Medical Journal of Indonesia
Vol 17, No 2 (2008): April-June

Short-term intravenous zoledronic acid in severe osteogenesis imperfecta : A report of three siblings of children

Lim, Hadyanto (Unknown)
Zein, Umar (Unknown)
Siregar, Yahwardiah (Unknown)
Marpaung, Blondina (Unknown)
Sinaga, Jaminsen (Unknown)

Article Info

Publish Date
01 May 2008

Abstract

This report documented the clinical and biochemical side effects on the first dose of intravenous zoledronic acid therapy in three siblings with severe osteogenesis imperfecta. Zoledronic acid was administered in 50 ml 0.9% saline solution over a period of 30 minutes. All patients had fever during the first 6 to 48 hours after the first infusion. There were no renal side effects, apart from asymptomatic hypocalcemia and hypophosphatemia at 48 and 72 hours after zoledronic acid infusion. The minimal clinical side effects were easily manageable. (Med J Indones 2008; 17: 127-30)Keywords: zoledronic acid, osteogenesis imperfecta, side effects

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Journal Info
Medical Journal of Indonesia
Website

Abbrev

MJI

Publisher

Universitas Indonesia

Subject

Medicine & Pharmacology

Description

This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global ...