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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
T. Chalid, St. Maisuri
Indonesian Socety of Obstetrics and Gynecology
Health Professions Medicine & Pharmacology Public Health

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 1 
Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment Randabunga, Ervan J; Lukas, Efendi; Tumedia, Josephine L; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.561 KB) | DOI: 10.32771/inajog.v6i4.848

Abstract

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin   Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer. Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35). Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol. Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer. Kata kunci : Dismenore primer, piridoksin, prostaglandin
The Effect of Cyclophosphamide Chemotherapy on Ovarian AntiMüllerian Hormone Levels in Breast Cancer Patients Liga, Elisabeth G.K.; Abdullah, Nusratuddin; Tiro, Eddy; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.105 KB) | DOI: 10.32771/inajog.v6i1.761

Abstract

Objective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.[Indones J Obstet Gynecol 2018; 6-1: 64-67]Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserveObjective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserve
Effect of Artesunate on Peripheral Parasitaemia in Pregnant Women with Plasmodium Falciparum Infection Saragih, Susi W; T. Chalid, St. Maisuri; Malinta, Umar; Wahid, Isra
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.179 KB) | DOI: 10.32771/inajog.v5i3.537

Abstract

Objective: To determine the effect of artesunate on peripheral parasitaemia in pregnant women with Plasmodium falciparum infection. Methods: Pregnant women in second and third trimester with Plasmodium falciparum infection and their newborns were included in cohort prospective study in Sorong West Papua from September 2015 to February 2016. All pregnant women received 200 mg orally artesunate monotherapy for 7 days. Their newborns examined for weight at delivery and parasitaemia in placenta and cord blood. Parasitaemia diagnosis by Rapid Diagnostic Test and blood smear microscopy. Results: After artesunatemonotherapy, 82.5% (33/40) malariainfected pregnant women had negative parasitaemia (p=0.000) although 17.5% (7/40) of the pregnant women had positive parasitaemia. Parasitaemia also found in 10% (4/40) of placenta and 7.5% (3/40) of umbilical cord from newborns of malaria-infected pregnant women treated with artesunate. 70% (28/40) of the newborns in this study had normal weight. Conclusion: Artesunate reduces peripheral parasitaemia in the second and third trimester of pregnancy, and is associated with normal birth weight. [Indones J Obstet Gynecol 2017; 5-3: 135-138] Keywords: artesunate, low birth weight, peripheral parasitaemia
The Effect of Cyclophosphamide Chemotherapy on Ovarian AntiMüllerian Hormone Levels in Breast Cancer Patients Liga, Elisabeth G.K.; Abdullah, Nusratuddin; Tiro, Eddy; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.105 KB) | DOI: 10.32771/inajog.v6i1.761

Abstract

Objective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.[Indones J Obstet Gynecol 2018; 6-1: 64-67]Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserveObjective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserve
Effect of Artesunate on Peripheral Parasitaemia in Pregnant Women with Plasmodium Falciparum Infection Saragih, Susi W; T. Chalid, St. Maisuri; Malinta, Umar; Wahid, Isra
Indonesian Journal of Obstetrics and Gynecology Volume. 5, No. 3, July 2017
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.179 KB) | DOI: 10.32771/inajog.v5i3.537

Abstract

Objective: To determine the effect of artesunate on peripheral parasitaemia in pregnant women with Plasmodium falciparum infection. Methods: Pregnant women in second and third trimester with Plasmodium falciparum infection and their newborns were included in cohort prospective study in Sorong West Papua from September 2015 to February 2016. All pregnant women received 200 mg orally artesunate monotherapy for 7 days. Their newborns examined for weight at delivery and parasitaemia in placenta and cord blood. Parasitaemia diagnosis by Rapid Diagnostic Test and blood smear microscopy. Results: After artesunatemonotherapy, 82.5% (33/40) malariainfected pregnant women had negative parasitaemia (p=0.000) although 17.5% (7/40) of the pregnant women had positive parasitaemia. Parasitaemia also found in 10% (4/40) of placenta and 7.5% (3/40) of umbilical cord from newborns of malaria-infected pregnant women treated with artesunate. 70% (28/40) of the newborns in this study had normal weight. Conclusion: Artesunate reduces peripheral parasitaemia in the second and third trimester of pregnancy, and is associated with normal birth weight. [Indones J Obstet Gynecol 2017; 5-3: 135-138] Keywords: artesunate, low birth weight, peripheral parasitaemia
Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients Akbar, Willy; Rauf, Syahrul; S. Riu, Deviana; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (61.295 KB) | DOI: 10.32771/inajog.v7i1.817

Abstract

Abstract Objective : To determine the conformity of HPV type 16 and 18 in cervical and oral/buccal specimens from cervical cancer patients. Methods :A cross-sectional study was conducted in March - September 2016 at several hospitals in Makassar. HPV 16 and 18 genotyping in cervical and oral fluid of 77 patients with cervical cancer performed with PCR method. Results : The prevalence of HPV type 18 infection both in the cervical and the oral fluid was higher than HPV type 16 [9(47.4%) vs 5(26.3%)]. The aggreement of HPV type 18 infection (r=0.328;p=0.000) in the cervical-oral sites was higher than HPV type 16 (r=0.194;p=0.042). Conclusion : HPV type 16 and 18 could infect both cervix and oral cavity although type-specific concordance is low. Keywords :Human papillomavirus,servix, oral cavity   Abstrak Tujuan: Mengetahui tingkat kesesuaian hasil pemeriksaan HPV tipe 16 dan 18 antara spesimen serviks dan oral/buccal pada penderita kanker serviks. Metode: Penelitian cross sectional ini dilakukan pada Maret – September 2016 pada beberapa rumah sakit di Makassar. Pemeriksaan HPV 16 dan 18 pada cairan serviks dan oral dari 77 orang penderita kanker serviks menggunakan teknik PCR. Hasil: Prevalensi infeksi bersama pada serviks dan oral HPV tipe 18 lebih tinggi dibandingkan HPV tipe 16 [9(47,4%) vs 5(26,3%)]. Tingkat kesesuaian antara HPV tipe 18 (r=0,328;p=0,000) pada serviks dan oral lebih tinggi dibandingkan tipe 16 (r=0,194;p=0,042). Kesimpulan: HPV tipe 16 dan 18 dapat menginfeksi serviks dan oral meskipun tingkat kesesuaian kedua tipe ini lemah. Kata kunci : Human papillomavirus, serviks, kavum oral
Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment Randabunga, Ervan J; Lukas, Efendi; Tumedia, Josephine L; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.561 KB) | DOI: 10.32771/inajog.v6i4.848

Abstract

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin   Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer. Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35). Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol. Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer. Kata kunci : Dismenore primer, piridoksin, prostaglandin
Co-Authors Akbar, Willy Eddy Tiro Efendi Lukas Isra Wahid Josephine L Tumedia Liga, Elisabeth G.K. Nusratuddin Abdullah Randabunga, Ervan J S. Riu, Deviana Saragih, Susi W Syahrul Rauf Umar Malinta