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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology JRST (Jurnal Riset Sains dan Teknologi) Prosiding Seminar Nasional Hasil-hasil Penelitian dan Pengabdian Pada Masyarakat
Shintia Lintang Charisma
Universitas Muhammadiyah Purwokerto
Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Medicine & Pharmacology Public Health Social Sciences

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Determination of Sun Protection Factor and Antioxidant Properties of Cream Formulation of Kencur (Kaempferia galanga L) and Temu Kunci (Boesenbergia pandurata (Roxb.) Schlecht) Rhizomes Extract Charisma, Shintia Lintang; Rahayu, Wiranti Sri; Wahyuingrum, Retno
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.191 KB) | DOI: 10.12928/pharmaciana.v8i2.11891

Abstract

Kencur (Kaempferia galanga, L.) rhizome contain ethyl-p-methoxycinnamate (EPMS) which has sunscreen properties. Temu kunci (Boesenbergia pandurata (Roxb) Schlecht) rhizome contains  flavonoid and essential oils with oxidant radical scavenging properties. The aims  of this study were  to obtain the optimum physical properties of sunscreen and antioxidant cream and to compare the sun protection factor (SPF) values and antioxidant activity of kencur and temu kunci rhizomes extract before and after formulated.This research used Simplex Latice Design (SLD) model with 2 components of kencur extract and temu kunci extract. Based on the SLD model obtained optimum formula design, then the SPF values and antioxidant activity were studied by UV spectrophotometric method and DPPH method respectively.Based on SLD model obtained optimum formula that containing kencur : temu kunci extract 80%:20% (formula A) and 70%:30% (formula B). The SPF values of  kencur extract, formula A and formula B were  4.505, 5.024 and 4.511 respectively. Antioxidant activity showed that the IC50 of formula A, formula B, temu kunci extract, BHT and Vitamin E were 109.15 µg/ml, 95.23 µg/ml, 10.20 µg/ml, 22.33 µg/ml and 8.78 µg/ml respectively.Cream formula A and formula B have optimum physical properties. The SPF value of the optimum formulations were higher than SPF value of kencur extract. Antioxidant activity of that combinations were  lower than temu kunci extract, BHT and Vitamin E.
Formulation of Cinchona Extract (Cinchona succirubra) Cream and The Safety as Hair Fertilizer Hariyanti Hariyanti; Retno Wahyuningrum; Shintia Lintang Charisma
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36324

Abstract

Background: cinchona extract contains quinoline alkaloids, has telangiectatic activity, is practically insoluble in water so penetration into hair follicles is low and requires a delivery system, namely cream. Objective: to determine the formula of cinchona extract cream with good activity, physical stability and safety. Methodology: cinchona bark extraction (soxhletation method), phytochemical screening, cinchona extract dosage determination, optimization of cream formula using Design Expert software version 11. Evaluation: pH, adhesion, spreadability, viscosity and cycling test stability. Activity test using guinea pigs (Cavia porcellus) for 14 days, parameters of hair length/2 days, hair mass (14th day). Acute dermal irritation test using rabbit (Orycogalus cuniculus) by erythema and edema index parameters. Results: cinchona extract (13.32% yield) contained quinoline alkaloids, cinchona extract dosage was 20% (p<0.05). The optimum formula is F2 with characteristics: pH 6.48±0.07, adhesion 1.16±0.07, spreadability 4.99±0.85 and viscosity 3067±416.45, has good physical stability. Activity test: test area hair length 13.54 – 62.14% longer than normal control and 10.10 – 49.17% than negative control. The hair mass of test area was 122.91% heavier than normal control and 104.48% of negative control (p<0.05). Cinchona extract and excipients were non-irritant. Conclusion: Cinchona extract cream (20%) has hair fertilizer activity, good physical stability and safety.
Determination of sun protection factor and antioxidant properties of cream formulation of kencur (Kaempferia galanga L) and temu kunci (Boesenbergia pandurata (Roxb.) Schlecht) rhizomes extract Shintia Lintang Charisma; Wiranti Sri Rahayu; Retno Wahyuingrum
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.191 KB) | DOI: 10.12928/pharmaciana.v8i2.11891

Abstract

Kencur (Kaempferia galanga, L.) rhizome contain ethyl-p-methoxycinnamate (EPMS) which has sunscreen properties. Temu kunci (Boesenbergia pandurata (Roxb) Schlecht) rhizome contains flavonoid and essential oils with radical scavenging properties. The aims of this study were to obtain the optimum physical properties of sunscreen and antioxidant cream and to compare the sun protection factor (SPF) values and antioxidant activity of kencur and temu kunci rhizomes extract before and after formulated. This research used Simplex Latice Design (SLD) model with 2 components of kencur extract and temu kunci extract. Based on the SLD model obtained optimum formula design, then the SPF values and antioxidant activity were studied by UV spectrophotometric method and DPPH method respectively. Based on SLD model obtained optimum formula that containing kencur : temu kunci extract 80%:20% (formula A) and 70%:30% (formula B). The SPF values of kencur extract, formula A and formula B were 4.505, 5.024 and 4.511 respectively. Antioxidant activity showed that the IC50 of formula A, formula B, temu kunci extract, BHT and Vitamin E were 109.15 μg/mL, 95.23 μg/mL, 10.20 μg/mL, 22.33 μg/mL and 8.78 μg/mL respectively. Cream formula A and formula B have optimum physical properties. The SPF value of the optimum formulations were higher than SPF value of kencur extract. Antioxidant activity of that combinations were lower than temu kunci extract, BHT and Vitamin E.
PELATIHAN PENCEGAHAN DAN PENGOBATAN PENYAKIT DEGENERATIF DENGAN JAMU SAINTIFIK PADA KADER AISYIAH DESA PAMIJEN Zainur Rahman Hakim; Shintia Lintang Charisma; Melawati Melawati; Chazma AlFikri
PROSIDING SEMINAR NASIONAL LPPM UMP Vol 2 (2020): PROSIDING SEMINAR NASIONAL LPPM UMP 2020
Publisher : Lembaga Publikasi Ilmiah dan Penerbitan (LPIP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.911 KB)

Abstract

Dinas kesehatan Kabupaten Banyumas mencatat bahwa di wilayah Kecamatan Sokaraja ditemukan 30 kasus pasien yang mengalami diabetes dan 199 kasus hipertensi dibanding dengan data Dinas Kesehatan Jawa Tengah sebanyak 603.840 kasus. Kementerian Kesehatan melalui Badan Penelitian dan Pengembangan Kesehatan menjalankanprogram saintifikasi jamu (SJ) telah membuktikan khasiat jamu dengan metode penelitian berbasis pelayanan. Tujuan dari pengabdian kepada masyarakat ini yaitu untuk memberikan pemahaman kepada masyarakat tentang penyakit degeneratif dan memberikan keterampilan pembuatan jamu saintifik oleh kader Aisyiyah Desa Pamijen, Kecamatan Sokaraja, Kabupaten Banyumas. Metode yang digunakan dalam pengabdian kepada masyarakat ini yaitu melalui metode diskusi. Peserta akan diberikan materi penyakit degeneratif dan terapinya dengan obat tradisional, lalu dilanjutkan dengan pembuatan jamu saintifik untuk terapi penyakit degeneratif. Hasil dari kegiatan dengan judul “pelatihan pencegahan dan pengobatan penyakit degeneratif dengan jamu saintifik kader Aisyiyah desa pamijen” ini mampu meningkatkan pengetahuan masyarakat akan jamu sebagai pengobatan yang terbukti secara ilmiah dengan cara pembuatan yang mudah dilakukan ditunjukan dengan antusiasme masyarakat yang hadir dalam kegiatan ini. Penggunaan jamu saintifik penting untuk menekan potensi peningkatan penderita penyakit asam urat pada warga muhammadiyah dan sekitarnya.
Karakter Mutu Simplisia dan Ekstrak Tumbuhan Antidiabetes Lokal dari Banyumas Dwi Hartanti; Shintia Lintang Charisma; Hidayah Anisa Fitri; Fitriani Fitriani; Denia Awanda Putri; Jeri Rinawati; Widya Agustina; Alwani Hamad
JRST (Jurnal Riset Sains dan Teknologi) Volume 6 No. 2 September 2022: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1182.108 KB) | DOI: 10.30595/jrst.v6i2.15545

Abstract

Daun mindi (Melia azedarach L.), buah kersen (Muntingia calabura L.), serta daun dan bunga tapakdara (Catharanthus roseus (L.) G.Don) digunakan masyarakat Baturraden dan Sumbang (Banyumas) untuk pengobatan tradisional diabetes. Penelitian ini mengkarakterisasi beberapa parameter mutu simplisia dan ekstrak ketiga tumbuhan tersebut.  Simplisia dibuat dari bahan tumbuhan yang dikumpulkan dari tiga desa di wilayah kecamata Baturraden dan Sumbang. Morfologi makroskopik dan mikroskopik, profil kromatografi lapis tipis (KLT), kadar fenolik total, dan kadar flavonoid total simplisia, serta kadar air, kadar abu total, dan kadar abu tidak larut asam ekstrak dianalisis dengan metode standar dalam Farmakope Herbal Indonesia (FHI) 2017. Karakter makroskopik, fragmen diagnostik, dan profil KLT dari simplisia hasil penelitian ini diusulkan untuk menjadi standar dalam memastikan kebenaran identitas simplisia. Kadar fenolik total dan kadar flavonoid total simplisia daun mindi, buah kersen, serta daun dan bunga tapakdara masing-masing sebesar 0,74±0,07 dan 0,99±0,31; 1,62±0,36 dan 1,39±0,11; dan 0,94±0,02 dan 1,98±0,04%. Nilai tersebut diusulkan sebagai standar untuk aspek kandungan masing-masing simplisia. Data kadar air, kadar abu total, dan kadar abu tidak larut asam diusulkan sebagai standar aspek kemurnian dari masing-masing ekstrak.
Co-Authors Alwani Hamad Chazma AlFikri Denia Awanda Putri Dwi Hartanti Fitriani Fitriani Hariyanti Hariyanti Hidayah Anisa Fitri Jeri Rinawati Melawati Melawati Retno Wahyuingrum Retno Wahyuningrum Wahyuingrum, Retno Widya Agustina Wiranti Sri Rahayu Zainur Rahman Hakim