Siti Setianingsih
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Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Setianingsih, Siti; Nurani, Laela Hayu; Rohman, Abdul
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.336 KB) | DOI: 10.12928/pharmaciana.v8i2.8738

Abstract

Kelopak bunga rosella (Hibiscus sabdariffa L.) memiliki kandungan flavonoid terutama antosianin dan quersetin yang berpotensi sebagai antioksidan, hepatoprotektor, diuretik, antikolesterol serta imunostimulator. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian serta keamanan ekstrak etanol kelopak bunga rosella merah selama 30 hari dan selama 15 hari setelah tidak mengkonsumsi rosella terhadap nilai hematokrit, trombosit dan eritrosit. Penelitian ini menggunakan rancangan pre-post treatment design study. Dua puluh satu sukarelawan sehat digunakan dalam penelitian yang telah memenuhi kriteria inklusi dan eksklusi serta bersedia mengisi informed consent. Sukarelawan diberikan kapsul dengan dosis 500 mg sebanyak 1 kali sehari, 10-15 menit setelah makan pada malam hari selama 30 hari. Pemeriksaan hematologi dilakukan pada hari ke-0; 31; dan 45 yang meliputi parameter hematokrit, trombosit, dan eritrosit menggunakan hematology analyzer. Hasil yang diperoleh dibandingkan secara statistik menggunakan paired t test dan wilcoxon test. Hasil rerata hematokrit, trombosit, dan eritrosit pada sukarelawan laki-laki dan perempuan hari ke-0, hari ke-31 dan hari ke-45 masuk dalam rentang normal. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna (p>0,05) nilai hematokrit, trombosit dan eritrosit perbandingan hari ke-0 dengan hari ke-31, hari ke-31 dan hari ke-45, serta hari ke-0 dan hari ke-45. Pemberian kapsul ekstrak etanol rosella merah 500 mg selama 30 hari dan setelah 30 hari tidak mengkonsumsi kapsul ekstrak etanol rosella tidak mempengaruhi semua parameter hematologi pada sukarelawan sehat.
Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Siti Setianingsih; Laela Hayu Nurani; Abdul Rohman
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.858 KB) | DOI: 10.12928/pharmaciana.v8i2.8738

Abstract

Roselle calyx (Hibiscus sabdariffa L) is widely used as an antioxidant, antihepatotoxic, diuretic, anti-cholesterol, and immunostimulant. Roselle contains anthocyanin and quercetin that have antioxidant activity. This study aimed to determine the effects of the ethanolic extract of roselle calyx on hematocrit, platelets, and erythrocytes in healthy volunteers during the 30-day administration and 15 days after it ceased. This study employed pre- and post-treatment design on 21 healthy volunteers, comprising 11 males and 10 females who fulfilled the inclusion criteria and filled out the informed consent form willingly. Volunteers were provided with roselle capsules for 30 days with a dosage of 500 mg a day taken 10-15 minutes after dinner. The hematologic examination was performed on Day 0, 31, and 45, including the measurement of hematocrit, platelet, and erythrocyte levels using a hematology analyzer. The obtained data were analyzed in SPSS with paired t-test and Wilcoxon test. The results showed that the hematocrit, platelets, and erythrocytes of all male and female volunteers on Day 0, 31, and 45 were within the normal range. The comparison analysis affirmed that there was no significant difference between these three parameters from Day 0 to 31, Day 31 to 45, and Day 0 to 45 (p>0.05). As a conclusion, the administration of the ethanolic extract of roselle calyx with a dosage of one 500mg capsule per day for 30 days did not affect the hematocrit, platelets, and erythrocytes in healthy volunteers. There was also no delayed effect on these three hematological parameters 15 days after the administration stopped.