The application of physics, in particular, the topic of differential equations is commonly used in mathematics, physics, engineering, and various other sciences to explain a phenomenon in a system, to produce a form of simulation and prediction of a fairly good mathematical equation is needed. This paper examines the use of MATLAB / Simulink to assist in modeling the solution of the differential equation problems by providing a case of mathematical modeling in the analysis of the COVID-19 plague in Indonesia in 2020 with the modification of the Bernoulli equation. In this study, it can be concluded that MATLAB / Simulink can be used to solve differential equation problems with Bernoulli's modification in the case of COVID-19 plague modeling quite accurately.
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