FITOFARMAKA: Jurnal Ilmiah Farmasi
Vol 2, No 1 (2012): FITOFARMAKA

HISTOPATOLOGI HATI MENCIT PASCA PEMBERIAN SUSPENSI KEPEL (Stelechocarpus burahol) SECARA INTRAGASTRIK SELAMA 14 HARI The Histopathology of Mice Liver Treated by Kepel (Stelechocarpus burahol) Suspension Intragastrically for 14 days

Eva Harlina (Bagian Patologi, Departemen Klinik Reproduksi dan Patologi, FKH IPB,)
Siti (Bagian Farmakologi dan Toksikologi, Departemen Anatomi,Farmakologi dan Fisiologi, FKH IPB,)
Huda S Darusman (Bagian Farmakologi dan Toksikologi, Departemen Anatomi,Farmakologi dan Fisiologi, FKH IPB,)
Gita Alvernita (Fakultas Kedokteran Hewan IPB)

Article Info

Publish Date
01 Jun 2012

Abstract

This aim of this study was to examine the effect of Kepel (Stelechocarpus burahol) to the mice hepatocytes. Thirty male mice of 4 week aged were divided into three groups;control group was treated by aquadest, Dose 1x group was treated by 2.6 mg/g BW/daykepel powder (0.5 ml kepel suspension/day), and Dose 5x group was treated by 13 mg/gBW/day kepel powder (1.0 ml kepel suspension/day). The treatment was intragastricallyfor 14 days. The mice were euthanized and necropsy followed by the liver collection forhistopathology assay. The histopathological examination of liver showed hydropicdegeneration, cell death and extramedullary hematopoietic observed on mice hepatocytes.The ANOVA analysis showed that kepel caused increase significantly (p0.05) ofhydropic degeneration and decrease significantly (p0.05) of cell death of micehepatocytes.Key words: Stelechocarpus burahol, hydropic degeneration, cell death, extramedullary hematopoietic

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Journal Info
FITOFARMAKA: Jurnal Ilmiah Farmasi
Website

Abbrev

fitofarmaka

Publisher

Universitas Pakuan

Subject

Chemistry Medicine & Pharmacology

Description

FITOFARMAKA mempublikasikan artikel yang berkaitan dengan farmasi, Kimia Farmasi, dan bidang Fitokimia serta akan dipublikasikan secara online. Publikasi secara elektronik akan menambah kekayaan informasi dan pengetahuan ilmiah terutama dari penelitian. Jurnal ini diterbitkan dua kali setahun, ...