Abstract: One of the traditional plants used as painkillers or analgesics is soursop leaves because of the content of the alkaloid chemical, tannins. Pain is a disturbing and uncomfortable condition for the sufferer, but pain can be used as a sign of tissue damage. Pain caused by mechanical, chemical or physical stimuli (heat, electricity) can cause tissue damage. This study aims to determine the effect of soursop leaf ethanol extract as an analgesic and prove that soursop leaf ethanol extract can reduce the amount of stretching in mice induced with acetic acid. This research is an experimental research. With variations in the ethanol extract of soursop (Annona muricata L.) leaves in mice. The analysis was carried out by observing organoleptic extracts and the amount of stretching caused after acetic acid induction and% analgesic power. Data analysis techniques using the ANOVA one-way test with the help of the SPSS program. The ethanol extract of Soursop leaves has analgesic effect. The results of the Post Hoc Test (LSD) analysis between positive control (acetosal) 65 mg / kgBW, Soursop leaf extract 1.5 g / kgBW, 3 g / kgBW showed significant values 0.0001
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