Communications in Science and Technology
Vol 5 No 1 (2020)

A mini review on production of pluripotency factors (Oct4, Sox2, Klf4 and c-Myc) through recombinant protein technology

David Septian Sumanto Marpaung (Institut Teknologi Sumatera)
Ayu Oshin Yap Sinaga (Institut Teknologi Sumatera)



Article Info

Publish Date
02 Jul 2020

Abstract

The four transcription factors OCT4, SOX2, KLF4 and c-MYC are highly expressed in embryonic stem cells (ESC) and their overexpression can induce pluripotency, the ability to differentiate into all cell types of an organism. The ectopic expression such transcription factors could reprogram somatic stem cells become induced pluripotency stem cells (iPSC), an embryonic stem cells-like. Production of recombinant pluripotency factors gain interests due to high demand from generation of induced pluripotent stem cells in regenerative medical therapy recently. This review will focus on demonstrate the recent advances in recombinant pluripotency factor production using various host.

Copyrights © 2020






Journal Info

Abbrev

cst

Publisher

Subject

Engineering

Description

Communication in Science and Technology [p-ISSN 2502-9258 | e-ISSN 2502-9266] is an international open access journal devoted to various disciplines including social science, natural science, medicine, technology and engineering. CST publishes research articles, reviews and letters in all areas of ...