A B S T R A C TIntroduction Psilocybe mushroom, or widely known as the magic mushroom is avariety of mushroom commonly consumed because of hallucinogenic traits it causestoward its consumer. This hallucinogenic effect is caused by Psilocybin, ahallucinogenic substance often found within Psilocybe mushroom. This substanceaffects mental state of the consumer and has similar effect to those of LSD andMescaline. Aside from its effect to cause mental disturbance, consumption of thismushroom may cause acute renal injury which leads to a fatal and life-threateningsituation.Case presentation: A case of Psilocybe intoxication had been reported in a22 years old male with a confirmed history of consuming Psilocybe mushroom. Patientfirst came with a symptom of disorientation and restlessness. Patient also often shookhis head off, laughed out, screamed, and continuously making bizarre movements.Psychiatric examination confirmed a sign of auditory hallucination, unstable mood,and stereotypical behavior experienced by the patient. Conclusion: An approach isneeded in the form of a physical examination and support that supports a promptand precise diagnosis, as well as comprehensive management that focuses on thedirect management of life-threatening symptoms and symptomatic treatment, takinginto account the signs and symptoms of life-threatening nephrotoxicity
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