Jurnal Farmasains
Vol. 1 No. 2 (2011): Oktober 2010 - Maret 2011

AKTIVITAS SITOTOKSIK EKSTRAK ETANOLIK HERBA CIPLUKAN (Physalis angulata L.) PADA SEL KANKER LEHER RAHIM HeLa MELALUI MODULASI EKSPRESI PROTEIN p53

Andita Pra Darma (Unknown)
Rosana Anna Ashari (Unknown)
Perdana Adhi Nugroho (Unknown)
Ameilinda Monikawati (Unknown)
Ilham Agusta Fauzi (Unknown)
Adam Hermawan (Unknown)
Edy Meiyanto (Unknown)



Article Info

Publish Date
15 Dec 2012

Abstract

Cervical cancer is one of leading cause of cancer death in women in the developing countries. One of the strategy to prevent cervical cancer based on cytotoxic agents are now being developed. Ciplukan (Physalis angulata L.) is one of potential plant as chemopreventive agent due to Physalin and Withangulatin constituent in this plant. This study was aimed to know cytotoxic effect of ciplukan ethanolic extract (CEE) in human cervical carcinoma Hela cell line. Evaluation of cell viability value was determined using MTT assay. The expression of p53 as cell proliferation regulator was observed with immunocytochemistry assay. Ethanolic extract of ciplukan showed cytotoxic effect in HeLa cell line with IC50 of 158 µg/ml. Further observation of cell proliferation regulator showed that CEE induces expression of p53 that inhibit cell proliferation. The result showed that CEE has potential activity to be developed as anticancer agent in human cervical cancer.

Copyrights © 2011






Journal Info

Abbrev

farmasains

Publisher

Subject

Medicine & Pharmacology

Description

Farmasains is a scientific publication for widespread research and criticism topics in pharmacy science studies. Farmasains is published twice a year in April and November since June 2010 by Department of Pharmacy University of Muhammadiyah Malang. One volume of Farmasains is published in two year ...