Sinaga, Rika Nailuvar
Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Effect of Purple Sweet Potato (Ipomoea Batatas L.) on Reducing Renal Tissue Damage of House Mice (Mus Musculus L.) After Excessive Physical Exercise Sinaga, Rika Nailuvar; Rusmarilin, Herla; Mardiani, T.Helvi; Elvana, Ayu
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Heavy physical exercise can reduce blood flow and metabolism in kidney that eventually release free radicals. The free radicals can form oxydative stress and damage renal tissue. Exogenous antioxydant administration is usually recommended to minimize the renal tissue damage. This study aimed to examined the effect of purple sweet potato (Ipomoiea batatas L.) extract on renal tissue damage  in mice  (mus musculus L.) after heavy physical exercise.Subjects and Method: This was a randomized controlled trial with post test only control design. The study subjects included twenty four male white mice with DD Webster strain. These mice were divided into six groups. After undergoing excessive swimming exercises that lasted forteen days, purple sweet potato extract was given to the experimental group. There were three experimental groups receiving three different doses of purple sweet potato. The mice kidney was taken as sample for microscopic examination to determine the extent of tissue damage. Difference in renal tissue damage was tested by Kruskal-Wallis.Results: Microscopic examination showed statistically significant difference in tissue damage both in right (p=0.001) and left (p=0.036) kidneys, between study groups. The experimental groups showed less damaged than control group.Conclusion: Purple sweet potato (Ipomoiea batatas L) can lessen renal damage in male white mice (Mus musculus L) undergoing excessive physical exercise.Keywords: purple sweet potato (Ipomoiea batatas L), renal tissue damage miceCorespondance: Rika Nailuvar Sinaga. Faculty of Sport Science, Medan University. Email: rikanailuvar890@gmail.comIndonesian Journal of Medicine (2016), 1(1): 76-83https://doi.org/10.26911/theijmed.2016.01.01.10
Effect of Purple Sweet Potato (Ipomoea Batatas L.) Extract on Glutathione Peroxidase (GPx) Activities in Hepatic House Mice (Mus musculus) After Maximum Physical Exercise Elvana, Ayu; Rusmarilin, Herla; Silaban, Ramlan; Sinaga, Rika Nailuvar
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Physical exercise can improve antioxidant defense system of organis. But long and heavy exercise can disrupt the balance of oxidant-antioxidant. Low glutathione peroxidase is associated with free radicals. Plant purple sweet potatoes (Ipomoea batatas L.) contain anthocyanins high enough that act as antioxidants. This stu­dy aimed to determine the effect of extracts of tubers of purple sweet potato (Ipomoea Batatas L.) on the activity of glutathione peroxidase (GPx) liver of mice (Mus Musculus) treated with maximal physical exercise.Subjects and Method: This was a true experimental study. This conducted with the design of the control group post-test only in vivo on 24 white male mice (Mus musculus), DD Webster strain. Da­ta analysis was using SPSS software 19. Statistical testing decision taken 5% significance level (p=0.05). Results: The results showed that the average enzyme activity of GPx in the P5 is the highest enzyme activity GPx (mean=19:39 ± SD=7:06, p=0.024), which means there are significant differ­rences in the enzyme activity of GPx values between groups.Conclusion: This study showed that the extract could increase the activity of GPx hepatic enzyme­es mice significantly.Keywords: physical exercise maximum, free radicals, purple sweet potato, anthocyanin, GPxCorrespondence: Ayu Elvana. School of Health Sciences (STIKes) Siti Hajar, Medan, Indonesia.Indonesian Journal of Medicine (2016), 1(2): 116-120https://doi.org/10.26911/theijmed.2016.01.02.05