Indonesia Chimica Acta
Volume 13, No 2: December 2020

A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells

Firdaus Firdaus (Hasanuddin University)
Nunuk Hariani Soekamto (Hasanuddin University)
Syadza Firdausiah (Hasanuddin University)
Musrifah Tahar (Hasanuddin University)

Article Info

Publish Date
14 Dec 2020


Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC50 value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.

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Journal Info





Chemical Engineering, Chemistry & Bioengineering


Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, ...