Neurologico Spinale Medico Chirurgico
Vol 3 No 2 (2020)

Correlation of total ischemic time to creatinine serum level and resistive index value in kidney transplant

Putu Astri Novianti (Surgery Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar, Bali-Indonesia)
Gede Wirya Kusuma Duarsa (Urology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali-Indonesia)
Gede Andi Aditya (Faculty of Medicine, Udayana University, Denpasar, Bali-Indonesia)
Anak Agung Gde Oka (Urology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali-Indonesia)
Kadek Budi Santosa (Urology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali-Indonesia)
I Wayan Yudiana (Urology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali-Indonesia)
Pande Made Wisnu Tirtayasa (Urology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali-Indonesia)
Ida Bagus Putra Pramana (Urology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali-Indonesia)
Yenny Kandarini (Nephrology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar, Bali-Indonesia)
Wayan Sudana (Nephrology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar, Bali-Indonesia)
Djodi Sidartha (Nephrology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar, Bali-Indonesia)
Raka Widiana (Nephrology Department, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar, Bali-Indonesia)



Article Info

Publish Date
22 Jul 2020

Abstract

Background: The transient period when the kidney donor was extracted until being anastomosed (total ischemic time) will aggravate many putative molecular ischemic-reperfusion injury mechanisms. Several studies have reported the risk of delayed graft function development, which can be reflected by creatinine serum (Cr) level and resistive index (RI) value. This study aims to determine the correlation of total ischemic time to Cr levels reduction in one-month post-transplantation and RI value. Methods: This was a cross-sectional retrospective study involving subjects who underwent kidney transplantation in Sanglah General Hospital. In this study, the primary parameters were total ischemic time, Cr level, and RI value. The total ischemic time is calculated using a stopwatch intraoperatively. Cr level was obtained from blood examination, and RI value was obtained from the ultrasonography test. Data analysis was analyzed statistically using SPSS 24.0, and p < 0.05 was considered significant. Results: About 17 kidney transplant subjects were included in this study. The mean total ischemic time was 105 minutes and 43 seconds. There was an insignificant negative correlation between Cr level reduction and total ischemia time (r = -0.36; p = 0.89). An analysis of the correlation of total ischemic time and RI value, there was a linear correlation, but statistically insignificant (r = 0.11; p = 0.66). Conclusion: Total ischemic time has a negative correlation with post-transplant creatinine serum level and a positive correlation with the post-transplant resistive index value, but these results are not statistically significant.

Copyrights © 2020






Journal Info

Abbrev

nsmc

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

Description

Neurologico Spinale Medico Chirurgico (NSMC) is an open-access, single-blind peer-reviewed journal, published by Indonesian Neurospine Society (INSS) under the flag of Indonesian Neurosurgery Society (INS) and Faculty of Medicine, Udayana University. NSMC publishes articles which encompass all ...