dyah Sulistiowati Anissa Anissa Anissa, Anissa Annisa F. Dewi Arief Cahyanto Arifin Dwi Saputro Arto Yuwono Soeroto, Arto Yuwono Astrid Feinisa Khairani Astrid, Stephanie Aziis Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Azis Mardanarian Baniasih, Akbar I. Bela Ita Karina Dani Sujana Darmayanti, Meita Dewi, Annisa F. Diah, Anang Wahid M. Dimpuulina Erna Mariati Dwi Putri Larasati Edi Sukmana Edi Sukmana Edward J Hadi Endang Sutedja Endang Sutedja Euis Julaeha Evi Rinata Fajar Ari Widyatmoko Fani Rahma Yenita Fathul Huda Fathurachman Fathurachman Fatona Suraya, Fatona Febriana Kurniasari Ferdyan Efza Filza Yulina Ade Finda Meyditia Fitri Fadhilah Galuga Sinalusur Sari Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Goenadi, Julia Windi Gunadi, Julia Windi Gunawan, Hanna Hadi Hadi Hana Goenawan Hanna Goeanawan Hanna Goenawan Hanna Goenawan Hanna Gunawan Hendra Gunawan Hendy Setiawan Herry Herman Hilmi Al Wahid Huda, Fathul I Made Joni Ieva B. Akbar Ieva Baniasih Akbar Ika M. Silviana Imam Megantara Irma Erika Herawati Irma Erika Herawati Irma Melyani Puspitasari Isa Mahendra Ivan Christian Channel Ivanna Valentina Iwan Setiawan Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Jihan Mudrika Rahmi Julia Windi Gunadi Julia Windi Gunadi Julia Windi Gunadi Jutti Levita Kanakarajah, Sarmmila Keiichi Motoyama Khairani, Astrid Feinisa Lazuardhi Dwipa Lien Herlina Madhani Pradiptha Nugroho Mariel Daba Mas Rizky A.A. Syamsunarno MEGANTARA, SANDRA Muchtaridi Muchtaridi Mulyanaga, William Giovanni Mutakin Mutakin Mutiarahmi, Citra Nur Nabilah Muhamad Nanang Wahyudin Nanny N. N. M. Soetedjo Nasrul Wathoni Norisca Aliza Putri Nova Sylviana Nova Sylviana Nuraini Yasmin Nurul Fadhilah Oki Suwarsa Okta Wismandanu Pardede, Akim Manaor Hara Prasetyo, Wibowo Budi Prayudi Santoso Purwo Sri Rejeki Ramdani Hamzah Ray, Hamidie Ronald Daniel Renaldi Prasetia Reni Farenia Reni Farenia Reni Farenia rima siburian Risna Agustina Roro Wahyudianingsih Rosdianto, Aziiz Mardanarian Santi Sofiyanti Sarmmila Kanakarajah Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Silviana, Ika M. Siti Baitul Mukarromah Siti Baitul Mukarromah Siti Nuriyatus Zahrah Slamet Imron Sri Adi Sumiwi Steffi Liem Sudigdo Adi sugianli, Adhi Sunarjati Soedigdoadi Sunarjati Sudigdo Adi Sunarjati Sudigdo Adi Sunarjati Sudigdoadi Sunaryati S. Adi Supriatno Salam Susanti Husen Susianti Susianti Susianti Susianti Tarawan, Vita M. Tarawan, Vita M. Teresa Lucretia, Teresa Teti Madiadipoera TIANA MILANDA Tina Rostinawati Titing Nurhayati Titing Nurhayati Trianing Tyas Kusuma Tyagita Hartady Unang Supratman Vita M. Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Lubis Vita Mutia Tarawan Willy Bachtiar Yanuar Dwi Prastyo Yasmin, Nuraini Yulia Sofiatin Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Zakiyah, Neily

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