Journal of Dentomaxillofacial Science
Vol. 5 No. 2 (2020): (Available online: 1 August 2020)

Effects of 15 mg meloxicam administered before odontectomy on pain, facial edema, trismus, and expressions of TNF following odontectomy of impacted mandibular third molar

Melisa Ruth (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia)
Cahya Y. Hasan (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia)
Rahardjo (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gadjah Mada University,Yogyakarta, Indonesia)
Rustamadji Rustamadji (Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing Gadjah Mada University, Yogyakarta, Indonesia)



Article Info

Publish Date
01 Aug 2020

Abstract

Objective:To evaluate the effects of 15 mg meloxicam administered 60 minutes before odontectomy on pain, facial edema, trismus and expressions of TNF-α after odontectomy of impacted mandibular third molar.Material and Methods: A total of 24 patients were randomized into treatment groups, each with 12 patients: Group A was administered with 15 mg of meloxicam; and Group B with placebo. Drugs were administered orally 60 minutes prior to surgery. Observation of pain (seen from VAS scores), facial edema (seen from swollen cheeks), trismus (seen from mouth opening) and expressions of TNF-α (measured from saliva by ELISA method), performed before odontectomy, H+1 (24 hours after odontectomy) and H+3 (72 hours after odontectomy).Results: Patients who received 15 mg meloxicam 60 minutes before odontectomy showed less postoperative pain (p=0.000), less facial edema (p=0.000) and lower expressions of TNF-α (p=0.000). No differences were found in mouth opening between the meloxicam group and placebo group (p=0.522). The higher level of TNF-α level will lead to higher level of pain, greater facial edema and causes smaller mouth opening.Conclusion: Oral administration of 15 mg meloxicam 60 minutes prior to odontectomy was found more effective in reducing pain, facial edema and expressions of TNF-α after odontectomy of impacted mandibular third molar compared with placebo.

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Journal Info

Abbrev

jdmfs

Publisher

Subject

Dentistry

Description

Journal of Dentomaxillofacial Science (J Dentomaxillofac Sci) is an international, peer-reviewed, and open access journal published in English language. Our journal aims to keep dentists informed of developments and advances in general dentistry and its different specialties in an easy-to-read ...