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Prasetyastuti, .
Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
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The role of isoflavon in reducing blood glucose levels Prasetyastuti, .
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.744 KB) | DOI: 10.19106/JMedScie/005004201814

Abstract

Plants provide excellent sources of medicinal compounds. Over 5000 flavonoids havebeen isolated and identified from plant sources. Flavonoids are polyphenolic compoundsmainly recognized as pigments which produce the colors found in flowers, fruit and leaves.Dietary polyphenols are commonly found in plants and are abundant in fruit, vegetables,chocolate, and nuts. These polyphenols also found in beverages including tea, coffee,wine, and soy milk. Flavonoids are known to lower glucose levels, decrease cholesteroland triglycerides, and increase liver enzyme levels most likely by stimulating pancreaticinsulin release. By activating cell-signaling pathways involved in controlling blood glucoselevels, flavonoids aid in carbohydrate digestion, and adipose deposition. Flavonoidscontaining isoflavones, flavanols, flavanones, flavonols, flavones, and anthocyaninshave been studied from clinic study until pre clinic study. However, not all of the studiesconducted had adequate results. Isoflavone is one of the potential flavonoids that still canbe explored for future research. Research on isoflavone supplementation in animals andhumans in reducing blood glucose levels is still limited. Short-term supplementation didnot improve blood glucose levels in postmenopausal women, while other studies suggestthat the long-term isoflavone supplementation can reduce postmenopausal blood glucoselevels. These findings found that isoflavone is a component of flavonoids that have potencyin reducing blood glucose levels.
Correlation between ratio of Nrf2/Keap1 and catalase gene expression in liver of hyperlipidemic rats after administration of 7-hydroxy-2-(4-hydroxy- 3-methoxyphenyl)-chromen-4-one Prasetyastuti, .; Rubi, Dianandha Septiana; Pramana, Abrory Agus Cahya; Sadewa, Ahmad Hamim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.702 KB) | DOI: 10.19106/JMedScie/005101201903

Abstract

Hyperlipidemia results in excessive superoxide anion radicals that are the cause ofoxidative stress. Phytochemical compounds can reduce oxidative stress. The aim of thisstudy was to investigate the correlations between ratio of Nrf2/Keap1 and catalase geneexpression in livers of hyperlipidemic rats after administration of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one. Twenty-four Rattus norvegicus rats, aged 8 weeks andweighing an average of 200 g were randomly divided into 6 groups i.e. Group 1 wasnormal group (N), Group 2 was hyperlipidemic rats (HL), Group 3 was hyperlipidemicrats with simvastatin (HL+SV), and Groups 4-6 were hyperlipidemic rats with 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one doses 10 mg (HL+10), 30 mg (HL+30) or 90 mg/200 g BW (HL+90), respectively, administered orally by gavages. At the end ofthe study, the rats were euthanized and the livers were used to analyze the ratio of Nrf2/Keap 1 and catalase gene expression. Nrf2/Keap1 ratio and catalase gene expressionbetween groups were analyzed by Kruskal Wallis test. Spearman’s correlation test wasused to analyze the correlations between Nrf2/Keap1 ratio and catalase gene expression.The administration of 3 different doses of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one on hyperlipidemic rats increased catalase gene expression. There wasno correlation between ratio Nrf2/Keap1 and catalase gene expression. In conclusion,administration of 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chromen-4-one can improvecatalase gene expression in hyperlipidemic rats. However, there is no correlation betweenthe ratio of Nrf2/Keap1 gene expression and the catalase gene expression.
Co-Authors Ahmad Hamim Sadewa Pramana, Abrory Agus Cahya Rubi, Dianandha Septiana