Jurnal Ilmu Dasar
Vol 21 No 1 (2020)

Optimization of Povidone K-30 and Sodium Starch Glycolate on Levofloxacin Tablet by Factorial Design

Dwi Setyawan (Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga)
Widji Soeratri (Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga)
Mahrus Naufal Nuruddin (Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga)
Diajeng Putri Paramita (Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga)
Bambang Widjaja (Department of Pharmacy, Medical Faculty, Universitas Hang Tua)



Article Info

Publish Date
21 Jan 2020

Abstract

The aim of this study was to determine the effect of binder and disintegrant excipients toward tablet properties of levofloxacin as the latter tends to suffer brittle fracture upon compression. The excipients used were povidone K-30 as the binder and sodium starch glycolate (SSG) as the disintegrant which the tablets were formulated according to factorial design 22 with two factors and two levels on each factor. Four formulas were prepared by wet granulation method using 2 and 4% of each povidone K-30 and sodium starch glycolate in various compositions. Tablet properties were evaluated for its hardness, friability, and disintegration time as well as dissolution profile. The data obtained was statistically analyzed using MinitabĀ® 17 software to optimize the formulation and resulted in different impacts caused by each excipient. Povidone K-30 exhibited an increment in hardness, friability, disintegration time but a decrease indissolution profile of levofloxacin tablet. SSG decreased hardnessand disintegration time, but increased friability and dissolution profile of levofloxacin tablet. Overlaid contour plot showed that the optimal formula regarding tablet properties of friability, disintegration time, and dissolution profile is in composition of 2.01% povidone K-30 and 2.01% sodium starch glycolate. Keywords: levofloxacin tablet, povidone K-30, sodium starch glycolate, factorial design.

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Journal Info

Abbrev

JID

Publisher

Subject

Control & Systems Engineering Mathematics

Description

Jurnal ILMU DASAR (JID) is a national peer-reviewed and open access journal that publishes research papers encompasses all aspects of natural sciences including Mathematics, Physics, Chemistry and Biology. JID publishes 2 issues in 1 volume per year. First published, volume 1 issue 1, in January ...