Farmaka
Vol 17, No 1 (2019): Farmaka (Supplemen)

AKTIVITAS BERBAGAI TANAMAN SEBAGAI ANTIHIPERURISEMIA

KHOIRINA NUR SA'IDAH (260110160054)
Sri Adi Sumiwi (Unknown)



Article Info

Publish Date
28 Jan 2020

Abstract

Abstrak Gangguan metabolik merupakan gangguan peningkatan kadar asam urat (hiperurasemia) penyakit ini sudah sering dijumpai baik di negara Indonesia ataupun negara lainnya di benua Asia. Obat golongan xantin oksidase inhibitor seperti alopurinol dan febuxostat direkomendasikan sebagai lini pertama untuk pengobatan, tetapi perlu diperhatikan penggunaan xantin oksidase yang terus menerus dapat menyebabkan efek samping toksisitas pada gastrointestinal dan meningkatkan serangan akut gout pada awal terapi. Oleh karena itu, banyak penelitian yang melibatkan banyak tumbuhan herbal yang diharapkan memiliki aktivitas antihiperurisemia karena tanaman herbal memiliki resiko toksisitas dan efek samping yang lebih rendah. Berdasarkan penelitian yang telah dilakukan jahe merah (Zingiber officinale var. Amarum), daun salam (Syzygium polyanthum), Herba Suruhan (Peperomia pellucida (L.) Kunth), Meniran (Phyllanthus niruri Linn.) , kayu secang (Caesalpinia sappan L.) , Ekstrak Rebung (Schizostachyum brachycladum Kurz ), Pakis tangkur (Polypodium feei), Naga Putih (Hylocereus undatus), (Mimosa pudica L. ), Daun Sirsak (Annona muricata L.), Sparattosperma leucanthum , Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.), Kulit Buah Manggis (Garcinia mangostana L.), Dioscorea tokoro makino, dan chatupatika memiliki aktivitas antihiperurisemia. Oleh karena itu, pada review ini akan dibahas aktivitas antihiperurisemia pada lima belas tanaman tersebut. Hasil yang didapatkan dari beberapa artikel yaitu beberapa tanaman tersebut berkhasiat sebagai antihyperurisemia melalui uji daya hambat xantin oksidase dan menurunkan kadar asam urat pada hewan uji. Sehingga memiliki potensi yang dapat dikembangkan sebagai obat untuk hyperurisemia. Kata Kunci: Hiperurisemia, Xantin Oksidase, Tanaman Herbal AbstractMetabolic disorders that affect the increase in uric acid levels (hyperurasemia) are diseases that have often been found in both Indonesia and other countries in the Asian continent. Xanthine oxidase inhibitors such as allopurinol and febuxostat are recommended as a first line for treatment, but it should be noted that the continued use of xanthine oxidase can cause gastrointestinal toxicity side effects and increase acute attacks of gout at the beginning of therapy. Therefore, many people use medicinal plants as anti gout because they have relatively small side effects, are easy to obtain, and are relatively inexpensive compared to synthetic drugs. Based on the research, red ginger (Zingiber officinale var. Amarum), bay leaf (Syzygium polyanthum), Suruhan Herb (Peperomia pellucida (L.) Kunth), Meniran (Phyllanthus niruri Linn.) , secang wood (Caesalpinia sappan L.), Bamboo Shoot Extract ( Schizostachyum brachycladum Kurz), Pakis tangkur (Polypodium feei), White Dragon (Hylocereus undatus), (Mimosa pudica L.), Soursop leaf (Annona muricata L.), Sparattosperma leucanthum, Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.), Kulit Buah Manggis (Garcinia mangostana L.), Dioscorea tokoro makino, and chatupatika have antihyperuricemia activities. Therefore, this review will discuss the antihyperuricemia activity in these fifteen plants. The results obtained from several articles, namely some of these plants are efficacious as antihyperurisemia through the inhibitory test of xanthine oxidase and reduce uric acid levels in test animals. So that it has the potential that can be developed as a medicine for hyperurisemia. Keywords: Hyperuricemia, Xanthine Oxidase, Herbal Plants

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Journal Info

Abbrev

farmaka

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Description

Farmaka is replacement for Pharmaceutical Bulletin, published since 1991, with a frequency of four times a year. Editors accept scholarly works of research results and literature review which was closely related to the science, pharmaceutical technology and ...