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All Journal Althea Medical Journal Indonesian Journal of Obstetrics & Gynecology Science Andalas obstetrics and gynecology journal Indonesian Journal of Cancer
Kemala Isnainiasih Mantilidewi
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Padjajaran-Dr. Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Determinants of Insecticide-treated Net use among Pregnant Women with Malaria in West Papua, Indonesia Tita Husnita Madjid; KI Mantilidewi; H Susiarno; Ari Irawan Romulya
Andalas Obstetrics And Gynecology Journal Vol 6, No 1 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.16-20.2022

Abstract

Introduction: Malaria in pregnancy is still a major cause of neonatal adverse outcome in West Papua, Indonesia. In accordance to the recommendation of the World Health Organization, local government have attempted to prevent malaria in pregnant women by distributing insecticide-treated nets (ITNs). Objective: This study aimed to assess the pattern of malaria infection and the use of ITNs among pregnant women in the city of Manokwari, West Papua, Indonesia.Methods: We recorded all pregnant women who were admitted to the Manokwari District Hospital during May 2017 to April 2018 with malaria. From a total of 335 cases, 125 women agreed to be interviewed on their ITN use at home.Results : Out of a total of 335 cases during the enrolment period, 175 (52%) were found to be infected with Plasmodium falciparum. Chief complaints were fever (28.8%), hyperemesis (25.6%); cephalgia (18.4%); anaemia (15.2%); preterm labor (8.8%) and diarrhoea (3.2%). Only 23.2% of the 125 samples used ITN at home. Most did not have access government-distributed free nets (43.8%); others did not use it due to the foul smell of the nets (17.7%); the heat experienced when sleeping under nets (29.1%); and fear of insecticide side-effect (9.4%). Conclusion: There is suboptimal use of ITN as a preventive measure against malaria in pregnancy in Manokwari, West Papua. Better distribution and other alternative to physical barriers should be considered by the governmentKeywords: Malaria, pregnancy, insecticide-treated net
Gambaran Karakteristik Klinis dan Histopatologi Kanker Ovarium Anak di RSUP Dr. Hasan Sadikin Bandung Haifa Tuffahati; Ali Budi Harsono; Muhammad Alamsyah Aziz; Kemala Isnainiasih Mantilidewi; Febia Erfiandi
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 1 Maret 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n1.354

Abstract

Tujuan: Untuk mengetahui gambaran karakteristik klinis dan histopatologi kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung.Metode: Penelitian ini menggunakan desain penelitian deskriptif. Data dikumpulkan dari rekam medis pasien kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung tahun 2017–2020.Hasil: Terdapat 22 pasien kanker ovarium anak yang sesuai dengan kriteria inklusi dan eksklusi. Ditemukan pasien kanker ovarium anak paling banyak usia 13–18 tahun sebanyak 13 orang (59,1%), stadium klinis I sebanyak 10 orang (45,4%), histopatologi jenis sel germinal sebanyak 17 orang (77%), dan gejala klinis benjolan pada perut sebanyak 16 orang (33%).Kesimpulan: Kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung Bandung periode 1 Januari 2017 – 31 Desember 2020 paling sering terjadi pada pasien dengan rentang usia 13–18 tahun, terdiagnosis pada stadium I, karakteristik histopatologi tipe sel germinal, dan memiliki gejala klinis berupa benjolan pada perut.Overview of Clinical Characteristics and Histopathology of Pediatric Ovarian Cancer at RSUP Dr. Hasan Sadikin Bandung AbstractObjective: To determine pediatric ovarian cancer’s clinical characteristics and histopathology at RSUP Dr. Hasan Sadikin Bandung.Methods: This study used a descriptive research design. Data were collected from medical records of pediatric ovarian cancer patients at RSUP Dr. Hasan Sadikin Bandung in 2017 – 2020.Result: 22 pediatric ovarian cancer patients met the inclusion and exclusion criteria. The majority of pediatric ovarian cancer patients were 13-18 years as many as 13 people (59.1%), clinical stage I as many as 10 people (45.4%), histopathological germ cell types as many as 17 people (77%), and clinical symptoms as lumps in the abdomen as many as 16 people (33%).Conclusion: Pediatric ovarian cancer at RSUP Dr. Hasan Sadikin Bandung period 1 January 2017 – 31 December 2020 most  occurred in patients aged 13–18 years, diagnosed at stage I, histopathological characteristics of germ cell type, and had clinical symptoms in the form of abdominal lump.Key words: Ovary, Pediatric Ovarian Cancer, Clinical Characteristic, Histopathological Characteristic
Apakah Kadar β-hCG Praevakuasi dan Gambaran Proliferasi Sel Trofoblas secara Mikroskopik dapat digunakan untuk Prediksi Transformasi Keganasan pada Mola Hidatidosa? Kemala Isnainiasih Mantilidewi; Zulvayanti Zulvayanti; Wiryawan Permadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1401.032 KB) | DOI: 10.24198/obgynia.v1n1.1

Abstract

AbstrakTujuan: Meneliti perbedaan karakteristik umur, paritas, besar uterus, kadar β-hCG, dan hiperproliferasi pada mola hidatidosa (MH) dengan regresi spontan dan pada MH dengan transformasi keganasan di RS Dr.Hasan Sadikin Bandung. Metode: Penelitian cross sectional deskriptif restrospektif mengambil data umur, paritas, besar uterus, kadar β-hCG pre-evakuasi, dan hiperproliferasi dari rekam medis pasien MH periode 2007-2016. Data diolah menggunakan program SPSS versi 20.0 for Windows. Nilai p<0,05 dianggap signifikan. Hasil: Dari 400 rekam medis yang dianalisis, 233 dengan data lengkap dapat dianalisis. Mayoritas pasien usia reproduktif 20-35(53,6%) tahun, paritas 1-2 (n=90, 38,6%), dan besar uterus rata-rata 19,12±4,633 (~minggu kehamilan). Kadar β-hCG <100000 mIU/mL sebanyak 78(33,5%), ≥100000 mIU/mL sebanyak 155(66,5%). Pasien dengan hiperproliferasi sebanyak 83(35,6%) sedangkan pasien tanpa hiperproliferasi sebanyak 150(64,4%). Terdapat 219(94,0%) dengan komplit MH, dan 14(6,0%) HM parsial (tidak dipublikasi). Pasien kemudian dikategorikan menjadi kelompok transformasi keganasan dan kelompok remisi spontan. Tidak terdapat perbedaan umur, paritas, dan besar uterus diantara dua kelompok (p>0,05). Perbedaan kadar βhCG (mIU/mL) dan tingkat proliferasi menunjukkan hasil signifikan (p<0.05). Kesimpulan: Kadar β-hCG preevakuasi dan status hiperproliferasi dapat digunakan sebagai prediktor transformasi keganasan pasien MH. Can Preevacuation Level β-hCG and Microscopic Trophoblast Proliferation Predict Malignant Transformation in Hydatidiform Mole?AbstractObjective: To describe differences among age, parity, size of uterus, level of β-hCG, and hyperproliferation state in HM with spontaneous remission and in that with malignancy transformation at dr.Hasan Sadikin General Hospital Bandung. Methods: This a cross sectional descriptive restrospective study of HM cases analyzing data on age, parity, size of uterus, pre-evacuation level of β-hCG, and hyperproliferation state taken from medical record of HM patients between 2007-2016. Data were statistically analyzed using SPSS version 20.0 for Windows. Result p<0.05 was considered significant.  Results: Out of 400 cases, 233 cases were selected. Those with incomplete data were not included in the analysis. Majority of patients were in reproductive age 20-35(53.6%) years old, has parity 1-2(n=90, 38.6%), and the size of uterus has mean 19.12±4.633 (~week of pregnancy). The level of β-hCG <100000 mIU/mL was 78(33.5%), ≥100000 mIU/mL was 155(66.5%). Patients with hyperproliferation were 83(35.6%) while without hyperproliferation were 150(64.4%). There were 219(94.0%) with complete HM, and 14(6.0%) partial HM (unpublished data). There were no significant differences in age, parity, size of uterus between the two groups (p>0.05). Differences on level of βhCG (mIU/mL) and proliferation state showed significant result (p<0.05). Conclusion: Preevacuation level of β-hCG and histopatology (proliferation state) may predict malignancy transformation in HM.Keywords: Hydatidiform mole, risk factors, remission, malignancy transformation
Infeksi Luka Operasi pada Kanker Ginekologi Siti Salima; Kemala Isnainiasih Mantilidewi; Ali Budi Harsono
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.425

Abstract

Infeksi luka operasi (ILO) merupakan infeksi pada area operasi yang terjadi dalam waktu 30 hari setelah intervensi bedah. Menurut World Health Organization (WHO), ILO merupakan jenis infeksi nosokomial yang paling sering terjadi pada negara berpenghasilan rendah dan menengah dengan insidensi 11,8 episode per 100 prosedur bedah.1 Infeksi luka operasi dilaporkan terjadi pada 2.6-4.3% pasien yang menjalani operasi.2 Insidensi ILO setelah histerektomi bervariasi mulai dari 1.7-11% tergantung pendekatan operasi, indikasi operasi, dan penggunaan antibiotik profilaksis
Bacteriological Profile and Antibiotic Sensitivity Pattern of Surgical Site Infection Following Gynecologic Oncology Surgery at Hasan Sadikin General Hospital Kemala Isnainiasih Mantilidewi; Ali Budi Harsono; Jessica Kireina; Jaeni Pringgowibowo; Windy Natasya Al Baihaqi
Andalas Obstetrics And Gynecology Journal Vol 6, No 2 (2022): VOL 6, NO2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.122-129.2022

Abstract

Introduction: Surgical site infection (SSI) is the most common complication of gynecologic oncology surgeries. Understanding the characteristics, bacteriological profile, and antibiotic sensitivity pattern of SSI patients can help guide patient’s management and reduce morbidity, mortality, and economic burden caused by SSI. The aim of this study is to describe the characteristics, bacteriological profile, and antibiotic sensitivity pattern of SSI patients following gynecologic oncology surgery at Hasan Sadikin General Hospital Bandung in 2021. Methods: This is a descriptive study that analyzed medical records of patients undergoing gynecologic oncology surgery at Hasan Sadikin Hospital Bandung from January to December 2021. Results: Out of 157 gynecologic oncology surgeries in 2021 that met the criteria, there were 11 incidences of SSI (7%). All SSI patients received postoperative antibiotics, with the most common type of antibiotic given being a combination of ceftriaxone and metronidazole. Ten out of the 11 specimens from SSI patients showed bacterial growth and a total of 17 bacterial isolates were found. Most specimens showed polymicrobial infection with the most common isolate being Escherichia coli Extended-Spectrum Beta-Lactamase (ESBL). Gram-positive bacteria in this study were most sensitive to Vancomycin, Tigecycline, and Gentamicin. Meanwhile, gram-negative bacteria were most sensitive to Ertapenem and Meropenem. Conclusion: Incidence of SSI following gynecologic oncology surgery at Hasan Sadikin General Hospital in 2021 is 7%. The most frequently found isolate was Escherichia coli ESBL. Gram-positive bacteria were most sensitive Vancomycin, Tigecycline, and Gentamicin; while gram-negative bacteria were most sensitive to Ertapenem and Meropenem.
Determinants of Insecticide-treated Net use among Pregnant Women with Malaria in West Papua, Indonesia. Tita Husnita Madjid; Ari Irawan Romulya; Kemala Isnainiasih Mantilidewi; Hadi Susiarno
Andalas Obstetrics And Gynecology Journal Vol 7, No 1 (2023): .
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.1.282-285.2023

Abstract

AbstractObjectiveMalaria in pregnancy is still a major cause of neonatal adverse outcome in West Papua, Indonesia. In accordance to the recommendation of the World Health Organization, local government have attempted to prevent malaria in pregnant women by distributing insecticide-treated nets (ITNs). This study aimed to assess the pattern of malaria infection and the use of ITNs among pregnant women in the city of Manokwari, West Papua, Indonesia.Methods We recorded all pregnant women who were admitted to the Manokwari District Hospital during May 2017 to April 2018 with malaria. From a total of 335 cases, 125 women agreed to be interviewed on their ITN use at home.ResultsOut of a total of 335 cases during the enrolment period, 175 (52%) were found to be infected with Plasmodium falciparum. Chief complaints were fever (28.8%), hyperemesis (25.6%); cephalgia (18.4%); anaemia (15.2%); preterm labor (8.8%) and diarrhoea (3.2%). Only 23.2% of the 125 samples used ITN at home. Most did not have access government-distributed free nets (43.8%); others did not use it due to the foul smell of the nets (17.7%); the heat experienced when sleeping under nets (29.1%); and fear of insecticide side-effect (9.4%). ConclusionThere is suboptimal use of ITN as a preventive measure against malaria in pregnancy in Manokwari, West Papua. Better distribution and other alternative to physical barriers should be considered by the government.
Clinicopathological Characteristics of Cervical Carcinoma with Pelvic Lymph Node Metastases in Dr. Hasan Sadikin General Hospital, Bandung 2013-2021 Henny Sri Rejeki; Sri Suryanti; Anglita Yantisetiasti; Kemala I. Mantilidewi; Gatot Nyarumenteng Adhipurnawan Winarno
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n2.2776

Abstract

Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks first among carcinomas in Indonesia. Lymph node metastasis is a risk of recurrence, affecting survival and therapy. The purpose of this study was to determine the clinicopathological characteristics of cervical carcinoma with pelvic lymph node metastasis that had undergone radical hysterectomy and lymphadenectomy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study used a cross-sectional retrospective descriptive study. Data on the clinical stage I-II cervical cancer patients with pelvic lymph node metastasis were collected  from the archives of the pathological anatomy  laboratory during period from 2013 to 2021. Data were presented in percentage.Results: There were 64 data patients, and the most common age of cervical carcinoma ranged from 40 to 50 years old (52%), the most common stage was stage II (66%), and the most frequent histopathological type was squamous cell carcinoma (70%). The highest degree of differentiation was moderate differentiation (50%). There was no difference in tumor size between sizes <4 cm and ≥4 cm.Conclusion: The cases of cervical carcinoma at Dr. Hasan Sadikin General Hospital Bandung are treated with radical hysterectomy and lymphadenectomy. The patients generally aged between 41–50 years old, stage II, and squamous cell carcinoma with a moderate degree of differentiation.
Characteristics of Referral Patients with Gestational Trophoblastic Neoplasia in Dr. Hasan Sadikin General Hospital Bandung Kemala Isnainiasih Mantilidewi; Aditya Rifandi Zaenudin; Ali Budi Harsono; Anita Deborah Anwar; Jessica Kireina
Indonesian Journal of Cancer Vol 17, No 3 (2023): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i3.990

Abstract

Background: : Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions caused by abnormal trophoblast proliferation and the malignant form is called gestational trophoblastic neoplasia (GTN). Dr. Hasan Sadikin General Hospital, located in Bandung, West Java, is one of the main cancer referral hospitals in Indonesia. Consequently, the characteristics of GTN patients in this hospital can represent the general population in the province. This study aimed to elaborate on the characteristics of referral patients with GTN in Dr. Hasan Sadikin General Hospital.Methods: : Medical records of post-molar GTN patients in Dr. Hasan Sadikin General Hospital from between January 2019 to December 2020 were collected and analyzed. GTN was diagnosed according to the International Federation in Gynecology and Obstetrics (FIGO) criteria. Additionally, both the sociodemographic and clinical characteristics of patients were evaluated.Results:  The results showed that among the 160 participants in this study, the overall mean age was 33±8.7 years, with a mean βhCG level of 241,461.81±630,557.90 mIU/mL. Moreover, approximately 16.3% had gestosis and 5% were diagnosed with hyperthyroidism. The majority of post-molar observations at the hospital were not carried out according to standards, with only 8.1% of patients receiving optimal surveillance. About 56.8% visited the hospital due to vaginal bleeding, while most histopathological results showed complete hydatidiform moles (44.4%), and choriocarcinomas (16.3%). Most of the patients were diagnosed as stage I (81.9%), had lowrisk FIGO scores (80.6%), and were treated with methotrexate (80.6%).Conclusions:  GTN patients in Dr. Hasan Sadikin General Hospital showed clinical characteristics consistent with previous studies. The low percentage of patients receiving optimal post-molar surveillance could cause delayed referral. This suboptimal surveillance might be due to the high cost of βhCG testing, lack of facilities, and low patient compliance in West Java
Co-Authors Aditya Rifandi Zaenudin Alamsyah Aziz Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Anglita Yantisetiasti Anita Deborah Anwar Ari Irawan Romulya Ari Irawan Romulya Febia Erfiandi Gatot Nyarumenteng Adhipurnawan Winarno H Susiarno Hadi Susiarno Haifa Tuffahati HARSONO, ALI BUDI Henny Sri Rejeki Jaeni Pringgowibowo Jessica Kireina Jessica Kireina Siti Salima Sri Suryanti Tita Husnita Madjid Tita Husnita Madjid Windy Natasya Al Baihaqi Wiryawan Permadi Zulvayanti Zulvayanti