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All Journal ACTA VETERINARIA INDONESIANA Jurnal Veteriner Indonesia Medicus Veterinus Farmaka Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Kesehatan Andalas Folia Medica Indonesiana Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia WMJ (Warmadewa Medical Journal) Indonesian Journal of Science and Technology The Indonesian Biomedical Journal IDJP (Indonesian Journal of Pharmaceutics) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Pharmacology and Clinical Pharmacy Research Journal of Tropical Pharmacy and Chemistry Jurnal Informatika Kaputama (JIK) Jurnal Ilmiah Farmako Bahari Jurnal Ilmu Faal Olahraga Indonesia Jurnal Pengabdian Olahraga Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Ronny Lesmana
Department Of Anatomy, Physiology And Biology Cell, Faculty Of Medicine, Universitas Padjadjaran, Sumedang 45363, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats Setiawan Setiawan; Yuni Susanti Pratiwi; Ronny Lesmana; Galuga Sinalusur Sari; Ahmad Ramdan; Aldo Hartono; Fathurachman Fathurachman; Unang Supratman
Majalah Kedokteran Bandung Vol 54, No 4 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n4.2930

Abstract

Nutmeg as one of Indonesia native plants has already been used widely in herbal treatment. It has been demonstrated that nutmeg presents activities related to mitochondria functions. Nutmeg potentially has the effect of peroxisome proliferator activated receptors Υ (PPAR Υ) which contributes to myogenesis, and may alters mitochondrial homeostasis in respiration and biogenesis. In this study, how nutmeg extract alters oxidative process in skeletal muscle of aging rats was explored. Twenty aging Wistar male rats aged 80 weeks old were divided into two groups (control and nutmeg treatment). Nutmeg extract was administered for 12 weeks using a gavage. After that, the soleus muscles were collected, weighted, frozen, and stored at -800C until used. Nutmeg was observed to increase the COX1 (1.9 folds, p<0.01), COX2 (1.6 folds, p<0.05), and COXIV (2.8 folds, p<0.01) gene expressions, in parallel with increased protein carbonyl levels (1.5 folds, p<0,01). Nutmeg treatment also significantly increased the expressions of antioxidant endogen COQ7 (2 folds, p<0,01) and PDSS2 (2 folds, p<0,01) in the soleus muscle. Taken together, nutmeg extract may improve mitochondrial respiratory oxidative activities in type I aging skeletal muscle.
PENDAMPINGAN AKSELERASI IMPLEMENTASI MBKM KOMUNITAS DKM DI UNIVERSITAS PENDIDIKAN MUHAMMADIYAH SORONG Yanuar Dwi Prastyo; Lien Herlina; Agus Muji Santoso; Alia Bihrajihant Raya; Nanang Wahyudin; Anggraeni Dyah Sulistiowati; Evi Rinata; Anang Wahid Muhammad Diah; Agus Syahrani; Rima Herlina Setiawati Siburian; Willy Bachtiar; Hendy Setiawan; Finda Meyditia; Ronny Lesmana; Arifin Dwi Saputro; Akim Manaor Hara Pardede
Jurnal Informatika Kaputama (JIK) Vol 6, No 2 (2022): Volume 6, Nomor 2 Juli 2022
Publisher : STMIK KAPUTAMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jik.v6i2.1313

Abstract

Komunitas Duta Kampus Merdeka (DKM) 2022 memiliki sifat (nature) go-to-person dalam melaksanakan tugasnya untuk mengakselerasi implementasi kebijakan Merdeka Belajar Kampus Merdeka (MBKM) sesuai dengan spirit transformasi pendidikan tinggi. Oleh karena itu, DKM diharapkan mampu berperan sebagai problem shooter yaitu mampu menjawab dan membantu memecahkan masalah tentang implementasi program Kampus Merdeka baik di lingkungan Perguruan Tinggi (PT) maupun di PT sekitar. Salah satu upaya untuk mengoptimalkan peran dan nature DKM serta membantu penyelesaian masalah dan mengakselerasi implementasi Kampus Merdeka di perguruan tinggi, maka DKM Leads menjalin kerjasama dengan Lembaga Layanan Pendidikan Tinggi (LLDIKTI) untuk melaksanakan kegiatan kolaborasi. Kolaborasi dilaksanakan dalam bentuk Pendampingan Akselerasi Implementasi MBKM yang bertujuan meningkatkan kapasitas DKM sebagai problem shooter dengan solusi yang disampaikan secara on the spot. Selain itu, kegiatan tersebut juga bertujuan untuk meningkatkan sinergi dalam memetakan dan memberikan rekomendasi tematik bagi perguruan tinggi dan program studi yang masih memiliki kendala dalam implementasi Kampus Merdeka. Melalui Pendampingan Akselerasi Implementasi MBKM, DKM dan LLDIKTI dapat membantu mengakselerasi implementasi MBKM secara sistemik dan komprehensif.
Potential Molecular Interaction of Nutmeg’s (Myristica fragrans) Active Compound via Activation of Caspase-3 Ronny Lesmana; Filza Yulina Ade; Yuni Susanti Pratiwi; Hanna Goeanawan; Nova Sylviana; Sandra Megantara; Susianti Susianti; Vita Murniati Tarawan; Purwo Sri Rejeki; Hamidie Ronald Daniel Ray; Unang Supratman
Indonesian Journal of Science and Technology Vol 7, No 1 (2022): IJOST: VOLUME 7, ISSUE 1, April 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i1.45663

Abstract

Myristica fragrans Houtt (belongs to the Myristicaceae family) is a Maluku Island (Indonesia) native plant. The seed of M. fragrans (Nutmeg) has been used for medicinal benefits. M. fragrans also has anti-cancer properties. The goal of this research was to use computer-aided drug design to investigate the in silico molecular docking of selected nutmeg compounds against Caspase-3. Molecular docking using Malegro Virtual Docker (MVD) software Ver 5.5 was performed to investigate binding complicated models to offer information on critical drug-receptor interactions. The most potent ligand was Licarin B, which had a docking score of -103.07 kcal/mol. The Licarin B structure formed several hydrogen bonds with Trp214 and Phe250. These findings imply that the nutmeg seed contains a prospective compound that could be a great anti-cancer agent.
The role of selenium on autophagy Febriana Kurniasari; Hanna Goenawan; Astrid Feinisa Khairani; Sunarjati Sudigdo Adi; Ronny Lesmana; Setiawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art10

Abstract

Selenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth retardation. Its antioxidant properties are integrated into various selenoenzymes, mainly glutathione peroxidase (GPx) and thioredoxin reductase (Trx). These selenoenzymes act as a protective mechanism to prevent oxidative stress-induced cellular injury, regulate DNA transcription, and cell proliferation. Decreased levels of antioxidants induce reactive oxygen species (ROS) accumulation resulting in loss of mitochondrial structure and function. The antioxidant properties of selenium could depress ROS and modulates autophagy by interfering initiation of autophagy and phagophore formation. Inhibition at the initiation stage not only involves mTOR and AMPK, an autophagy-related regulators, but also autophagy markers, including Beclin 1, Atg5, LC3, and p62; thus, phagophore and autophagosome are not formed. This review will discuss the role of selenium in modulating autophagy in various organs.
Changes in the Histological Appearance of White Fat in Young Rats as a Result of Different Exercise Intensities Ronny Lesmana; Diandra Syifa; Yuni Pratiwi; Aziiz Rosdianto; Siti Mukarromah; Hanna Goenawan; Putri Tessa
WMJ (Warmadewa Medical Journal) Vol 8 No 1 (2023): May 2023
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.8.1.5819.27-33

Abstract

Sedentary lifestyle can cause the accumulation of energy reserves in the form of lipids in white adipose cells. Lifestyle modification by means of exercise is done to reduce fat reserves in white adipose tissue (WAT). This study aims to determine the effect of exercise in various intensities on the histological changes of white adipose cells. Research method exploratory with Federer formula to determine the number of samples carried out. Using 28 Wistar rats located at the Central Laboratory of Padjadjran University, Sumedang from May to June 2022. The data taken were the average diameter ± standard error (SEM) of the inguinal white adipose cells of the experimental rats. Data analysis using Microsoft Excel 2016 and SPSS v.28 software. Of the 28 samples studied, only 25 samples met the inclusion criteria. Group K is 0.15% (p = 0.024) greater than P2, and 0.25% (p 0.001) is greater than P3. The P1 group had a value of 0.17% (p = 0.025) greater than P3. Moderate and vigorous exercise can be used to reduce the size of white adipose cells. While low-intensity exercise is considered ineffective. Further research can be carried out to assess changes in white adipose cells based on exercise intensity from other sides besides their morphology. Keywords: Histological, White Adipose Tissue, Exercise
PENDAMPINGAN AKSELERASI IMPLEMENTASI MBKM KOMUNITAS DKM DI UNIVERSITAS PENDIDIKAN MUHAMMADIYAH SORONG Yanuar Dwi Prastyo; Lien Herlina; Agus Muji Santoso; Alia Bihrajihant Raya; Nanang Wahyudin; Anggraeni Dyah Sulistiowati; Evi Rinata; Anang Wahid Muhammad Diah; Agus Syahrani; Rima Herlina Setiawati Siburian; Willy Bachtiar; Hendy Setiawan; Finda Meyditia; Ronny Lesmana; Arifin Dwi Saputro; Akim Manaor Hara Pardede
Jurnal Informatika Kaputama (JIK) Vol 6 No 2 (2022): Volume 6, Nomor 2, Juli 2022
Publisher : STMIK KAPUTAMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59697/jik.v6i2.122

Abstract

Komunitas Duta Kampus Merdeka (DKM) 2022 memiliki sifat (nature) go-to-person dalam melaksanakan tugasnya untuk mengakselerasi implementasi kebijakan Merdeka Belajar Kampus Merdeka (MBKM) sesuai dengan spirit transformasi pendidikan tinggi. Oleh karena itu, DKM diharapkan mampu berperan sebagai problem shooter yaitu mampu menjawab dan membantu memecahkan masalah tentang implementasi program Kampus Merdeka baik di lingkungan Perguruan Tinggi (PT) maupun di PT sekitar. Salah satu upaya untuk mengoptimalkan peran dan nature DKM serta membantu penyelesaian masalah dan mengakselerasi implementasi Kampus Merdeka di perguruan tinggi, maka DKM Leads menjalin kerjasama dengan Lembaga Layanan Pendidikan Tinggi (LLDIKTI) untuk melaksanakan kegiatan kolaborasi. Kolaborasi dilaksanakan dalam bentuk Pendampingan Akselerasi Implementasi MBKM yang bertujuan meningkatkan kapasitas DKM sebagai problem shooter dengan solusi yang disampaikan secara on the spot. Selain itu, kegiatan tersebut juga bertujuan untuk meningkatkan sinergi dalam memetakan dan memberikan rekomendasi tematik bagi perguruan tinggi dan program studi yang masih memiliki kendala dalam implementasi Kampus Merdeka. Melalui Pendampingan Akselerasi Implementasi MBKM, DKM dan LLDIKTI dapat membantu mengakselerasi implementasi MBKM secara sistemik dan komprehensif.
Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding Penny Setyawati Martioso; Diana Krisanti Jasaputra; Julia Windi Gunadi; Ronny Lesmana; Pinkan Al Shabrina
Majalah Kedokteran Bandung Vol 55, No 2 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

High-fat diet habits lead to an increase in LDL-C levels that eventually influence the atherosclerotic plaque formation and progression, causing coronary heart disease. Atherosclerosis is a chronic inflammatory process that releases various pro-inflammatory cytokines, including IL-6. Indonesians often use medicinal plants to decrease cholesterol levels. This study aimed to compare the LDL-C and IL-6 levels after treatments of ethanol extracts from Java ginger (EEJG), turmeric (EET), garlic (EEG), and pomegranate flowers (EEPF) in a hypercholesterolemia animal model. This study was conducted at the Maranatha Biomedical Research Laboratory from June–December 2020. Male Wistar rats were divided into six groups (n=5 per group) and received high-fat feeding and 0.01% propylthiouracil. The following treatments were given for 28 days: oral carboxymethylcellulose 1% for negative control; 35 mg/200g of oral  EEJG, EET, EEG, EEPF for respective treatment groups (n=5 groups); and 0.36 mg/200 g of oral Rosuvastatin for positive control. It was demonstrated that the mean  LDL-C levels were 65.75 mg/dL, 55.25 mg/dL, 56.75 mg/dL, and 59.60 mg/dL for EEJG, EET, EEG, EEPF groups, respectively, which were significantly different from that of the negative control (81.73 mg/dL). The IL-6 levels of the EEJG (27.55 pg./mL) and EEG (27.54 pg./mL) group were significantly different from the EEPF group (24.5 pg./mL) but not significantly different from the negative control (25.58 pg./mL), EET (25.60 pg./mL), and rosuvastatin (26.09 pg./mL) groups. The administration of ethanol extracts of Java ginger, turmeric, garlic, and pomegranate flower decreases the C-LDL levels; however, only the ethanol extract of pomegranate flowers administered for 28 days decreases the IL-6 levels of Wistar rat hypercholesterolemia model, albeit insignificantly.
Pengaruh Ekstrak Kunyit dan Kulit Manggis Terhadap Ekspresi Gen PPARα Pada Retina Model Tikus yang Dinduksi DTL Yenny Noor; Diana K Jasaputra; Julia W Gunadi; Ronny Lesmana; Riska A Safira
Journal of Medicine and Health Vol 5 No 2 (2023)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v5i2.6684

Abstract

A long-term high-fat diet (HFD) was proven to induce metabolic dysfunction and causes various organ inflammation, including the retina. As the regulator of lipid metabolism, PPARa plays a role in retinal lipid metabolism and served as one of the targets for decreasing lipid deposition in the retina. Turmeric and mangosteen peel are Indonesian medicinal herbs with enormous health effects, including antiinflammation and hypolipidemic properties. This study aims to determine the effect of ethanol extract from turmeric and mangosteen peel on PPARa  gene expression in the retina of an HFD-induced rat model. Twenty male Wistar rats were divided into 5 groups: negative control, positive control, turmeric, mangosteen, and fibrate. At the end of the study, total cholesterol and triglyceride levels from the blood were measured. The retina was extracted to conduct Realtime PCR for PPARα gene expression. The result showed a significant difference in triglyceride levels between positive control and turmeric groups, and PPARa gene expression in the retina between the control negative, positive, and turmeric groups, but no significant difference was found in other groups. This study concludes that the extract of turmeric increases the expression of the PPARa gene expression in the retina in an HFD-induced rat model.
Co-Authors . SETIAWAN . Susianti Abd. Rasyid Syamsuri Abdul Hadi Hassan Achadiyani Agus Muji Santoso Agus Rusdin Agus Syahrani Agus Syahrani Ahmad Kurniawan Ahmad Kurniawan Ahmad Ramdan Ajeng Diantini Akbar I. Baniasih Aldo Hartono Aldo, Mochammad Alia Bihrajihant Raya Alia Bihrajihant Raya Ambrosius Purba Ambrosius Purba Ambrosius Purba Anang Wahid Muhammad Diah Anas Subarnas Anas Subarnas Andrew Citrawan Anggraeni Dyah Sulistiowati Anggraeni Dyah Sulistiowati Anissa Anissa Anissa, Anissa Annisa F. Dewi Arief Cahyanto Arifin Dwi Saputro Arto Yuwono Soeroto, Arto Yuwono Astrid Feinisa Khairani Astrid, Stephanie Aziis Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Aziiz Rosdianto Azis Mardanarian Baniasih, Akbar I. Bela Ita Karina Dani Sujana Darmayanti, Meita Dewi, Annisa F. Diah, Anang Wahid M. Diana K Jasaputra Diana Krisanti Jasaputra Diandra Syifa Dimpuulina Erna Mariati Dwi Putri Larasati Edi Sukmana Edi Sukmana Edward J Hadi Endang Sutedja Endang Sutedja Euis Julaeha Evi Rinata Evi Rinata Fajar Ari Widyatmoko Fani Rahma Yenita Fathul Huda Fathurachman Fathurachman Fatona Suraya, Fatona Febriana Kurniasari Ferdyan Efza Filza Yulina Ade Finda Meyditia Finda Meyditia Fitri Fadhilah Galuga Sinalusur Sari Genta Syaifrin Laudza Gilang Muhamad Nur Iqbal Goenadi, Julia Windi Gunadi, Julia Windi Gunawan, Hanna Hadi Hadi Hana Goenawan Hanna Goeanawan Hanna Goenawan Hanna Goenawan Hanna Goenawan Hanna Gunawan Hendra Gunawan Hendy Setiawan Hendy Setiawan Herlina, Lien Herry Herman Hilmi Al Wahid Huda, Fathul I Made Joni Ieva B. Akbar Ieva Baniasih Akbar Ika M. Silviana Imam Megantara Irma Erika Herawati Irma Erika Herawati Irma Melyani Puspitasari Isa Mahendra Ivan Christian Channel Ivanna Valentina Iwan Setiawan Iwan Setiawan Iwan Setiawan Iwan Setiawan Jatnika, Danti Dja Jihan Mudrika Rahmi Julia W Gunadi Julia Windi Gunadi Julia Windi Gunadi Julia Windi Gunadi Julia Windi Gunadi Jutti Levita Kanakarajah, Sarmmila Keiichi Motoyama Khairani, Astrid Feinisa Lazuardhi Dwipa Madhani Pradiptha Nugroho Mariel Daba Mas Rizky A.A. Syamsunarno MEGANTARA, SANDRA Muchtaridi Muchtaridi Mulyanaga, William Giovanni Mutakin Mutakin Mutiarahmi, Citra Nur Nabilah Muhamad Nanang Wahyudin Nanang Wahyudin Nanny N. N. M. Soetedjo Nasrul Wathoni Norisca Aliza Putri Nova Sylviana Nova Sylviana Nuraini Yasmin Nurul Fadhilah Oki Suwarsa Okta Wismandanu Pardede, Akim Manaor Hara Penny Setyawati Martioso Pinkan Al Shabrina Prasetyo, Wibowo Budi Prayudi Santoso Purwo Sri Rejeki Putri Tessa Ramdani Hamzah Ray, Hamidie Ronald Daniel Renaldi Prasetia Reni Farenia Reni Farenia Reni Farenia rima siburian Riska A Safira Risna Agustina Roro Wahyudianingsih Rosdianto, Aziiz Mardanarian Santi Sofiyanti Sarmmila Kanakarajah Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Silviana, Ika M. Siti Baitul Mukarromah Siti Mukarromah Siti Nuriyatus Zahrah Slamet Imron Sri Adi Sumiwi Steffi Liem Sudigdo Adi sugianli, Adhi Sunarjati Soedigdoadi Sunarjati Sudigdo Adi Sunarjati Sudigdo Adi Sunarjati Sudigdoadi Sunaryati S. Adi Supriatno Salam Susanti Husen Susianti Susianti Susianti Susianti Tarawan, Vita M. Tarawan, Vita M. Teresa Lucretia, Teresa Teti Madiadipoera TIANA MILANDA Tina Rostinawati Titing Nurhayati Titing Nurhayati Trianing Tyas Kusuma Tyagita Hartady Unang Supratman Vita M. Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Lubis Vita Mutia Tarawan Willy Bachtiar Willy Bachtiar Yanuar Dwi Prastyo Yasmin, Nuraini Yenny Noor Yofita Sandra, S.Pd., M.Pd., Zico Farlin, Dr. Budiwirman, M.Pd., Yulia Sofiatin Yuni Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Zakiyah, Neily