<![CDATA[Research on molecular dynamics analysis of the influence of body temperature on HSA fluid volume balance using the Lennard-Jones potential model with temperature variations of 35 ℃, 37 ℃, and 40 ℃ in the form of cubic systems in GROMACS applications. The results show that the denaturation of HSA that is affected by body temperature causes changes in osmotic pressure in the body with changes in the balance of HSA fluid volume. At temperatures of 35 ℃ denaturations occurs Thr566 to Gln580 with a distance of 20.9 A, Lys444 to Met446 with a distance of 5.76 A, Asn61 to Cys62 with a distance of 3.9 A, Glu570 to Ser579 with a distance of 18.09 A, and Gly431 to Cys438 with a distance of 11.43 A. At a temperature of 37 ℃ denaturations occurs Ile513 to Cys514 has a distance of 3.75 A, Pro303 to Glu311 has a distance of 12.78 A, Asn267 to Ser270 has a distance of 4.65 A, Leu275 to Cys279 has a distance of 7 A At a temperature of 40 ℃ denaturations occurs Ser304 to Glu311 with a distance of 11.38 A, Asn267 to Ile271 with a distance of 7.75 A, Asn61 to Cys62 with a distance of 3.9 A, and Ala511 to Cys514 with a distance of 4.86 A. RMSD results shows that stable structural changes occur in HSA with values of 2.6–9.0 nm. And the Lennard-Jones average energy yield shows that the interaction behavior between HSA atoms is dynamic. At a temperature of 35 ℃ of 7.97E + 05 kJ/mol, a temperature of 37 ℃ of 6.78 kJ/mol, and a temperature of 40 ℃ of 7.89E + 05 kJ/mol.]]>
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